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Infectious Disease: Gastroenteritis

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Total 621 results found since Jan 2013.

Diagnosing Pollen-food Allergy Syndrome Allergologically in a Patient with Suspected Eosinophilic Gastroenteritis
Intern Med. 2021 Jul 17. doi: 10.2169/internalmedicine.7664-21. Online ahead of print.ABSTRACTPollen-food allergy syndrome (PFAS) consists of type I allergy to pollen and multiple food items that are cross-reactive to the pollen. PFAS typically occurs in the oral cavity and can co-occur with eosinophilic esophagitis. However, it is infrequently reported to present with symptoms of eosinophilic gastroenteritis (EGE), such as abdominal pain and eosinophilic infiltration of the gastrointestinal tract. We herein report a patient with a condition initially suspected of being EGE based on symptoms and pathological findings that ...
Source: Internal Medicine - July 19, 2021 Category: Internal Medicine Authors: Hirotaka Kawauchi Yu Sato Nanase Honda Kazunori Furuhashi Kengo Murata Atsushi Hayashi Naoto Yokogawa Source Type: research

Possible therapeutic potential of a recombinant group 2 grass pollen allergen‐specific antibody fragment
We report the expression, purification, biochemical and immunological characterization of a monomeric single‐chain fragment (ScFv) of human origin specific for the major timothy grass pollen allergen, Phl p 2. The Phl p 2‐ScFv showed high affinity binding to the allergen and blocked the binding of allergic patients' polyclonal IgE to Phl p 2 up to 98%. Furthermore, it inhibited allergen‐induced basophil activation. The Phl p 2‐ScFv inhibited allergic patients' IgE binding to Phl p 2 as well as Phl p 2‐induced basophil activation and might be useful for passive immunotherapy of grass pollen allergy.
Source: Allergy - November 20, 2013 Category: Allergy & Immunology Authors: E. Gadermaier, S. Flicker, K. Blatt, P. Valent, R. Valenta Tags: Brief Communication Source Type: research

Allergen‐hybrids ‐ next generation vaccines for Fagales pollen immunotherapy
ConclusionThe hybrid molecules showed a more efficient uptake and processing by dendritic cells resulting in a modified T cell response. The proteins had a lower IgE‐binding capacity compared to the parental allergens, thus the high safety profile and increased efficacy emphasizes clinical application for the treatment of Fagales multi‐sensitization.This article is protected by copyright. All rights reserved.
Source: Clinical and Experimental Allergy - December 11, 2013 Category: Allergy & Immunology Authors: Ulrike Pichler, Michael Hauser, Heidi Hofer, Martin Himly, Elisabeth Hoflehner, Markus Steiner, Sonja Mutschlechner, Karin Hufnagl, Christof Ebner, Adriano Mari, Peter Briza, Barbara Bohle, Ursula Wiedermann, Fatima Ferreira, Michael Wallner Tags: Original Article‐Allergens Source Type: research

Do intestinal parasites enhance food allergy and atopic dermatitis?: A study in Warao Amerindian children
ConclusionGut inflammation caused by G. duodenalis may enhance food allergic reactivity contributing to the manifestation of AD in these children. However, other environmental factors (not considered in this work) as well as an atopic background among the Warao population would also contribute to the presence of AD.
Source: Pediatric Allergy and Immunology - January 13, 2014 Category: Allergy & Immunology Authors: Isabel Hagel, Franca Puccio, Elianska López, Dennis Lugo, Maira Cabrera, María C. Di Prisco Tags: Original Article Source Type: research

Hypoallergenic derivatives of Fel d 1 obtained by rational reassembly for allergy vaccination and tolerance induction
ConclusionsWe report the development of hypoallergenic reassembled Fel d 1 proteins suitable for vaccination and tolerance induction in cat allergic patients.This article is protected by copyright. All rights reserved.
Source: Clinical and Experimental Allergy - February 1, 2014 Category: Allergy & Immunology Authors: Mirela Curin, Milena Weber, Theresa Thalhamer, Ines Swoboda, Margit Focke, Katharina Blatt, Peter Valent, Katharina Marth, Tetiana Garmatiuk, Hans Grönlund, Josef Thalhamer, Susanne Spitzauer, Rudolf Valenta Tags: Original Article‐Allergens Source Type: research

Allergen hybrids – next generation vaccines for Fagales pollen immunotherapy
ConclusionThe hybrid molecules showed a more efficient uptake and processing by dendritic cells resulting in a modified T cell response. The proteins had a lower IgE‐binding capacity compared with the parental allergens, thus the high safety profile and increased efficacy emphasize clinical application for the treatment of Fagales multi‐sensitization.
Source: Clinical and Experimental Allergy - February 22, 2014 Category: Allergy & Immunology Authors: U. Pichler, M. Hauser, H. Hofer, M. Himly, E. Hoflehner, M. Steiner, S. Mutschlechner, K. Hufnagl, C. Ebner, A. Mari, P. Briza, B. Bohle, U. Wiedermann, F. Ferreira, M. Wallner Tags: Original Article Source Type: research

Eosinophilic gastroenteritis with refractory ulcer disease and gastrointestinal bleeding as a rare manifestation of seronegative gastrointestinal food allergy
Gastrointestinal bleeding and iron deficiency anaemia may cause severe symptoms and may require extensive diagnostics and substantial amounts of health resources.This case report focuses on the clinical presentation of a 22 year old patient with recurrent gastrointestinal bleeding from multilocular non-healing ulcers of the stomach, duodenum and jejunum over a period of four years. Extensive gastroenterological and allergological standard diagnostic procedures showed benign ulcerative lesions with tissue eosinophilia, but no conclusive diagnosis. Multiple diagnostic procedures were performed, until finally, endoscopically ...
Source: Nutrition Journal - September 17, 2014 Category: Nutrition Authors: Martin RaithelMarkus HahnKonrad DonhuijsenAlexander HagelAndreas NägelRalf RiekerMarkus NeurathMax Reinshagen Source Type: research

Development and evaluation of a sublingual tablet based on recombinant Bet v 1 in birch pollen‐allergic patients
ConclusionRecombinant Bet v 1 has been produced as a well‐characterized pharmaceutical‐grade biological drug. Sublingual administration of rBet v 1 tablets is safe and efficacious in patients with birch pollen allergic rhinoconjunctivitis.This article is protected by copyright. All rights reserved.
Source: Allergy - April 2, 2015 Category: Allergy & Immunology Authors: Emmanuel Nony, Julien Bouley, Maxime Le Mignon, Pierrick Lemoine, Karine Jain, Stéphane Horiot, Laurent Mascarell, Marc Pallardy, Renaud Vincentelli, Philippe Leone, Alain Roussel, Thierry Batard, Kathy Abiteboul, Bruno Robin, Olivier Beaumont, Monica Ar Tags: Original Article: Experimental Allergy and Immunology Source Type: research

Recombinant Fusion Allergens, Cry j 1 and Cry j 2 from Japanese Cedar Pollen, Conjugated with Polyethylene Glycol Potentiate the Attenuation of Cry j 1-Specific IgE Production in Cry j 1-Sensitized Mice and Japanese Cedar Pollen Allergen-Sensitized Monkeys
Conclusions: A high-dose injection of PEG-fusion appears to be a valid candidate for a safer and more effective vaccine than the conventional SIT extract for Japanese cedar pollinosis.Int Arch Allergy Immunol 2015;168:32-43
Source: International Archives of Allergy and Immunology - November 2, 2015 Category: Allergy & Immunology Source Type: research

Epitope-based vaccine for the treatment of der f 3 allergy.
EPITOPE-BASED VACCINE FOR THE TREATMENT OF DER F 3 ALLERGY. Nutr Hosp. 2015;32(n06):2763-2770 Authors: Zhan X, Li C, Jiang Y, Li N Abstract INTRODUCTION: mites allergic asthma is caused by exposure to home dust mite (HDM). Der f 3 is believed to be one of the major allergens in mites allergic asthma. The work was to identify the immune characteristics of Der f 3 epitope-based vaccine containing T cell and B cell epitopes. METHODS: T cell lines were generated from peripheral blood mononuclear cells of Der f 3 allergic patients. Three T cell epitopes and five B cell epitopes of Der f 3, which we id...
Source: Nutricion Hospitalaria - December 18, 2015 Category: Nutrition Authors: Zhan X, Li C, Jiang Y, Li N Tags: Nutr Hosp Source Type: research

Dust mite allergen Der f 4: Expression, characterization, and IgE‐binding in pediatric asthma
ConclusionsThis initial cloning and characterization of the Der f 4 allergen serves as a foundation for future studies into the clinical importance and application of this protein for house dust mite allergy.This article is protected by copyright. All rights reserved.
Source: Pediatric Allergy and Immunology - February 4, 2016 Category: Allergy & Immunology Authors: Yu‐bao Cui, Li‐li Yu, Fei‐xiang Teng, Nan Wang, Ying Zhou, Li Yang, Cheng‐bo Zhang Tags: Original Source Type: research