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Infectious Disease: Endemics

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We are grateful for the comment of Seidel et al and that the AAAAI Work Group Report “Use and interpretation of diagnostic vaccination in primary immunodeficiency” is of perceived value to our colleagues in Europe. We also appreciate their recent work regarding the use of tick-borne encephalitis (TBE) vaccine as a neoantigen in patients with primary immunodeficiency. TBE vaccination (TicoVac, Baxter, Berkshire, United Kingdom; FSME-IMMUN, Baxter, Vienna, Austria; or Encepur, Novartis, Basel, Switzerland) is of value in Europe as the disease is endemic in certain countries including China, Japan, and Russia. As the au...
Source: Journal of Allergy and Clinical Immunology - January 2, 2013 Category: Allergy & Immunology Authors: Jordan S. Orange, Rohit Katial Tags: Correspondence Source Type: research

Many Allergic to Fire Ant's Sting Don't Get Preventive Shots
Insect is endemic throughout the Southeast, researchers note, and can spur severe reaction Source: HealthDay Related MedlinePlus Pages: Allergy, Insect Bites and Stings
Source: MedlinePlus Health News - March 4, 2013 Category: Consumer Health News Source Type: news

Deworming is not a risk factor for the development of atopic diseases: a longitudinal study in Cuban schoolchildren
Conclusion & Clinical RelevanceOur results indicate that atopic diseases do not increase after anthelminthic treatment. Allergic sensitization on the other hand increases after deworming. As this increase appears only temporarily, deworming of schoolchildren does not seem to be a risk factor for the development of allergic sensitization, nor for atopic diseases.This article is protected by copyright. All rights reserved.
Source: Clinical and Experimental Allergy - April 13, 2013 Category: Allergy & Immunology Authors: Suzanne Desirée Werff, Jos W.R. Twisk, Meike Wördemann, Maiza Campos Ponce, Raquel Junco Díaz, Fidel Angel Núñez, Lázara Rojas Rivero, Mariano Bonet Gorbea, Katja Polman Tags: Original Article‐Epidemiology of Allergic Disease Source Type: research

Deworming is not a risk factor for the development of atopic diseases: a longitudinal study in Cuban school children
Conclusion & Clinical RelevanceOur results indicate that atopic diseases do not increase after anthelminthic treatment. Allergic sensitization on the other hand increases after deworming. As this increase appears only temporarily, deworming of schoolchildren does not seem to be a risk factor for the development of allergic sensitization, nor for atopic diseases.
Source: Clinical and Experimental Allergy - May 28, 2013 Category: Allergy & Immunology Authors: S. D. Werff, J. W. R. Twisk, M. Wördemann, M. Campos Ponce, R. Junco Díaz, F. A. Núñez, L. Rojas Rivero, M. Bonet Gorbea, K. Polman Tags: Original Article Source Type: research

Tick bite anaphylaxis: Incidence and management in an Australian emergency department
ConclusionWe report 34 cases of tick bite anaphylaxis over a 2 year period at a single hospital in a tick endemic area. The variation in the presenting symptoms and signs, as well as in management highlights the need for increased awareness for tick bite management in tick endemic areas.
Source: Emergency Medicine Australasia - July 21, 2013 Category: Emergency Medicine Authors: Tristan B Rappo, Alice M Cottee, Andrew M Ratchford, Brian J Burns Tags: Original Research Source Type: research

Penicillium marneffei infection and impaired IFN-γ immunity in humans with autosomal-dominant gain-of-phosphorylation STAT1 mutations
Penicillium marneffei is a pathogenic fungus endemic in Southeast Asia. P marneffei was an extremely rare pathogen in humans before the HIV epidemic, but following the exponential rise in the prevalence of HIV in Southeast Asia, penicilliosis emerged as a clinically significant opportunistic infection and is classified as an AIDS-defining illness. Less commonly, penicilliosis occurs in patients with other immunodeficiencies, such as severe combined immunodeficiency, common variable immunodeficiency, hyper-IgM syndrome, hyper-IgE syndrome, the presence of anti-IFN-γ autoantibody, diabetes mellitus, immunosuppressive therap...
Source: Journal of Allergy and Clinical Immunology - November 4, 2013 Category: Allergy & Immunology Authors: Pamela P.W. Lee, Huawei Mao, Wanling Yang, Koon-Wing Chan, Marco H.K. Ho, Tsz-Leung Lee, Jasper F.W. Chan, Patrick C.Y. Woo, Wenwei Tu, Yu-Lung Lau Tags: Letters to the Editor Source Type: research

Scientists identify potential vaccine candidate for pediatric malaria
(NIH/National Institute of Allergy and Infectious Diseases) Researchers have identified a substance, or antigen, that generates antibodies that can hinder the ability of malaria parasites to multiply, which may protect against severe malaria infection. The antigen, known as PfSEA-1, was associated with reduced parasite levels among children and adults in malaria-endemic areas.
Source: EurekAlert! - Infectious and Emerging Diseases - May 22, 2014 Category: Infectious Diseases Source Type: news

Fresh hope in hunt for malaria vaccine
Conclusion Using a combination of laboratory protein experiments, mouse infection studies, and human susceptibility cohorts, this research developed a new prototype vaccine targeting the PfSEA-1 protein. This approach shows promise in partially reducing malaria infection in mice. The vaccine appeared to mimic the natural resistance to malaria infection found in some children and adolescents living in malaria endemic regions of Tanzania and Kenya. It is important to note that the vaccine was not 100% effective but, if developed successfully, it may still be useful if used in combination with other vaccines. Though this l...
Source: NHS News Feed - May 23, 2014 Category: Consumer Health News Tags: Medication Pregnancy/child Source Type: news

What is the prototype of familial amyloid polyneuropathy?
Familial amyloid polyneuropathy (FAP) is a hereditary form of amyloidosis most commonly caused by mutations in transthyretin (TTR) and was initially reported from endemic foci in Portugal, Japan and Sweden. However, development in gene diagnostic techniques revealed that FAP patients are more widely distributed and have varied phenotypes even in the same mutation.1 2 For example, Japanese patients who have early onset FAP with amyloidogenic TTR Val30Met mutation (FAP amyloidogenic transthyretin (ATTR) Val30Met) in endemic foci in Kumamoto and Nagano prefectures exhibit clinicopathological features distinct from those of la...
Source: Journal of Neurology, Neurosurgery and Psychiatry - June 10, 2014 Category: Neurosurgery Authors: Koike, H., Sobue, G. Tags: Genetics, Immunology (including allergy), Neuromuscular disease, Peripheral nerve disease Editorial commentaries Source Type: research

Changes in pathological and biochemical findings of systemic tissue sites in familial amyloid polyneuropathy more than 10 years after liver transplantation
Conclusions FAP may shift to systemic WT TTR amyloid formation after LT, which seems to be similar to the process in SSA. The truncation of TTR in amyloid deposits may depend on some genetic or environmental factors other than undergoing LT.
Source: Journal of Neurology, Neurosurgery and Psychiatry - June 10, 2014 Category: Neurosurgery Authors: Oshima, T., Kawahara, S., Ueda, M., Kawakami, Y., Tanaka, R., Okazaki, T., Misumi, Y., Obayashi, K., Yamashita, T., Ohya, Y., Ihse, E., Shinriki, S., Tasaki, M., Jono, H., Asonuma, K., Inomata, Y., Westermark, P., Ando, Y. Tags: Genetics, Immunology (including allergy), Neuromuscular disease, Peripheral nerve disease Source Type: research

Vaccine made from complex of two malaria proteins protects mice from lethal infection
(NIH/National Institute of Allergy and Infectious Diseases) An experimental vaccine designed to spur production of antibodies against a key malaria parasite protein, AMA1, was developed more than decade ago by scientists from NIAID, part of NIH. It showed promise in test-tube and animal experiments and in early-stage clinical trials, but returned disappointing results in recent human trials conducted in malaria-endemic countries.
Source: EurekAlert! - Infectious and Emerging Diseases - June 23, 2014 Category: Infectious Diseases Source Type: news

Opisthorchis felineus liver fluke invasion is an environmental factor modifying genetic risk of atopic bronchial asthma.
Abstract According to epidemiological observations, Opisthorchis felineus liver fluke invasion is negatively associated with the development and severity of allergic diseases in endemic regions of Russia. We hypothesized that the invasion is an important factor in gene-environmental interactions (GEI) underlying allergy. To prove this, we tested 10 single nucleotide polymorphisms of immune response modifying genes in 428 individuals stratified by atopic bronchial asthma presence and O. felineus invasion. Using regression models, a statistically significant interaction between the rs6737848 polymorphism of SOCS5 ge...
Source: Acta Tropica - July 10, 2014 Category: Infectious Diseases Authors: Saltykova IV, Ogorodova LM, Bragina EY, Puzyrev VP, Freidin MB Tags: Acta Trop Source Type: research

Correlation Between Helicobacter pylori Infection, IgE Hypersensitivity, and Allergic Disease in Korean Adults
ConclusionsThe statuses of H. pylori infection, IgE hypersensitivity, and allergic diseases differ with age group, there being a higher prevalence of IgE‐related allergic disease and a lower H. pylori infection rate among young adults. The hygiene hypothesis might explain these findings in young Koreans, due to the rapid development and improvements in sanitation in Korea.
Source: Helicobacter - September 25, 2014 Category: Gastroenterology Authors: Sang Pyo Lee, Sun‐Young Lee, Jeong Hwan Kim, In‐Kyung Sung, Hyung Seok Park, Chan Sup Shim, Hee‐Won Moon Tags: Original Article Source Type: research

Tick bite‐related meat allergy as a cause of chronic urticaria, angioedema, and anaphylaxis in endemic areas
Source: International Journal of Dermatology - November 27, 2014 Category: Dermatology Authors: Grant K. Ghahramani, James Temprano Tags: Correspondence Source Type: research

Update on the safety profile of certolizumab pegol in rheumatoid arthritis: an integrated analysis from clinical trials
Conclusions No new or unexpected safety signals associated with CZP emerged in this updated long-term safety analysis. While SIE rates were higher for CZP than for placebo in RCT, the rate decreased with continued exposure to CZP. These rates are consistent with data previously reported for CZP and other tumour necrosis factor inhibitors.
Source: Annals of the Rheumatic Diseases - December 4, 2014 Category: Rheumatology Authors: Bykerk, V. P., Cush, J., Winthrop, K., Calabrese, L., Lortholary, O., de Longueville, M., van Vollenhoven, R., Mariette, X. Tags: Open access, Immunology (including allergy), Connective tissue disease, Degenerative joint disease, Musculoskeletal syndromes, Rheumatoid arthritis, Epidemiology Clinical and epidemiological research Source Type: research