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Clinical utility of the updated European Organization for Research and Treatment of Cancer/Invasive Fungal Infections Cooperative Group and the National Institute of Allergy and the Mycoses Study Group Education and Research Consortium computed tomography criteria of invasive pulmonary aspergillosis in hematological malignancies
Hematology. 2021 Dec;26(1):398-407. doi: 10.1080/16078454.2021.1931739.ABSTRACTInvasive pulmonary aspergillosis is a life-threatening complication in the cases of patients with hematologic malignancies. In December 2019, the European Organization for Research and Treatment of Cancer/Invasive Fungal Infections Cooperative Group and the National Institute of Allergy and the Mycoses Study Group Education and Research Consortium published a revision and an update of the consensus definitions of invasive fungal disease. The aim of this study was to evaluate the signs and radiologic patterns of early-stage invasive pulmonary asp...
Source: Hematology - May 31, 2021 Category: Hematology Authors: Marta Ha łaburda-Rola Tomasz Dzieci ątkowski Micha ł Górka Olgierd Rowi ński Laretta Grabowska-Derlatka Source Type: research

Incidence and Outcome of Invasive Fungal Diseases in Children With Hematological Malignancies and/or Allogeneic Hematopoietic Stem Cell Transplantation: Results of a Prospective Multicenter Study
Conclusion: This prospective multicenter study provides information on the current incidence and outcome of IFD in the real life setting. Practice variation between the centers may help to ultimately improve antifungal management in children at highest risk for IFDs. Introduction Available data on the incidence and outcome of invasive fungal diseases (IFD) in children treated for a hematological malignancy or undergoing allogeneic hematopoietic stem cell transplantation (HSCT) are mostly based on single site, retrospective studies or on studies performed prior to the availability of newer compounds such as broad-sp...
Source: Frontiers in Microbiology - April 15, 2019 Category: Microbiology Source Type: research

Allergic bronchopulmonary aspergillosis as an occupational disease - special risk in waste management
Discussion: ABPA as an occupational disease and a particular risk in waste management have not yet been described. In both cases, the misdiagnosis of drug-resistant pneumonia was initially made. The necessary change of workplace was thus delayed. Exposure to moulds, however, was not entirely avoidable at either of the new workplaces. Infiltrates and type I typical airway obstruction developed again. ABPA is a work-related serious illness which requires a strict avoidance of allergen exposition and thus a change of workplace or even occupation.
Source: European Respiratory Journal - December 6, 2017 Category: Respiratory Medicine Authors: Preisser, A. M., Harth, V. Tags: Occupational and Environmental Health Source Type: research

Lung haemangioma presenting with air-crescent-sign like image in an extreme premature baby
A preterm girl was delivered at 26 weeks by caesarean section because of suspected chorioamnionitis. The pregnancy had been complicated by prolonged rupture of the membranes since 19 weeks. She had a complicated respiratory course with need for invasive ventilation, recurrent pneumonia and two episodes of left-sided pneumothorax, with evolution to bronchopulmonary disease. As a right lower lobe mass was suspected (figure 1), a high-resolution CT chest scan was done which revealed a round homogeneous consolidation with an air crescent sign, typically seen in pulmonary aspergillosis (figure 2). Although there were no clinica...
Source: Archives of Disease in Childhood - Fetal and Neonatal Edition - April 19, 2017 Category: Perinatology & Neonatology Authors: de Laat, M., Proesmans, M., Breysem, L., Debeer, A. Tags: Oncology, Journalology, Immunology (including allergy), Drugs: infectious diseases, Pneumonia (infectious disease), TB and other respiratory infections, Pregnancy, Reproductive medicine, Child health, Infant health, Neonatal health, Radiology, Pneumonia ( Source Type: research

Allergic bronchopulmonary aspergillosis complicating COPD is associated with a higher exacerbation rate and a distinct pattern on chest CT scan compared to COPD
Recent data support that patients with COPD can experienced associated asthma in an overlap syndrome. This raise hypothesis of specific complications in these patients as allergic broncho-pulmonary aspergillosis (ABPA), usually seen in asthma patients, exhibiting potential specific features when associated to COPD. We compiled 16 cases of ABPA (Patterson criteria) diagnosed in COPD patients (GOLD criteria,Tabaco > 10 PY) in a monocentrique retrospective study, then compared to 16 COPD matched patients on age and FEV1, with similar overall follow up (7.8 years). ABPA-COPD group age was 61.1 years, FEV1 was 36% (1127mL), ...
Source: European Respiratory Journal - November 7, 2016 Category: Respiratory Medicine Authors: Maignant, A., Mellot, F., Haudebourg, L., Neveu, H., Rivaud, E., Catherinot, E., Bron, C., Salvator, H., Chabrol, A., Anitei, O., Trebbia, G., Devaquet, J., Cerf, C., Couderc, L.-J., Tcherakian, C. Tags: 5.3 Allergy and Immunology Source Type: research

The relationship between biomarkers of fungal allergy and lung damage in asthma
ConclusionsIgE sensitisation to thermotolerant filamentous fungi, in particular A. fumigatus but not total IgE, is associated with fixed airflow obstruction and a number of radiological abnormalities in moderate to severe asthma. All patients with IgE sensitisation to A. fumigatus are at risk of lung damage irrespective of whether they meet the criteria for ABPA.This article is protected by copyright. All rights reserved.
Source: Clinical and Experimental Allergy - October 31, 2016 Category: Allergy & Immunology Authors: Kerry F. Woolnough, Matthew Richardson, Christopher Newby, Michelle Craner, Michelle Bourne, William Monteiro, Salman Siddiqui, Peter Bradding, Catherine H. Pashley, Andrew J. Wardlaw Tags: Original Article ‐Asthma and Rhinitis Source Type: research

18F-labeled Calcofluor Derivatives for PET Imaging and Diagnosis of Aspergillus Infection
Aspergillus is a common fungal lung infection with high mortality rates in immune compromised patients. The inability to diagnose this infection impedes treatment. Blood based diagnostic tests for this infection lack sensitivity and specificity due to cross reactivity. Other methods of diagnosis are invasive and labor intensive. The ability to accurately and non-invasively diagnose infection in Aspergillus immune compromised populations may greatly improve treatment and lower mortality rates. This technology uses 18F-labeled calcofluor derivatives for positron emission tomography (PET) imaging of filamentous fungal infecti...
Source: NIH OTT Licensing Opportunities - July 9, 2014 Category: Research Authors: admin Source Type: research

Small Molecule Imaging of Fungi by Positron Emission Tomography Scanning
This technology relates to the field of radioactive, isotopically-labeled calcofluor derivatives and uses of such compounds to detect a broad spectrum of filamentous fungi including pathogenic species such asAspergillus andMucorales, by diagnostic imaging methods such as positron emission tomography (PET) scanning.Aspergillosis and other filamentous fungal infections are increasingly common fungal lung infection with high mortality rates (over 50%) in immune compromised patients, such as those receiving chemotherapy, stem cell/organ transplantation, or HIV patients. One-year survival of the infected patients ranges from 59...
Source: NIH OTT Licensing Opportunities - July 9, 2014 Category: Research Authors: ajoyprabhu3 Source Type: research