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Healthcare costs associated with allergic rhinitis, asthma allergy immunotherapy.
This study estimated healthcare costs and utilisation for patients with AR and asthma. Mean annual outpatient visits, pharmaceutical costs and inpatient hospitalisations were calculated for 2010 and 2014, with pharmaceutical and inpatient costs stratified by AIT use. AR and asthma patients had a 35% higher mean number of physician visits and up to 90% higher mean pharmaceutical costs compared to controls. The cost of pharmaceuticals and inpatient hospitalisations were 54% lower in those prescribed AIT. Further research is recommended to understand the reasons for these cost differences. PMID: 31818082 [PubMed - as supplied by publisher]
Source: European Annals of Allergy and Clinical Immunology - December 12, 2019 Category: Allergy & Immunology Tags: Eur Ann Allergy Clin Immunol Source Type: research

The role of epigenetics in allergy and asthma development
Purpose of review Epigenetic mechanisms are known to play a crucial role in the pathogenesis of asthma, allergic rhinitis, atopic dermatitis, food allergy, and other allergic disorders, especially through mediating the effects of the environmental factors, well recognized allergy-risk modifiers. The aim of this work was to provide a concise but comprehensive review of the recent progress in the epigenetics of allergic diseases. Recent findings Recent few years have substantially expanded our knowledge on the role of epigenetics in the pathogenesis and clinical picture of allergies. Specifically, it has been shown that...
Source: Current Opinion in Allergy and Clinical Immunology - January 3, 2020 Category: Allergy & Immunology Tags: MECHANISMS OF ALLERGY AND ADULT ASTHMA: Edited by J. Andrew Grant and Enrico Heffler Source Type: research

Engaging Patient Partners In State of the Art Allergy Care: Finding Balance When Discussing Risk.
CONCLUSION: Communicating risk is complex and validated patient decision aids using visual aids, presenting essential information, using knowledge checks, and incorporating values clarification can reduce decisional conflict and improve decisional self-efficacy. PMID: 32044453 [PubMed - as supplied by publisher]
Source: Annals of Allergy, Asthma and Immunology - February 6, 2020 Category: Allergy & Immunology Authors: Shaker M, Hsu-Blatman K, M Abrams E Tags: Ann Allergy Asthma Immunol Source Type: research

Reimbursement Patterns and User Experiences in Pediatric Allergy Home Telehealth.
CONCLUSION: Patients showed reservations about HTH initially but were very satisfied with their experience. Both private and public payers reimbursed HTH the same as in-person appointments. HTH is both well accepted by patients and financially viable. PMID: 32526378 [PubMed - as supplied by publisher]
Source: Annals of Allergy, Asthma and Immunology - June 7, 2020 Category: Allergy & Immunology Authors: Mehta P, Braskett M, Tam JS, Espinoza J Tags: Ann Allergy Asthma Immunol Source Type: research

Factors Contributing to Underuse of Epinephrine Autoinjectors in Pediatric Patients with Food Allergy.
CONCLUSION: Multiple factors contribute to underuse of EA for the treatment of severe allergic reactions. Results from this study highlight the need for continuous EA education in caregivers of and pediatric patients with food allergies, using a mutlipronged approach targeting clear symptom recognition and alleviation of fear of EA use. PMID: 32950683 [PubMed - as supplied by publisher]
Source: Annals of Allergy, Asthma and Immunology - September 16, 2020 Category: Allergy & Immunology Authors: Glassberg B, Nowak-Wegrzyn A, Wang J Tags: Ann Allergy Asthma Immunol Source Type: research

Food Allergy-Related Bullying and Associated Peer Dynamics Among Black and White Children in FORWARD Study.
CONCLUSION: Bullying due to FA is common and caregivers, medical professionals and school administrators can help reduce bullying by screening for bullying and supporting and educating school policies. PMID: 33157272 [PubMed - as supplied by publisher]
Source: Annals of Allergy, Asthma and Immunology - November 3, 2020 Category: Allergy & Immunology Authors: Brown D, Negris O, Gupta R, Herbert L, Lombard L, Bozen A, Assa'ad A, Chura A, Andy-Nweye AB, Fox S, Mahdavinia M, Tobin M, Robinson A, Sharma H, Coleman A, Jiang J, Bilaver L, Fierstein JL, Galic I, Newmark P, Pongracic JA, Pappalardo AA, Warren C Tags: Ann Allergy Asthma Immunol Source Type: research

Advances in mechanisms of allergy and clinical immunology in 2012
Manuscripts published in the “Mechanisms of allergy and clinical immunology” section of the Journal of Allergy and Clinical Immunology during 2012 enhanced our knowledge of the involvement of cytokines and other mediators in allergic disorders and described novel approaches for understanding mechanisms of allergic and immunologic diseases. Also published were articles focused on mechanisms of allergen-specific immunotherapy and the development of novel antiallergic treatments, as well as strategies to achieve tolerance to allergens. The highlights of these studies and their potential clinical implications are summarized in this review.
Source: Journal of Allergy and Clinical Immunology - January 25, 2013 Category: Allergy & Immunology Authors: Bruce S. Bochner, Marc E. Rothenberg, Joshua A. Boyce, Fred Finkelman Tags: Advances in allergy, asthma, and immunology series 2013 Source Type: research

Cor a 1–reactive T cells and IgE are predominantly cross-reactive to Bet v 1 in patients with birch pollen–associated food allergy to hazelnut
Conclusion: Analysis of primary allergen-specific T cells combined with flow cytometry–based proliferation assays facilitates investigation of allergen-specific T-cell subpopulations in subjects and might be helpful to evaluate the effect of birch-specific immunotherapy on pollen-associated food allergies.
Source: Journal of Allergy and Clinical Immunology - December 13, 2012 Category: Allergy & Immunology Authors: Claudia Hofmann, Stephan Scheurer, Kathrin Rost, Edith Graulich, Annette Jamin, Kay Foetisch, Joachim Saloga, Stefan Vieths, Kerstin Steinbrink, Henric S. Adler Tags: Mechanisms of allergy and clinical immunology Source Type: research

Food allergy: the perspectives of prevention using vitamin D
Purpose of reviewWe reviewed the scientific publications in the last 2 years on the connections between vitamin D and food allergy, and endeavor to focus on the possible indications for supplementation in order to prevent allergies. Recent findingsEcological studies have suggested a possible relationship between sun exposure and atopic diseases such as asthma, atopic dermatitis and anaphylaxis. However, no direct evaluation of vitamin D status has been performed. Recent studies evaluating the relationship with vitamin D levels at birth or during pregnancy have shown conflicting results with the lower levels of vitamin D as...
Source: Current Opinion in Allergy and Clinical Immunology - July 17, 2012 Category: Allergy & Immunology Tags: FOOD ALLERGY: Edited by Alessandro Fiocchi and Julie Wang Source Type: research

Baked Egg Food Challenges – Clinical Utility of Skin Test to Baked Egg and Ovomucoid in Children with Egg Allergy
Conclusions and clinical relevanceA SPT of <2mm to muffin had a high negative predictive value to baked egg challenge. Ovomucoid SPT ≥ 11 mm was very likely to predict a reaction to baked egg.. In these children, deferring the challenge would be appropriate.This article is protected by copyright. All rights reserved.
Source: Clinical and Experimental Allergy - June 5, 2013 Category: Allergy & Immunology Authors: John Wei‐Liang TAN, Dianne E Campbell, Paul J. Turner, Alyson Kakakios, Melanie Wong, Sam Mehr, Preeti Joshi Tags: Original Article‐Clinical Allergy Source Type: research

Population response to change in infant feeding guidelines for allergy prevention
Conclusion: Updated national allergy guidelines are associated with reduced delay in introduction of solids, egg, and peanut and an increase in partially hydrolyzed formula use among formula-fed infants. Higher socioeconomic status and absence of family history of allergies were associated with better uptake of feeding guidelines.
Source: Journal of Allergy and Clinical Immunology - January 6, 2014 Category: Allergy & Immunology Authors: Dean Tey, Katrina J. Allen, Rachel L. Peters, Jennifer J. Koplin, Mimi L.K. Tang, Lyle C. Gurrin, Anne-Louise Ponsonby, Adrian J. Lowe, Melissa Wake, Shyamali C. Dharmage, HealthNuts study investigators Tags: Food, drug, insect sting allergy, and anaphylaxis Source Type: research

Predictive value of allergy tests for neuromuscular blocking agents: tackling an unmet need
ConclusionSkin test and BAT have an excellent negative predictive value in our series. The uneventful re‐exposure of rocuronium in patients with an isolated positive sIgE result to rocuronium calls into question the predictive value of this assay and suggests sIgE serology to be less clinically predictive than the functional investigations relying upon activation of mast cells or basophils. The presence of a positive sIgE to substituted ammonium structures such as morphine does not preclude further use of benzylisoquinolines.This article is protected by copyright. All rights reserved.
Source: Clinical and Experimental Allergy - May 21, 2014 Category: Allergy & Immunology Authors: J Leysen, A Uyttebroek, V Sabato, CH Bridts, LS Clerck, DG Ebo Tags: Original Article‐Clinical Allergy Source Type: research

People Don't Usually Complete Allergy Shots or DropsPeople Don't Usually Complete Allergy Shots or Drops
Doctors may recommend allergy shots or sublingual therapies, but most patients don't start the treatments, reports a new study. Reuters Health Information
Source: Medscape Allergy Headlines - June 6, 2014 Category: Allergy & Immunology Tags: Allergy & Clinical Immunology News Source Type: news

Casein‐Specific Il‐4 And Il‐13 Secreting T Cells: A Tool To Implement Diagnosis Of Cow's Milk Allergy
ConclusionsEnumeration of casein‐specific IL‐4 and IL‐13 secreting T cells appears a promising tool to improve diagnosis and, if confirmed in larger studies, could permit less frequent use of the oral food challenge.This article is protected by copyright. All rights reserved.
Source: Allergy - July 10, 2014 Category: Allergy & Immunology Authors: Bénédicte Michaud, Joseph Aroulandom, Naour Baiz, Flore Amat, Rahelé Gouvis‐Echraghi, Sophie Candon, Anne‐Perrine Foray, Rémy Couderc, Jean‐François Bach, Lucienne Chatenoud, Jocelyne Just Tags: Original Article: Experimental Allergy and Immunology Source Type: research

Trimethoprim-sulfamethoxazole-induced aseptic meningitis-not just another sulfa allergy.
CONCLUSION: TMP-SMX is the most common antibiotic to cause drug-induced aseptic meningitis. By being aware of this reaction, allergists are well poised to diagnose TSIAM and prevent future reoccurrences for the patient. PMID: 25240332 [PubMed - as supplied by publisher]
Source: Annals of Allergy, Asthma and Immunology - September 17, 2014 Category: Allergy & Immunology Authors: Bruner KE, Coop CA, White KM Tags: Ann Allergy Asthma Immunol Source Type: research