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Anti-IL-4 as a new strategy in allergy.
Authors: Schmidt-Weber CB Abstract Allergic diseases are characterized by an overreaction characterized by Th2-type cell response, and as a consequence, an IgE-switched B cell immunity. Obviously, type-2 cytokines (IL-4, IL-5, IL-9, IL-13) and particularly IL-4 have been identified as potential targets for allergy treatment. While initial experiences using anti-IL-4 principles in asthma were rather ambiguous, more recent studies using an IL-4 mute in blocking the IL-4 and IL-13 receptor have shown promising results. Furthermore, our understanding of IL-4 biology is more specific and may promote more targeted interv...
Source: Chemical Immunology and Allergy - December 2, 2014 Category: Allergy & Immunology Tags: Chem Immunol Allergy Source Type: research

Attitudes toward allergy: what do the pediatricians think?
CONCLUSION: Increased appropriate referrals and improved patient outcomes could result from efforts to enhance A/I education during medical school and residency, maintain effective communication with referring physicians, and break down referral barriers to improve physicians' attitudes toward A/I. PMID: 25442696 [PubMed - in process]
Source: Annals of Allergy, Asthma and Immunology - November 1, 2014 Category: Allergy & Immunology Authors: Convers KD, Slavin RG Tags: Ann Allergy Asthma Immunol Source Type: research

IgE recognition patterns in peanut allergy are age dependent: perspectives of the EuroPrevall study
ConclusionSensitization to Ara h 1, 2 and 3 is usually acquired in childhood. IgE to Ara h 2 ≥1.0 kUA/L is significantly associated with the development of systemic reactions to peanut.This article is protected by copyright. All rights reserved.
Source: Allergy - January 24, 2015 Category: Allergy & Immunology Authors: Barbara K. Ballmer‐Weber, Jonas Lidholm, Montserrat Fernández‐Rivas, Suranjith Seneviratne, Kay‐Martin Hanschmann, Lothar Vogel, Peter Bures, Philipp Fritsche, Colin Summers, André C. Knulst, Thuy‐My Le, Isabel Reig, Nikolaos G. Papadopoulos, At Tags: Original Article: Experimental Allergy and Immunology Source Type: research

Comprehensive Metabolomics Identifies the Alarmin Uric Acid as a Critical Signal for the Induction of Peanut Allergy
ConclusionOverproduction of the UA alarmin in the local microenvironment plays a critical role in the induction of peanut allergic sensitization, likely due to its ability to activate DCs. These finding suggest that cellular damage or tissue injury may be an essential requisite for the development of allergic sensitization to foods.This article is protected by copyright. All rights reserved.
Source: Allergy - February 3, 2015 Category: Allergy & Immunology Authors: Joshua Kong, Kenneth Chalcraft, Talveer S. Mandur, Rodrigo Jimenez‐Saiz, Tina D. Walker, Susanna Goncharova, Melissa E. Gordon, Leen Naji, Kristin Flader, Mark Larché, Derek K. Chu, Susan Waserman, Brian McCarry, Manel Jordana Tags: Original Article: Experimental Allergy and Immunology Source Type: research

Association of Single Nucleotide Polymorphisms in the MD-2 Gene Promoter Region With Der p 2 Allergy.
CONCLUSIONS: Our results indicated that 2 SNPs in the MD-2 promoter region were significantly associated with Der p 2-specific Ig E, and thereby suggest that these SNPs may play a major role in susceptibility to Der p 2-triggered immune responses in a Taiwanese population. PMID: 25749780 [PubMed - as supplied by publisher]
Source: Allergy, Asthma and Immunology Research - March 12, 2015 Category: Allergy & Immunology Tags: Allergy Asthma Immunol Res Source Type: research

Self-reported penicillin allergy may be undiagnosed chronic urticaria
HOUSTON – The higher prevalence of chronic urticaria in patients with self-reported penicillin allergy suggests that these patients may be confusing one condition with the other, according to a late-breaking study presented at the annual meeting of the American Academy of Allergy, Asthma, and...
Source: Skin and Allergy News - March 19, 2015 Category: Dermatology Tags: FPN News FPN Allergy & Immunology FPN Dermatology HOSP News IMN News IMN Allergy IMN Dermatology Source Type: news

Factors associated with negative histamine control for penicillin allergy skin testing in the inpatient setting.
CONCLUSION: Regression analysis supports ICU stay during skin testing as associated with a high OR for a negative histamine response independent of age. Systemic corticosteroids, H2 blockers, and older age are associated with a significant OR for a negative histamine response. This is one of largest studies on factors associated with a negative histamine response for the inpatient setting and has significant implications for clinical practice. PMID: 25959032 [PubMed - as supplied by publisher]
Source: Annals of Allergy, Asthma and Immunology - May 7, 2015 Category: Allergy & Immunology Authors: Geng B, Thakor A, Clayton E, Finkas L, Riedl MA Tags: Ann Allergy Asthma Immunol Source Type: research

Ultra short pre-seasonal subcutaneous immunotherapy and pre-coseasonal sublingual immunotherapy for pollen allergy: an evaluation of patient's preference in real life.
CONCLUSION: Patients are active subjects in decisional process. Trying to apply in real life the indications coming from guidelines about patient's preference is an important matter. In our patients SCIT with ultra short schedule and SLIT are similarly preferred. PMID: 24067339 [PubMed - indexed for MEDLINE]
Source: European Annals of Allergy and Clinical Immunology - August 2, 2015 Category: Allergy & Immunology Tags: Eur Ann Allergy Clin Immunol Source Type: research

Prevalence and Clinical Impact of IgE-Mediated Food Allergy in School Children With Asthma: A Double-Blind Placebo-Controlled Food Challenge Study.
CONCLUSIONS: Although food-induced respiratory reactions in children with asthma were rare, they were classified as severe and associated with worse morbidity, greater severity, and poorer control. As the most commonly observed symptoms were coughing and rhinitis, which can be easily misdiagnosed, a proper diagnosis is essential for improving the management of both clinical conditions. PMID: 26333701 [PubMed]
Source: Allergy, Asthma and Immunology Research - September 6, 2015 Category: Allergy & Immunology Tags: Allergy Asthma Immunol Res Source Type: research

Occupational Allergy to Peach (Prunus persica) Tree Pollen and Potential Cross-Reactivity between Rosaceae Family Pollens.
Abstract Orchard workers in north China are highly exposed to orchard pollens, especially peach and other Rosaceae family pollens during pollination season. The aim of this study was to investigate whether occupational allergy to peach tree pollen as a member of Rosaceae family is IgE-mediated and to evaluate the cross-reactivity among Rosaceae family pollens. Allergen skin test and conjunctival challenge test were performed; enzyme linked immune-sorbent assay (ELISA), inhibiting ELISA, western immunoblotting and inhibiting western immunoblotting were done with Rosaceae family orchard pollens, including peach, apr...
Source: Iranian Journal of Allergy, Asthma and Immunology - October 1, 2015 Category: Allergy & Immunology Authors: Jiang N, Yin J, Mak P, Wen L Tags: Iran J Allergy Asthma Immunol Source Type: research

Characteristics of Anaphylaxis in 907 Chinese Patients Referred to a Tertiary Allergy Center: A Retrospective Study of 1,952 Episodes.
CONCLUSIONS: The present study showed that anaphylaxis appeared to occur more often in adults than in infants and children, which were in contrast to those found in other countries. In particular, wheat allergens played a prominent role in triggering food-induced anaphylaxis, followed by fruits/vegetables. Traditional Chinese medicine was a cause of drug-induced anaphylaxis. Furthermore, exercise was the most common factor aggravating anaphylaxis. Education regarding the more aggressive use of epinephrine in the emergency setting is clearly needed. PMID: 27126729 [PubMed]
Source: Allergy, Asthma and Immunology Research - April 30, 2016 Category: Allergy & Immunology Tags: Allergy Asthma Immunol Res Source Type: research

Oral Food Desensitization in Children With IgE-Mediated Cow's Milk Allergy: Immunological Changes Underlying Desensitization.
CONCLUSIONS: The OIT protocol was safe and effective in inducing milk desensitization in 70% of the children with CMA, leading to alterations in their immune profiles toward a nonallergic phenotype. PMID: 27826960 [PubMed - in process]
Source: Allergy, Asthma and Immunology Research - November 10, 2016 Category: Allergy & Immunology Tags: Allergy Asthma Immunol Res Source Type: research

Accurate Determination of Childhood Food Allergy Prevalence and Correction of Unnecessary Avoidance.
CONCLUSIONS: It is possible that a considerable number of children unnecessarily eliminate food because of suspected FA. PMID: 28497919 [PubMed]
Source: Allergy, Asthma and Immunology Research - May 13, 2017 Category: Allergy & Immunology Tags: Allergy Asthma Immunol Res Source Type: research

Age-Based Causes and Clinical Characteristics of Immediate-Type Food Allergy in Korean Children.
CONCLUSIONS: The 5 major causative foods of immediate-type FA in Korean children were cow's milk, hen's eggs, wheat, walnuts, and peanuts. The distribution of causative foods was considerably distinctive according to different age groups. Anaphylaxis was reported in 30.5% of immediate-type FA cases. PMID: 28677356 [PubMed]
Source: Allergy, Asthma and Immunology Research - July 6, 2017 Category: Allergy & Immunology Tags: Allergy Asthma Immunol Res Source Type: research

Prevalence of Immediate-Type Food Allergy in Korean Schoolchildren in 2015: A Nationwide, Population-based Study.
CONCLUSIONS: The prevalence of current immediate-type FA and food-induced anaphylaxis in Korean schoolchildren in 2015 was 4.06% and 0.97%, respectively. Peanuts, cow's milk, hen's egg, fruits, crustaceans, and tree nuts are common allergens. PMID: 28677354 [PubMed]
Source: Allergy, Asthma and Immunology Research - July 6, 2017 Category: Allergy & Immunology Tags: Allergy Asthma Immunol Res Source Type: research