Comprehensive Metabolomics Identifies the Alarmin Uric Acid as a Critical Signal for the Induction of Peanut Allergy

ConclusionOverproduction of the UA alarmin in the local microenvironment plays a critical role in the induction of peanut allergic sensitization, likely due to its ability to activate DCs. These finding suggest that cellular damage or tissue injury may be an essential requisite for the development of allergic sensitization to foods.This article is protected by copyright. All rights reserved.

Source: Allergy - February 3, 2015 Category: Allergy & Immunology Authors: Joshua Kong, Kenneth Chalcraft, Talveer S. Mandur, Rodrigo Jimenez‐Saiz, Tina D. Walker, Susanna Goncharova, Melissa E. Gordon, Leen Naji, Kristin Flader, Mark Larché, Derek K. Chu, Susan Waserman, Brian McCarry, Manel Jordana Tags: Original Article: Experimental Allergy and Immunology Source Type: research