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Total 17 results found since Jan 2013.
Viral escape from NK cell-mediated immunosurveillance: A lesson for cancer immunotherapy?
This article is protected by copyright. All rights reserved.PMID:37526136 | DOI:10.1002/eji.202350465
Source: European Journal of Immunology - August 1, 2023 Category: Allergy & Immunology Authors: Pouria Momayyezi Eleni Bilev Hans-Gustaf Ljunggren Quirin Hammer Source Type: research
The thioredoxin system: balancing redox responses in immune cells and tumors
This article is protected by copyright. All rights reserved.PMID:36285367 | DOI:10.1002/eji.202249948
Source: European Journal of Immunology - October 26, 2022 Category: Allergy & Immunology Authors: Jonathan Muri Manfred Kopf Source Type: research
Design of Personalized Neoantigen RNA Vaccines Against Cancer Based on Next-Generation Sequencing Data
Methods Mol Biol. 2022;2547:165-185. doi: 10.1007/978-1-0716-2573-6_7.ABSTRACTThe good clinical results of immune checkpoint inhibitors (ICIs) in recent cancer therapy and the success of RNA vaccines against SARS-nCoV2 have provided important lessons to the scientific community. On the one hand, the efficacy of ICI depends on the number and immunogenicity of tumor neoantigens (TNAs) which unfortunately are not abundantly expressed in many cancer subtypes. On the other hand, novel RNA vaccines have significantly improved both the stability and immunogenicity of mRNA and its efficient delivery, this way overcoming past techn...
Source: Mol Biol Cell - September 6, 2022 Category: Molecular Biology Authors: Bego ña Alburquerque-González Mar ía Dolores López-Abellán Gin és Luengo-Gil Silvia Montoro-Garc ía Pablo Conesa-Zamora Source Type: research
Anti-Cancer Virotherapy in Russia: Lessons from the Past, Current Challenges and Prospects for the Future
Curr Pharm Biotechnol. 2022 May 16. doi: 10.2174/1389201023666220516121813. Online ahead of print.ABSTRACTThe idea of using the lytic power of viruses against malignant cells has been entertained for many decades. However, oncolytic viruses gained broad attention as an emerging anti-cancer therapy only recently with the successful implementation of several oncolytic viruses to treat advanced melanoma. Here we review the history of oncolytic viruses in the Russian Federation and recent biotechnological advances in connection with the perspectives of their practical use against aggressive tumors such as glioblastoma or pancr...
Source: Current Pharmaceutical Biotechnology - May 17, 2022 Category: Biotechnology Authors: Nadezhda M Kolyasnikova Nikolay B Pestov Jeanne M Sanchez-Pimentel Nikolay A Barlev Aidar A Ishmukhametov Source Type: research
Lutetium-177 radiopharmeceutical therapy extravasation lessons learned
Health Phys. 2022 Mar 22. doi: 10.1097/HP.0000000000001558. Online ahead of print.ABSTRACTLutetium-177 (177Lu) dotatate has been offered at Fox Chase Cancer Center since 2017 as part of a clinical trial and then in 2018 as a commercially available cancer therapy, and we thought we were prepared for most 177Lu issues by the fall of 2020. A single phone call identified that the Radiation Safety Department had not been prepared to address extravasations. Fortunately for the patient and Radiation Safety, the 177Lu therapies are administered by an infusion nurse and Fox Chase Cancer Center has a robust infusion center. The expe...
Source: Health Physics - March 23, 2022 Category: Physics Authors: Kendall Berry Jessica Kendrick Source Type: research
New insights into the relevance of mobile DNA to cancer resistance in blind mole rats: new lessons for cancer therapy
Cell Mol Immunol. 2022 Jan 7. doi: 10.1038/s41423-021-00830-5. Online ahead of print.NO ABSTRACTPMID:34992282 | DOI:10.1038/s41423-021-00830-5
Source: Cellular and Molecular Immunology - January 7, 2022 Category: Molecular Biology Authors: Victor M Arce Jose A Costoya Source Type: research
50 years of radiotherapy research: evolution, trends and lessons for the future
Radiother Oncol. 2021 Oct 4:S0167-8140(21)08747-8. doi: 10.1016/j.radonc.2021.09.026. Online ahead of print.ABSTRACTRapid and relentless technological advances in an ever-more globalized world have shaped the field of radiation oncology in which we practise today. These developments have drastically modified the habitus† of health professionals and researchers at an individual and organisational level. In this article we present an analysis of trends in radiation oncology research over the last half a century. To do so, the data from >350,000 scientific publications pertaining to a yearly search of the PubMed database...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - October 7, 2021 Category: Radiology Authors: Thomas Berger David J Noble Leila E A Shelley Kirsten I Hopkins Duncan B McLaren Neil G Burnet William H Nailon Source Type: research
Multidisciplinary Care of BRAF-Mutant Stage III Melanoma: A Physicians Perspective Review
Oncologist. 2021 Jun 3. doi: 10.1002/onco.13852. Online ahead of print.ABSTRACTPrognosis among patients with stage III melanoma can vary widely depending on the risk of disease relapse. Therefore, it is vital to optimize patient care through accurate diagnosis and staging as well as thoughtful treatment planning. A multidisciplinary team (MDT) approach, which involves active collaboration among physician specialists across a patient's disease journey, has been increasingly adopted as the standard of care for treatment of a variety of cancers, including melanoma. This review provides an overview of MDT care principles for p...
Source: The Oncologist - June 3, 2021 Category: Cancer & Oncology Authors: Lynn A Cornelius Ryan C Fields Ahmad Tarhini Source Type: research
