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Monoclonal Antibodies that Neutralize Norovirus
Vaccines and therapies to prevent and treat Norovirus infections do not exist, despite the worldwide prevalence of Norovirus infections. Outbreaks of human gastroenteritis attributable to Norovirus commonly occur in group setting, such as hospitals, nursing homes, schools, dormitories, cruise ships and military barracks.This technology relates to chimpanzee-human chimeric monoclonal antibodies, which specifically bind to Norovirus and have therapeutic potential. The antibodies that were tested in a primate model of infection have shown protection against Norovirus. These Norovirus antibodies may have application as immunop...
Source: NIH OTT Licensing Opportunities - January 23, 2017 Category: Research Authors: ajoyprabhu3 Source Type: research
Single-Chain Antibodies Directed to Norovirus GI.1 and GII.4 and Their Use
Vaccines and therapies to prevent and treat Norovirus infections are not available, despite the worldwide prevalence of Norovirus infections. Outbreaks of human gastroenteritis attributable to Norovirus commonly occur in group settings, such as hospitals, nursing homes, schools, dormitories, cruise ships and military barracks. This application claims isolated VHH monoclonal antibodies that specifically bind to a Norovirus polypeptide. Llama-derived single chain antibody fragments (also called VHH) are small, recombinant monoclonal antibodies of 15 kDa ( “nanobodies”) with several advantages over conventional antibodies...
Source: NIH OTT Licensing Opportunities - March 1, 2017 Category: Research Authors: ajoyprabhu3 Source Type: research
Dental students' knowledge regarding the indications for antibiotics in the management of endodontic infections
ConclusionsIt is necessary for the Spanish Schools of Dentistry to improve students' knowledge about antibiotics and their indications in endodontics. Interactive education analysing real endodontic cases using problem‐based learning would help students acquire better skills in prescribing antibiotics in pulp‐periapical pathosis.This article is protected by copyright. All rights reserved.
Source: International Endodontic Journal - April 4, 2017 Category: Dentistry Authors: M. Mart ín‐Jiménez, B. Martín‐Biedma, J. López‐López, O. Alonso‐Ezpeleta, E. Velasco‐Ortega, M.C. Jiménez‐Sánchez, J. J Segura‐Egea Tags: Original Scientific Article Source Type: research
Mylan sued by French drug manufacturer
The EpiPen controversy has led to another lawsuit against Mylan NV, this time by a French drug manufacturer.
Sanofi (NYSE: SNY) said in a lawsuit filed in federal court in Trenton, New Jersey, that Mylan (Nasdaq: MYL), which is based in The Netherlands but run out of corporate offices in Canonsburg, offered rebates for the anti-allergy medication and ads to get doctors and schools to keep EpiPen as the g o-to medication instead of a similiar medication that is owned by Sanofi.
"To preserve the monopoly…
Source: bizjournals.com Health Care:Physician Practices headlines - April 25, 2017 Category: American Health Authors: Paul J. Gough Source Type: news
Dental students ’ knowledge regarding the indications for antibiotics in the management of endodontic infections
ConclusionsIt is necessary for the Spanish schools of dentistry to improve students’ knowledge about antibiotics and their indications in endodontics. Interactive education analysing real endodontic cases using problem‐based learning would help students acquire better skills in prescribing antibiotics in pulp–periapical pathosis.
Source: International Endodontic Journal - April 25, 2017 Category: Dentistry Authors: M. Mart ín‐Jiménez, B. Martín‐Biedma, J. López‐López, O. Alonso‐Ezpeleta, E. Velasco‐Ortega, M. C. Jiménez‐Sánchez, J. J. Segura‐Egea Tags: Original Scientific Article Source Type: research
Peanut-free schools: What does it really mean, and are they necessary?
Source: Journal of Allergy and Clinical Immunology - April 25, 2017 Category: Allergy & Immunology Authors: David R. Stukus Source Type: research
Rationale for Development of Work-Related Asthma Educational Tools for Asthmatics
Opinion statementCurrently, young asthmatics have little knowledge of the potential effects of work exposures on their asthma. We expect that education of young asthmatics about the potential effects of the working environment on their asthma and appropriate steps to reduce work-related exacerbations will provide these individuals with skills to better control their asthma. Currently, there is no formal process for this education to our knowledge. Since the Internet is readily available and widely used by most young asthmatics, it may provide a useful forum for such education. Our preliminary studies with development and e...
Source: Current Treatment Options in Allergy - May 3, 2017 Category: Allergy & Immunology Source Type: research
A new approach to specific IgE testing, asthma and auto ‐injectors in schools
Source: Clinical and Experimental Allergy - July 28, 2017 Category: Allergy & Immunology Authors: G. Roberts Tags: EDITOR ‐IN‐CHIEF'S EDITORIAL Source Type: research
Schools allowed to keep spare allergy pens under new law
Children with severe allergies will have access to a spare adrenaline auto-injector in an emergency.
Source: BBC News | Health | UK Edition - September 29, 2017 Category: Consumer Health News Source Type: news
Psychological and lifestyle risk factors for asthma exacerbations and morbidity in children
AbstractAsthma is the most common childhood illness and disproportionately affects low-income, minority children who live in urban areas. A range of risk factors are associated with asthma morbidity and mortality, such as treatment non-adherence, exposure to environmental triggers, low-income households, exposure to chronic stress, child psychological problems, parental stress, family functioning, obesity, physical inactivity, and unhealthy diets. These risk factors often have complex interactions and inter-relationships. Comprehensive studies that explore the inter-relationships of these factors in accounting for asthma m...
Source: World Allergy Organization Journal - October 16, 2017 Category: Allergy & Immunology Source Type: research
P015 Improvements in the proper management of anaphylaxis in schools: results from the EpiPen4Schools ® survey
Medical guidelines agree on several steps that need to be taken in the event of anaphylaxis, including administering an epinephrine auto-injector (EAI), calling for help, and, if necessary, administering an additional EAI. To help improve preparedness of schools to properly manage anaphylaxis, the EpiPen4Schools ® program was initiated in 2012 to provide stock EAIs and educational materials to US schools.
Source: Annals of Allergy, Asthma and Immunology - October 27, 2017 Category: Allergy & Immunology Authors: M. White, C. Herrem, R. Muniz Source Type: research
Comparison physical activity barriers in asthmatic and non-asthmatic children
Conclusion: Environmental barriers are main factors that hamper physical activity in both groups. These findings may provide the basis for health professionals and public policy managers develop strategies for promoting physical activity in children.
Source: European Respiratory Journal - December 6, 2017 Category: Respiratory Medicine Authors: Sousa, A., Cabral, A. L., Carvalho, C., Martins, M. Tags: Paediatric Asthma and Allergy Source Type: research
Creating asthma friendly environment for children with asthma in Belgrade
Conclusion: audiovisual education was a successful way to transfer knowledge, improve control of child’s asthma and change attitude towards asthma and medications in parents and children with asthma.
Source: European Respiratory Journal - December 6, 2017 Category: Respiratory Medicine Authors: Radic, S., Milenkovic, B., Medjo, B., Vlahovic, O., Neskovic, A., Micic Stanojevic, M. Tags: Paediatric Asthma and Allergy Source Type: research
Association of leptin with disease severity and inflammation indicators in Chinese obese children with allergic rhinitis
ConclusionsOur study shows that obesity exacerbates inflammation and contributes to disease severity in AR. Our study provides evidence that leptin was involved in enhanced TH inflammation as well as the accumulation and activation of inflammatory cells in obese children with AR.This article is protected by copyright. All rights reserved.
Source: Pediatric Allergy and Immunology - December 1, 2017 Category: Allergy & Immunology Authors: Wenlong Liu, Qingxiang Zeng, Lifeng Zhou, Renzhong Luo, Haipeng Dong Tags: Original Article Source Type: research
Risk of Anaphylaxis Risk In Schools – A Systematic Review
Anaphylaxis is a rapid-onset systematic allergic reaction that may cause death. We sought to systematically evaluate the risk of anaphylaxis in schools.
Source: Journal of Allergy and Clinical Immunology - February 1, 2018 Category: Allergy & Immunology Authors: Derek K. Chu, Heather Cruickshank, Jan Brozek, Susan Waserman Source Type: research
