Filtered By:
Education: Grants

This page shows you your search results in order of date. This is page number 10.

Order by Relevance | Date

Total 146 results found since Jan 2013.

Control of NF‐kB activity in human melanoma by BET protein inhibitor I‐BET151
This article is protected by copyright. All rights reserved.
Source: Pigment Cell Research - May 1, 2014 Category: Cytology Authors: Stuart John Gallagher, Branka Mijatov, Dilini Gunatilake, Kavitha Gowrishankar, Jessamy Tiffen, Wilmott James, Lei Jin, Gulietta Pupo, Carleen Cullinane, Grant A McArthur, Peter J Tummino, Helen Rizos, Peter Hersey Tags: Original Article Source Type: research

HuR is Essential for TDP-43 Expression through Posttranscriptional Mechanisms: Implications for Motor Neuron Toxicity and ALS (1II-2.002)
Conclusions: 1. HuR is essential for proper expression of TDP-43. 2. HuR directly binds to TDP-43 mRNA and regulates its expression through the 3’ UTR. 3. Loss of HuR in astrocytes leads to the production of soluble factors that are toxic to cortical and motor neurons. These findings are consistent with our previous observations that impaired HuR function may contribute to ALS pathogenesis.Study supported by: Study supported by NIH/NINDS Grant NS057664.Disclosure: Dr. Lu has nothing to disclose. Dr. Zheng has nothing to disclose. Dr. Si has nothing to disclose. Dr. Oh has nothing to disclose. Dr. King has nothing to disclose.
Source: Neurology - April 9, 2014 Category: Neurology Authors: Lu, L., Zheng, L., Si, Y., Oh, S., King, P. Tags: Proteinopathy in Neurodegenerative Disease Data Blitz Presentations Source Type: research

HuR is Essential for TDP-43 Expression through Posttranscriptional Mechanisms: Implications for Motor Neuron Toxicity and ALS (S56.003)
Conclusions: 1. HuR is essential for proper expression of TDP-43. 2. HuR directly binds to TDP-43 mRNA and regulates its expression through the 3’ UTR. 3. Loss of HuR in astrocytes leads to the production of soluble factors that are toxic to cortical and motor neurons. These findings are consistent with our previous observations that impaired HuR function may contribute to ALS pathogenesis.Study supported by: Study supported by NIH/NINDS Grant NS057664.Disclosure: Dr. Lu has nothing to disclose. Dr. Zheng has nothing to disclose. Dr. Si has nothing to disclose. Dr. Oh has nothing to disclose. Dr. King has nothing to disclose.
Source: Neurology - April 9, 2014 Category: Neurology Authors: Lu, L., Zheng, L., Si, Y., Oh, S., King, P. Tags: Anterior Horn Disease Source Type: research

MicroRNA Let-7a and dicer are important in the activation and implantation of delayed implanting mouse embryos
STUDY QUESTION Does Let-7a have a functional role in modulating dicer expression to activate dormant mouse blastocysts for implantation? SUMMARY ANSWER Let-7a post-transcriptionally regulates dicer expression altering microRNA expression to affect the implantation competency of the activated blastocysts. WHAT IS KNOWN ALREADY The Let-7a microRNA is up-regulated during blastocyst dormancy and its forced-expression suppresses embryo implantation in vitro and in vivo. Dicer is a Let-7 target, which processes pre-microRNA to mature microRNA. STUDY DESIGN, SIZE, DURATION The effects on the expression of Let-7a and dicer in d...
Source: Human Reproduction - March 11, 2014 Category: Reproduction Medicine Authors: Cheong, A. W. Y., Pang, R. T. K., Liu, W.-M., Kottawatta, K. S. A., Lee, K.-F., Yeung, W. S. B. Tags: Reproductive biology Source Type: research

Abstract 441: Aldosterone-salt Hypertension Depends on the SFO, Central Aldosterone Synthase and MR Specifically in the PVN Poster Session II
We examined the role of the subfornical organ (SFO), aldo synthesized locally in the brain, and MR specifically in the paraventricular nucleus (PVN) in aldo-salt hypertension. Wistar rats with telemetry probes were treated with chronic intra-cerebroventricular infusion of aldo synthase (AS) inhibitor FAD286 (25 μg/day), MR blocker eplerenone (5 μg/day) or vehicle. After 2 days, subcutaneous (sc) aldo infusion (1 μg/h) was started and saline was provided as drinking water. In a second set of rats with telemetry, electrolytic or sham lesions of the SFO, or bilateral intra-PVN infusion of AAV-MR-siRNA or AAV-SCM-siRN...
Source: Hypertension - October 30, 2013 Category: Cardiology Authors: Huang, B. S., Ahmad, M., Chen, A., White, R. A., Leenen, F. H., Leenen, F. H. Tags: Poster Session II Source Type: research

Identification of CD147 (basigin) as a mediator of trophoblast functions
STUDY QUESTION Does CD147 regulate trophoblast functions in vitro? SUMMARY ANSWER CD147 exists as a receptor complex on human trophoblast and regulates the implantation, invasion and differentiation of trophoblast. WHAT IS KNOWN ALREADY CD147 is a membrane protein implicated in a variety of physiological and pathological conditions due to its regulation of cell–cell recognition, cell differentiation and tissue remodeling. Reduced placental CD147 expression is associated with pre-eclampsia, but the mechanism of actions remains unclear. STUDY DESIGN, SIZE, DURATION A loss of function approach or functional blocking ...
Source: Human Reproduction - October 11, 2013 Category: Reproduction Medicine Authors: Lee, C.-L., Lam, M. P. Y., Lam, K. K. W., Leung, C. O. N., Pang, R. T. K., Chu, I. K., Wan, T. H. L., Chai, J., Yeung, W. S. B., Chiu, P. C. N. Tags: Early pregnancy Source Type: research

ER{beta}-dependent effects on uterine endothelial cells are cell specific and mediated via Sp1
STUDY QUESTION What are the in vitro effects of estrogen receptor β (ERβ) activation on the function of endothelial cells (ECs) from different vascular beds: human endometrial ECs (HEECs; endometrium), uterine myometrial microvascular ECs (UtMVECs; myometrium) and human umbilical vein ECs (HUVECs)? SUMMARY ANSWER Studies conducted in vitro demonstrate that the ERβ agonist 2,3-bis(4-hydroxy-phenyl)-propionitrile (DPN) has EC type-specific effects on patterns of gene expression and network formation. Identification of a key role for the transcription factor Sp1 in ERβ-dependent signaling in uterine ECs o...
Source: Human Reproduction - August 21, 2013 Category: Reproduction Medicine Authors: Greaves, E., Collins, F., Critchley, H. O. D., Saunders, P. T. K. Tags: Reproductive biology Source Type: research

Knockdown of the co‐chaperone SGTA results in the suppression of androgen and PI3K/AKT signaling and inhibition of prostate cancer cell proliferation
This study provides insight into the biological actions of SGTA, its effect on genome‐wide AR transcriptional activity and other therapeutically targeted intracellular signaling pathways, whilst also providing evidence for PCa‐specific alterations in SGTA expression. © 2013 Wiley Periodicals, Inc.
Source: International Journal of Cancer - June 6, 2013 Category: Cancer & Oncology Authors: Andrew P. Trotta, Eleanor F. Need, Luke A. Selth, Samarth Chopra, Carole B. Pinnock, Damien A. Leach, Gerhard A Coetzee, Lisa M. Butler, Wayne D. Tilley, Grant Buchanan Tags: Cancer Cell Biology Source Type: research

Management of Hypercholesterolemia Utilizing a Home Lipid Monitoring System: Preliminary Findings*
None The study was funded by a research grant from Merck & Co.
Source: Journal of Clinical Lipidology - May 1, 2013 Category: Lipidology Authors: Mohamad A. Alkhouli, Brendan J. Carry, Harish Jarrett, Sara J. Sirna Tags: Abstracts Source Type: research

Targeting the IRE1α/XBP1 and ATF6 Arms of the Unfolded Protein Response Enhances VEGF Blockade to Prevent Retinal and Choroidal Neovascularization.
In conclusion, activation of the UPR sustains angiogenesis by preventing degradation of intracellular VEGF. The IRE1α/ATF6 arms of the UPR offer a potential therapeutic target in the treatment of pathological angiogenesis. PMID: 23395094 [PubMed - as supplied by publisher]
Source: The American Journal of Pathology - February 7, 2013 Category: Pathology Authors: Liu L, Qi X, Chen Z, Shaw L, Cai J, Smith LH, Grant MB, Boulton ME Tags: Am J Pathol Source Type: research

WNT10B/β‐catenin signalling induces HMGA2 and proliferation in metastatic triple‐negative breast cancer
Abstract Wnt/β‐catenin signalling has been suggested to be active in basal‐like breast cancer. However, in highly aggressive metastatic triple‐negative breast cancers (TNBC) the role of β‐catenin and the underlying mechanism(s) for the aggressiveness of TNBC remain unknown. We illustrate that WNT10B induces transcriptionally active β‐catenin in human TNBC and predicts survival‐outcome of patients with both TNBC and basal‐like tumours. We provide evidence that transgenic murine Wnt10b‐driven tumours are devoid of ERα, PR and HER2 expression and can model human TNBC. Importantly, HMGA2 is specifically exp...
Source: EMBO Molecular Medicine - January 11, 2013 Category: Molecular Biology Authors: Peter Wend, Stephanie Runke, Korinna Wend, Brenda Anchondo, Maria Yesayan, Meghan Jardon, Natalie Hardie, Christoph Loddenkemper, Ilya Ulasov, Maciej S. Lesniak, Rebecca Wolsky, Laurent A. Bentolila, Stephen G. Grant, David Elashoff, Stephan Lehr, Jean J. Tags: Research Article Source Type: research