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Total 611 results found since Jan 2013.
Lessons from Toxicology: Developing a 21st-Century Paradigm for Medical Research
Conclusions
Our proposed new research paradigm, adapted from 21st-century toxicology, would involve the following aspects:
Developing a big picture of human diseases, integrating extrinsic and intrinsic causes, and linking environmental sciences with medical research using systems biology.
Introducing a disease AOP concept, analogous to toxicity AOPs, with the intention of providing a unified framework for describing relevant pathophysiology pathways and networks across multiple biological levels.
Creating a strong focus on advanced human-specific research (in vitro, ex vivo, in vivo, and in silico) in place of empirical,...
Source: EHP Research - November 2, 2015 Category: Environmental Health Authors: Web Admin Tags: Brief Communication November 2015 Source Type: research
Non-glaucoma periocular allergic, atopic, and irritant dermatitis at an academic institution: A retrospective review.
CONCLUSION: Patients treated with topical steroid and oral antihistamine were approximately 4 times more likely to experience cure in comparison to patients treated with topical steroids alone. While the majority of patients were not referred for formal allergy testing, this would likely be of benefit.
PMID: 29985741 [PubMed - as supplied by publisher]
Source: Orbit - July 9, 2018 Category: Opthalmology Authors: Pandit SA, Glass LRD Tags: Orbit Source Type: research
A Bidirectional Label Propagation Based Computational Model for Potential Microbe-Disease Association Prediction
Discussion
There are numerous microbial communities inhabited in the human body, which is critical to human health. The relationship between human microbiome and diseases received much attention from both medical and bioinformatics community recently. However, traditional methods to detect their association is costly and labor-intensive. Thus, we proposed here a new computational model called NBLPIHMDA to infer potential microbe-disease associations. NBLPIHMDA first combined known microbe-disease associations in HMDAD and the Gaussian interaction profile kernel similarity to construct disease similarity network and microb...
Source: Frontiers in Microbiology - April 8, 2019 Category: Microbiology Source Type: research
A Comparison of Three Different Bioinformatics Analyses of the 16S –23S rRNA Encoding Region for Bacterial Identification
Conclusion
The higher resolution at the species level identification provided by 16S–23S rRNA encoding region NGS makes its use in routine diagnostic microbiology potentially attractive. Particularly, data analysis is one of the most important steps of a diagnostic workflow, which requires an optimal pipeline for the interpretation of the sequencing data in a short time. This study demonstrates that de novo assembly and subsequent BLASTN analysis using an in-house developed database compared to OTU clustering and mapping approaches is the most accurate and fastest approach for identification of bacterial pathogens....
Source: Frontiers in Microbiology - April 15, 2019 Category: Microbiology Source Type: research
Evaluation of AdvanSure AlloScreen Max Panel With 92 Different Allergens for Detecting Allergen-Specific IgE.
CONCLUSIONS: A MAST assay panel containing as many allergens as possible would be more helpful in the allergen screening for patients with high serum IgE concentration.
PMID: 30984971 [PubMed - as supplied by publisher]
Source: American Journal of Clinical Pathology - April 14, 2019 Category: Pathology Authors: Park DJ, Lee J, Kim SY, Kwon HJ, Lee HK, Kim Y Tags: Am J Clin Pathol Source Type: research
Editorial: Shaping of Human Immune System and Metabolic Processes by Viruses and Microorganisms
Conclusions
In conclusion, articles in this Research Topic made a very significant contribution to our understanding of the role played by environmental factors, dysbiotic conditions, and infections in triggering diseases. Since this is a rapidly expanding area of research, many other factors contributing to the onset of these diseases are not covered here. We are confident, however, that further studies will expand the list as well as bring a better understanding of mechanisms involved in the onset of autoimmune and autoinflammatory diseases.
Author Contributions
All authors listed have made a substantial, direct and i...
Source: Frontiers in Microbiology - April 16, 2019 Category: Microbiology Source Type: research
Functional Antibody Responses Following Allogeneic Stem Cell Transplantation for TP53 Mutant pre-B-ALL in a Patient With X-Linked Agammaglobulinemia
Discussion
This case demonstrates successful cure of pre-B-ALL complicating XLA by alloSCT with restoration of B-cell development and functional antibody response.
We are aware of only one previous case of pre-B-ALL in an XLA patient (21), which suggests that human BTK deficiency in itself does not predispose to pre-B-ALL. However, there are data to suggest that BTK may act as a tumor suppressor, and BTK deficiency may predispose to tumor development following a “second hit.” Mice with a genetic deficiency in Slp65, a gene encoding an adaptor protein that functions together with BTK, have a block in proge...
Source: Frontiers in Immunology - April 25, 2019 Category: Allergy & Immunology Source Type: research
LAIR-1 Limits Neutrophilic Airway Inflammation
In conclusion, the immune inhibitory receptor LAIR-1 suppresses neutrophil tissue migration and acts as a negative regulator of neutrophil-driven airway inflammation during lung diseases. Following our recent observations in humans, this study provides crucial in-vivo evidence that LAIR-1 is a promising target for pharmacological intervention in such pathologies.
Introduction
The lungs are constantly exposed to potential pathogens and other harmful agents. To protect against sudden incursions, neutrophils patrol the lung capillaries. A rapid and robust neutrophil response is crucial to antimicrobial defense (1, 2). N...
Source: Frontiers in Immunology - April 25, 2019 Category: Allergy & Immunology Source Type: research
Impact of a multidisciplinary workflow on safety and management of patients with heparin-induced thrombocytopenia.
CONCLUSION: Implementation of a multidisciplinary workflow for the management of HIT significantly reduced the incidence of heparin administration while testing was ongoing and improved the rate of appropriate heparin allergy documentation.
PMID: 33103184 [PubMed - as supplied by publisher]
Source: American Journal of Health-System Pharmacy : AJHP - October 26, 2020 Category: Drugs & Pharmacology Authors: Northam KA, Chen SL, Stivers AP, Cicci JD, Hedrick TL, Rollins-Raval MA, Kasthuri RS Tags: Am J Health Syst Pharm Source Type: research
A case series of perioperative anaphylaxis to cefazolin during kidney transplant and review of literature
CONCLUSION: Peri-or intraoperative anaphylaxis to Cefazolin is on the rise and its consequences in transplant candidates are even more dire given the pre-existing end organ failure, financial burden for health care system, potential loss of donor organs, and emotional burden for recipients and their families. These are the first two cases of reported Cefazolin-induced anaphylaxis that actually resulted in aborting the kidney transplant operation. In addition, cases of previously reported Type 1 hypersensitivity to Cefazolin as prophylaxis for operations were reviewed and the allergy workups were discussed.PMID:36126905 | D...
Source: Transplant Immunology - September 20, 2022 Category: Transplant Surgery Authors: Salman Salehin Anand Kumar Nantian Harsell Hamza Salim Syed A Hussain Michael Kueht Muhammad A Mujtaba Source Type: research
La Jolla Institute continues longtime collaboration with Kyowa Hakko Kirin California
(La Jolla Institute for Allergy and Immunology) La Jolla Institute for Allergy and Immunology and Kyowa Hakko Kirin California, Inc., a wholly-owned subsidiary of Kyowa Hakko Kirin Co., Ltd., a global specialty pharmaceutical company, today announced the signing of a new agreement that marks another milestone in one of the most enduring industry-academic collaborations in the world.
Source: EurekAlert! - Medicine and Health - July 30, 2013 Category: Global & Universal Source Type: news
Canadian guidelines for chronic rhinosinusitis: Clinical summary.
CONCLUSION: The Canadian guidelines provide diagnosis and treatment approaches based on the current understanding of the disease and available evidence. Additionally, the guidelines provide the expert opinion of a diverse group of practice and academic experts to help guide clinicians where evidence is sparse.
PMID: 24336538 [PubMed - in process]
Source: Canadian Family Physician Medecin de Famille Canadien - December 1, 2013 Category: Primary Care Authors: Kaplan A Tags: Can Fam Physician Source Type: research
A Consensus Parameter for the Evaluation and Management of Angioedema in the Emergency Department / Un Parámetro de Consenso para la Evaluación y Tratamiento del Angioedema en el Servicio de Urgencias
Abstract
Despite its relatively common occurrence and life‐threatening potential, the management of angioedema in the emergency department (ED) is lacking in terms of a structured approach. It is paramount to distinguish the different etiologies of angioedema from one another and more specifically differentiate histaminergic‐mediated angioedema from bradykinin‐mediated angioedema, especially in lieu of the more novel treatments that have recently become available for bradykinin‐mediated angioedema. With this background in mind, this consensus parameter for the evaluation and management of angioedema attempts to pro...
Source: Academic Emergency Medicine - April 14, 2014 Category: Emergency Medicine Authors: Joseph J. Moellman, Jonathan A. Bernstein, Christopher Lindsell, Aleena Banerji, Paula J. Busse, Carlos A. Camargo, Sean P. Collins, Timothy J. Craig, William R. Lumry, Richard Nowak, Jesse M. Pines, Ali S. Raja, Marc Riedl, Michael J. Ward, Bruce L. Zura Tags: Special Contribution Source Type: research
Racial and Ethnic Disparities in Research Studies: The Challenge of Creating More Diverse Cohorts
This reporting project was funded through a grant provided by the Reporting Award at New York University’s Arthur L. Carter Journalism Institute.
Background image: Bahri Altay/Shutterstock
About This Article open
Citation: Konkel L. 2015. Racial and ethnic disparities in research studies: the challenge of creating more diverse cohorts. Environ Health Perspect 123:A297–A302; http://dx.doi.org/10.1289/ehp.123-A297
Published: 1 December 2015
PDF Version (873 KB)
Minority populations are much less likely than their white counterparts to be included in studies on environmentally related diseases, even t...
Source: EHP Research - December 1, 2015 Category: Environmental Health Authors: Web Admin Tags: Featured News Spheres of Influence December 2015 Source Type: research
Increased Surgical Site Infection Rates following Clindamycin Use in Head and Neck Free Tissue Transfer
Conclusion
For patients with a true penicillin allergy, we recommend broader gram-negative coverage with alternative antibiotics, such as cefuroxime, when undergoing free tissue transfer in the head and neck.
Source: Otolaryngology - Head and Neck Surgery - February 1, 2016 Category: ENT & OMF Authors: Pool, C., Kass, J., Spivack, J., Nahumi, N., Khan, M., Babus, L., Teng, M. S., Genden, E. M., Miles, B. A. Tags: Facial Plastic and Reconstructive Surgery Source Type: research
