• Filter By:
• Specialty
• Source
• Condition
• Cancer
• Infectious Disease
• Drug
• Training
• Management
• Procedure
• Therapy
• Vaccine
• Nutrition
• Country

What Are Causes of Childhood Interstital Lung Disease?
Discussion Interstitial lung disease in children (chILD) is less understood than adult interstitial lung disease (ILD) and is rare. Prevalence is ~ 0.13 to 16.2 per 100,000 children under age 17 years. chILD is an general term for respiratory disorders that are heterogeneous, chronic and impair lung function. While some define diffuse parenchymal lung disease (DPLD) separately, the term ILD usually encompases DPLD. chILD has variable definitions and is “usually diagnosed if three of the following features are present: 1) respiratory symptoms (cough, rapid and/or difficult breathing, and exercise intolerance), 2) res...
Source: PediatricEducation.org - August 1, 2022 Category: Pediatrics Authors: Pediatric Education Tags: Uncategorized Source Type: news

Insights into HM and PHM fellowship programs
A hospital medicine fellowship combines the best of hospital medicine with the opportunity for physicians to specialize early in their careers.  According to directors of successful programs at the University of California, San Francisco (UCSF), Deaconess Hospital, the Medical College of Wisconsin, and Akron Children’s Hospital, the best fellowship programs benefit the hospital as well as the fellow. These directors shared their ideas on creating and optimizing fellowships, notably in the establishment of pediatric hospital medicine (PHM) programs, which are a relatively new option. Opportunities for enrichment Dr. Fan...
Source: The Hospitalist - February 3, 2022 Category: Hospital Management Authors: Ronda Whitaker Tags: Career Source Type: research

Plant-Derived Alkaloids: The Promising Disease-Modifying Agents for Inflammatory Bowel Disease
Conclusion This paper summarizes the current findings regarding the anti-colitis activity of plant-derived alkaloids and shows how these alkaloids exhibit significant and beneficial effects in alleviating colonic inflammation. These natural alkaloids are not only promising agents for IBD treatment but are also components for developing new wonder drugs. However, the underlying molecular mechanisms or toxicological evaluation of most plant-derived alkaloids still require much scientific research, and their actual efficacies for IBD patients have not been verified well in field research. Thus, further clinical trials to elu...
Source: Frontiers in Pharmacology - April 11, 2019 Category: Drugs & Pharmacology Source Type: research

Lactobacillus plantarum KLDS1.0318 Ameliorates Impaired Intestinal Immunity and Metabolic Disorders in Cyclophosphamide-Treated Mice
Conclusion In conclusion, the present study showed that the oral administration of L. plantarum KLDS1.0318 normalized the parameters altered by CTX-induced toxicities, strengthening intestinal health by regulating the Th1/Th2 balance, ameliorating the intestinal morphology and improving profiles of intestinal microbiota and metabolism. Therefore, our findings suggested that the administration of L. plantarum KLDS1.0318 could be of significant advantage in reducing intestinal immunity impairment caused by cyclophosphamide. Ethics Statement This study was carried out according to the Animal Care Review Committee, Northeas...
Source: Frontiers in Microbiology - April 11, 2019 Category: Microbiology Source Type: research

Individual and Joint Effects of Early-Life Ambient PM2.5 Exposure and Maternal Prepregnancy Obesity on Childhood Overweight or Obesity
Conclusions: In the present study, we observed that early life exposure to PM2.5 may play an important role in the early life origins of COWO and may increase the risk of COWO in children of mothers who were overweight or obese before pregnancy beyond the risk that can be attributed to MPBMI alone. Our findings emphasize the clinical and public health policy relevance of early life PM2.5 exposure. https://doi.org/10.1289/EHP261 Received: 29 March 2016 Revised: 08 August 2016 Accepted: 23 August 2016 Published: 14 June 2017 Address correspondence to X. Wang, Center on the Early Life Origins of Disease, Department of P...
Source: EHP Research - June 14, 2017 Category: Environmental Health Authors: Daniil Lyalko Tags: Research Source Type: research

A congenital purplish tumour
An ethnic Bengali baby boy presented at birth with a purplish tender lesion on the medial side of his right knee (figure 1A). In the following weeks, the lesion remained stable in size. An ultrasound scan showed a solid mass, slightly heterogeneous, with a vascular pole but no bone involvement (figure 1B). Question 1 What is your diagnosis?Congenital haemangioma Vascular malformations Infantile myofibroma Malignant tumours Tufted angioma Answer 1 The correct answer is E. Tufted angioma (TA) represents a benign vascular tumour that may be congenital, acquired, sporadic or hereditary.1 It usually occurs during infancy or ear...
Source: Archives of Disease in Childhood - Education and Practice - March 19, 2017 Category: Pediatrics Authors: Matarazzo, L., Delise, A., Zennaro, F., Bussani, R., Demarini, S., Berti, I., Ventura, A. Tags: Oncology, Surgery, Immunology (including allergy), Child health, Pathology, Radiology, Dermatology, Surgical diagnostic tests, Clinical diagnostic tests, Radiology (diagnostics) Epilogue Source Type: research

Critical Asthma Syndrome in the ICU
Abstract Critical asthma syndrome represents the most severe subset of asthma exacerbations, and the critical asthma syndrome is an umbrella term for life-threatening asthma, status asthmaticus, and near-fatal asthma. According to the 2007 National Asthma Education and Prevention Program guidelines, a life-threatening asthma exacerbation is marked by an inability to speak, a reduced peak expiratory flow rate of <25 % of a patient’s personal best, and a failed response to frequent bronchodilator administration and intravenous steroids. Almost all critical asthma syndrome cases require emergency care, and mos...
Source: Clinical Reviews in Allergy and Immunology - January 24, 2015 Category: Allergy & Immunology Source Type: research