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Drug: Prednisolone
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Total 367 results found since Jan 2013.
Intracameral moxifloxacin after cataract surgery: a prospective study
Conclusion: The results suggest moxifloxacin is a safe option for intracameral use after cataract surgery.RESUMO Objetivo: Estudar alguns par âmetros de segurança da moxifloxacino intracameral nas cinco semanas após a cirurgia de catarata. Métodos: O estudo foi uma série de casos prospectivos. O cenário era um hospital privado em Recife, Pernambuco, Brasil. Foi considerada uma amostra consecutiva de 1.016 cirurgias de catarata. Os critérios de inclusão foram pacientes com indicação para cirurgia de catarata, com pelo menos 55 anos de idade e sem história de alergia a quinolonas. Os pacientes foram preparados par...
Source: Arquivos Brasileiros de Oftalmologia - May 29, 2018 Category: Opthalmology Source Type: research
Short Course Of Oral Prednisolone Improves Physician Reported Clinical Scores and Patient Reported Outcomes in Patients with Moderate-to-Severe Atopic Dermatitis
Oral steroid is the only non-biologic immunomodulator approved by the FDA for treatment of atopic dermatitis (AD). However, no studies have examined the effects of a short course of prednisolone in patients with AD on physician and patient reported outcomes.
Source: Journal of Allergy and Clinical Immunology - February 1, 2019 Category: Allergy & Immunology Authors: Emma Price, Sai Sakktee Krisna, Karen J. Howie, Rashie Brar, Eman Alasgah, Caroline Munoz, Paul M. O'Byrne, Roma Sehmi, Gail M. Gauvreau, Hermenio Lima Source Type: research
High oral corticosteroid exposure and overuse of short-acting beta-2-agonists were associated with insufficient prescribing of controller medication: a nationwide electronic prescribing and dispensing database analysis
ConclusionsExposure to high-dose of OCS (101 per 100,000 patients) and SABA over-use (24 per 100,000) were frequent, and were associated with a low maintenance-to-total prescription ratio but not with primary non-adherence. These results suggest there is a need for initiatives to reduce OCS and SABA inappropriate prescribing.
Source: Clinical and Translational Allergy - September 22, 2019 Category: Allergy & Immunology Source Type: research
M063 oral budesonide desensitization: a case report
The incidence of glucocorticoid hypersensitivity reaction is approximately 0.1%. Among various glucocorticoids, the incidence of hypersensitivity appears to be highest for prednisone, prednisolone, hydrocortisone, and methylprednisolone. Budesonide is generally well tolerated. Budesonide has been reported to cause delayed-type hypersensitivity reactions, however, there have not been many reports of immediate-type hypersensitivity reactions. There are no published protocols for budesonide desensitization.
Source: Annals of Allergy, Asthma and Immunology - October 31, 2019 Category: Allergy & Immunology Authors: P. Sandhu, S. Brady Source Type: research
Retrospective study on the combined use of voriconazole and prednisolone in the treatment of acute allergic bronchopulmonary aspergillosis (ABPA)
Three years ago we started treating patients diagnosed with ABPA, an allergic lung disease provoked by Aspergillus fumigatus (Af), with a combined therapy of voriconazole and prednisolone. We used voriconazole at a dose of 200 mg twice a day for 4 months, while the initial prednisolone dose was 0.75 mg/kg/day for 1 month, then 0.25 mg/kg/day for 1 month, then progressive tapering (5 mg each fortnight) until the minimum dose of 5 mg/day, maintained until the fourth month. We evaluated patients at 6 months from the end of therapy. We enrolled 25 patients in the disease acute phase, who had never used azol therapy before, wit...
Source: European Respiratory Journal - November 20, 2019 Category: Respiratory Medicine Authors: Bini, F., Visca, D., Grassi, N., De Lauretis, A., Spanevello, A., Vaghi, A. Tags: Allergy and immunology Source Type: research
Low prevalence of obstructive sleep apnoea in paediatric severe therapy resistant asthma
Discussion: The prevalence and severity of OSA in our cohort of STRA children was lower than published in unselected asthmatics. This may reflect their proven good adherence to high dose anti-inflammatory medication at the time of their sleep study.
Source: European Respiratory Journal - November 20, 2019 Category: Respiratory Medicine Authors: Grime, C., Garbato, G., Rosenthal, M., Saglani, S., Fleming, L., Tan, H.-L. Tags: Paediatric asthma and allergy Source Type: research
Dexamethasone or prednisolone for acute asthma exacerbations in children: a meta-analysis
Conclusion: Oral dexamethasone is as effective as prednisolone for acute asthma in children, and is better tolerated.
Source: European Respiratory Journal - November 20, 2019 Category: Respiratory Medicine Authors: Nitchingham, D., Hawcutt, D., Fernandes, R., Kapitein, B., Andrew, L., Grice, J., Cibinda, H., OConnor, M., Sinha, I. Tags: Paediatric asthma and allergy Source Type: research
Assessment of Treatment Response in Granulomatous Lymphocytic Interstitial Lung Disease (GLILD)
Conclusion: Prednisolone improves lung function in GLILD but responses are heterogeneous. The greatest initial changes are observed in spirometry than gas transfer.Reference:Hurst JR, et al. BLF/UKPIN Consesus Statement, J Allergy Clin Immunol Pract. 2017 Jul - Aug;5(4):938-945
Source: European Respiratory Journal - November 20, 2019 Category: Respiratory Medicine Authors: Gkrepi, G., Lowe, D. M., Burns, S., Seneviratne, S., Hurst, J. R. Tags: Rare ILD/DPLD Source Type: research
Late Breaking Abstract - Matrix metalloproteinases in serum and sputum reflect distinct processes of relevance to asthma
Conclusion: As local airway MMPs emerge as biomarkers of novel asthma phenotypes we find that serum and sputum MMPs differ regarding associations with disease severity and steroid use. Serum MMP-3 stands out as being strongly upregulated by steroid use, questioning its usefulness and highlighting a need to determine therapeutic effects on new biomarkers.
Source: European Respiratory Journal - November 20, 2019 Category: Respiratory Medicine Authors: James, A., Gomez, C., Thörngren, J.-O., Ericsson, M., Kolmert, J., Wheelock, C., Knowles, R., Adcock, I., Dahlen, S.-E., U-Biopred & Bioair Study Groups, . Tags: Allergy and immunology Source Type: research
Evaluation of the Anti-Inflammatory Activities of Diclofenac Sodium, Prednisolone and Atorvastatin in Combination with Ascorbic Acid
Source: Anti-Inflammatory and Anti-Allergy Agents in Medicinal Chemistry - September 7, 2020 Category: Allergy & Immunology Authors: Ahmed, Tanvir Archie, Sabrina R. Faruk, Asef Chowdhury, Fabliha Ahmed Al Shoyaib, Abdullah Ahsan, Chowdhury Rafiqul Tags: Research article Source Type: research
Dual Monoclonal Antibody Therapy for a Severe Asthma Patient
ConclusionsIn some severe allergic asthma patients with persistently high eosinophil counts in peripheral blood and who are considered non- or mild responders to anti-IgE and anti-IL5 administered individually, a combination of the two antibodies covering the entire T2 spectrum may be effective.
Source: Frontiers in Pharmacology - September 29, 2020 Category: Drugs & Pharmacology Source Type: research
The impact of depression in patients with severe asthma (SA) in the Wessex Severe Asthma Cohort (WSAC)
Discussion: SA patients with depression report poorer disease control & QOL associated with a greater burden of co-morbidities including obesity, rhinosinusitis & reflux. However, no statistically significant differences were identified in their other clinical or physiological characteristics. Inflammatory phenotypes did not differ between the groups but those with depression were found to have significantly higher serum hs-CRP & sputum IL-6 levels (not seen when subdivided for BMI). There is a well-recognised association between inflammation & depression with elevated serum IL-6 levels previously reported....
Source: European Respiratory Journal - October 28, 2020 Category: Respiratory Medicine Authors: Wiffen, L., Brown, T., Fox, L., Jones, T., Gove, K., Barber, C., Rupani, H., Elliott, S., Chauhan, A., Howarth, P. Tags: Allergy and immunology Source Type: research
Treatment of naturally occurring asthma with inhaled fluticasone or oral prednisolone: A randomized pilot trial.
The objective of this study was to compare inhaled glucocorticoids with oral glucocorticoids for treatment of naturally occurring feline asthma. Secondary goals were to evaluate serum allergy testing results in cats and to quantify the effect of an inhaled glucocorticoid (fluticasone) on glucose homeostasis. Nine cats with asthma were enrolled on the basis of clinical signs, thoracic radiographic findings, and airway eosinophilia. Cats were randomized and 4 cats were treated with oral glucocorticoids and 5 cats with inhaled glucocorticoids, with a 7-day course of oral glucocorticoids overlapping at the start of therapy. Ca...
Source: Canadian Journal of Veterinary Research - January 1, 2021 Category: Veterinary Research Authors: Verschoor-Kirss M, Rozanski EA, Sharp CR, Oura TJ, Egan A, Bain P, Knoll J Tags: Can J Vet Res Source Type: research
The Effect Of Prednisolone Treatment On Histopathological Outcomes In Skin Of Patients With Atopic Dermatitis
We examined the effect of prednisolone on histological outcomes in skin of patients with atopic dermatitis.
Source: Journal of Allergy and Clinical Immunology - February 1, 2021 Category: Allergy & Immunology Authors: Christiane Whetstone, Nadia Alsaji, Emma Price, Ruth Cusack, Roma Sehmi, Hermenio Lima, Gail Gauvreau Source Type: research
Prednisolone Treatment Reduces Type 2 Inflammation In Skin Lesions Of Patients With Atopic Dermatitis
We examined the effect of prednisolone on eosinophils, eosinophil progenitors (EoPs), basophils and cytokines in chronic AD lesions and clinical scores to understand the relationship between eosinophilia and disease severity.
Source: Journal of Allergy and Clinical Immunology - February 1, 2021 Category: Allergy & Immunology Authors: Emma Price, Christiane Whetstone, Dhuha Al-Sajee, Sai Sakktee Krisna, Karen Howie, Caroline Munoz, Paul O'Byrne, Hermenio Lima, Roma Sehmi, Gail Gauvreau Source Type: research
