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Drug: Methotrexate
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Medical News Today: Is chemotherapy effective for rheumatoid arthritis?
Chemotherapy drugs, such as methotrexate, are one of the first-line treatments for people with rheumatoid arthritis. These drugs can help relieve symptoms and prevent further joint damage. However, they can cause a number of side effects, and doctors will closely monitor people on these drugs. Learn more here.
Source: Health News from Medical News Today - June 20, 2019 Category: Consumer Health News Tags: Rheumatoid Arthritis Source Type: news
Medical News Today: How does methotrexate affect pregnancy?
It is not safe to take methotrexate during pregnancy. The drug affects folic acid levels in the body and can lead to birth abnormalities. In this article, we look at the effects of taking methotrexate during conception or pregnancy, how to stay safe, and alternative medications.
Source: Health News from Medical News Today - June 25, 2019 Category: Consumer Health News Tags: Rheumatoid Arthritis Source Type: news
Hormonal Used in Place of Chemotherapy for Ectopic Pregnancy Hormonal Used in Place of Chemotherapy for Ectopic Pregnancy
An aromatase inhibitor is a safe and effective way to end an ectopic pregnancy, with a better safety profile than methotrexate, ' breakthrough ' results from a small study show.Medscape Medical News
Source: Medscape Medical News Headlines - November 25, 2019 Category: Consumer Health News Tags: Ob/Gyn & Women ' s Health News Source Type: news
Treatment and its side effects in ANCA-associated vasculitides – Study based on POLVAS registry data
ConclusionsPolish patients with AAV were predominantly treated according to appropriate guidelines. The most frequent adverse events were typical for usually administered immunosuppressive treatment.
Source: Advances in Medical Sciences - January 18, 2020 Category: Biomedical Science Source Type: research
Choosing the Best Blood Pressure Target for Vasopressor Therapy
Medical research drives innovation and improves outcomes. In cardiology, advances in diagnosis, prevention, and treatment reduced the 30-day mortality from acute myocardial infarction from 20% to 12.4% between 1995 and 2014. Similarly, for women diagnosed with breast cancer, 5-year survival has increased from 74% to 88.5% over the past 4 decades in parallel with advances in diagnosis and targeted therapy, including chemotherapeutic regimens such as cyclophosphamide, methotrexate, and fluorouracil (CMF), trastuzumab, and aromatase inhibiors.
Source: JAMA - Journal of the American Medical Association - February 12, 2020 Category: General Medicine Source Type: research
Supercritical fluid technology for the development of innovative ophthalmic medical devices: Drug loaded intraocular lenses to mitigate posterior capsule opacification.
Abstract
Supercritical impregnation technology was applied to load acrylic intraocular lenses (IOLs) with methotrexate to produce a sustained drug delivery device to mitigate posterior capsule opacification. Drug release kinetics were studied in vitro and used to determine the drug loading. Loaded IOLs and control IOLs treated under the same operating conditions, but without drug, were implanted ex vivo in human donor capsular bags. The typical cell growth was observed and immunofluorescence staining of three common fibrosis markers, fibronectin, F-actin and α-smooth muscle actin was carried out. Transparent IOLs...
Source: European Journal of Pharmaceutics and Biopharmaceutics - February 25, 2020 Category: Drugs & Pharmacology Authors: Ongkasin K, Masmoudi Y, Wertheimer CM, Hillenmayer A, Eibl-Lindner KH, Badens E Tags: Eur J Pharm Biopharm Source Type: research
TNF Inhibitor Plus Methotrexate Surpassed Monotherapy in PsA TNF Inhibitor Plus Methotrexate Surpassed Monotherapy in PsA
The addition of a TNF inhibitor to the treatment regimen of patients with psoriatic arthritis (PsA) improves the achievement of minimal disease activity, new research shows.Medscape Medical News
Source: Medscape Medical News Headlines - June 10, 2020 Category: Consumer Health News Tags: Rheumatology News Source Type: news
No Link Between Methotrexate, Interstitial Lung Disease in RA No Link Between Methotrexate, Interstitial Lung Disease in RA
Patients with rheumatoid arthritis are at elevated risk for interstitial lung disease, but methotrexate does not accentuate that risk and may be protective, new data show.Medscape Medical News
Source: Medscape Medical News Headlines - June 11, 2020 Category: Consumer Health News Tags: Pulmonary Medicine News Source Type: news
Methotrexate Treat-and-Extend Tested for Vitreoretinopathy Methotrexate Treat-and-Extend Tested for Vitreoretinopathy
A methotrexate protocol that involves treat-and-extend dosing can be used to successfully treat proliferative vitreoretinopathy, a case series shows.Medscape Medical News
Source: Medscape Medical News Headlines - July 27, 2020 Category: Consumer Health News Tags: Ophthalmology News Source Type: news
Medical research and reproductive medicine in an ethical context: a critical commentary on the paper dealing with uterine lavage published by Munn é et al.
AbstractA recent study published in Human Reproduction claimed that uterine lavage offers a non-surgical, minimally invasive strategy for the recovery of human embryos from fertile women who do not want or need IVF for medical reasons but who desire preimplantation genetic testing (PGT) for embryos. To prove this hypothesis, the researchers recruited dozens of young Mexican women. The prospective oocyte donors underwent ovarian stimulation to induce the production of multiple mature oocytes. Subsequently, these women were inseminated by donor semen. A few days later, the developing embryos were collected by uterine lavage ...
Source: Journal of Assisted Reproduction and Genetics - October 5, 2020 Category: Reproduction Medicine Source Type: research
Methotrexate Users Need Tuberculosis Tests in High-TB Areas Methotrexate Users Need Tuberculosis Tests in High-TB Areas
Those taking corticosteroids or other immunosuppressants are at particularly high risk, a systematic review of literature finds.Medscape Medical News
Source: Medscape Medical News Headlines - November 7, 2020 Category: Consumer Health News Tags: Rheumatology News Source Type: news
Proposed RA Guidelines: Maximize Methotrexate Before Switching Proposed RA Guidelines: Maximize Methotrexate Before Switching
Use methotrexate aggressively before switching to a biologic or JAK inhibitor, authors propose in guidelines, updated from 2015, for rheumatoid arthritis. They also urge moving away from prednisone.Medscape Medical News
Source: Medscape Medical News Headlines - November 9, 2020 Category: Consumer Health News Tags: Rheumatology News Source Type: news
RA Remission? Stop Methotrexate, Keep Etanercept RA Remission? Stop Methotrexate, Keep Etanercept
In patients with RA whose disease is well controlled by methotrexate and etanercept, withdrawal of methotrexate led to long-term outcomes that were nearly as good as continuation of combination therapy.Medscape Medical News
Source: Medscape Medical News Headlines - November 24, 2020 Category: Consumer Health News Tags: Rheumatology News Source Type: news
Gestational trophoblastic disease in Switzerland: retrospective study of the impact of a regional reference centre.
CONCLUSIONS: This study reflects the activity of the Swiss trophoblastic disease centre from the French-speaking part of Switzerland created in 2009, and its role as local and national reference centre, in terms of global health, for women with gestational trophoblastic disease.
PMID: 33578430 [PubMed - as supplied by publisher]
Source: Swiss Medical Weekly - February 1, 2021 Category: General Medicine Authors: Fehlmann A, Benkortbi K, Rosseel G, Meyer-Hamme U, Tille JC, Sloan-Bena F, Paoloni-Giacobino A, Rougemont AL, Bodmer A, Botsikas D, Mathevet P, Petignat P, Undurraga Malinverno M Tags: Swiss Med Wkly Source Type: research
Bowel perforation due to methotrexate therapeutic error: an insidious adverse reaction
CONCLUSIONS: The patient was discharged on the 17th day in good clinical condition.PMID:33755972 | DOI:10.26355/eurrev_202103_25273
Source: European Review for Medical and Pharmacological Sciences - March 23, 2021 Category: Drugs & Pharmacology Authors: M Cirronis E Novara T Persiano S Perlini C A Locatelli Source Type: research
