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Drug: Diclofenac
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Total 177 results found since Jan 2013.

Molecules, Vol. 27, Pages 3350: Diclofenac Ion Hydration: Experimental and Theoretical Search for Anion Pairs
Vener Self-assembly of organic ions in aqueous solutions is a hot topic at the present time, and substances that are well-soluble in water are usually studied. In this work, aqueous solutions of sodium diclofenac are investigated, which, like most medicinal compounds, is poorly soluble in water. Classical MD modeling of an aqueous solution of diclofenac sodium showed equilibrium between the hydrated anion and the hydrated dimer of the diclofenac anion. The assignment and interpretation of the bands in the UV, NIR, and IR spectra are based on DFT calculations in the discrete-continuum approximation. It has been shown...
Source: Molecules - May 23, 2022 Category: Chemistry Authors: Shishkina Ksenofontov Penkov Vener Tags: Article Source Type: research

Analgesic Effect of Zanthoxylum nitidum Extract in Inflammatory Pain Models Through Targeting of ERK and NF- κB Signaling
Conclusion: The present study suggests that the extract of LMZ attenuates CFA-induced inflammatory pain by suppressing the ERK1/2 and NF-κB signaling pathway at both peripheral and central level. Introduction Pain is one of the most common symptoms in clinical practice, and inflammatory pain is the most important type of pain (Patapoutian et al., 2009). Inflammatory pain is a growing global health problem. In generally, there is a common course of progression in inflammation and pain share. When patients experience inflammation, they may develop hyperalgesia or allodynia to various mechanical, thermal, or ch...
Source: Frontiers in Pharmacology - April 23, 2019 Category: Drugs & Pharmacology Source Type: research

Green remediation potential of immobilized oxidoreductases to treat halo-organic pollutants persist in wastewater and soil matrices - A way forward
Chemosphere. 2021 Dec 17:133305. doi: 10.1016/j.chemosphere.2021.133305. Online ahead of print.ABSTRACTThe alarming presence of hazardous halo-organic pollutants in wastewater and soils generated by industrial growth, pharmaceutical and agricultural activities is a major environmental concern that has drawn the attention of scientists. Unfortunately, the application of conventional technologies within hazardous materials remediation processes has radically failed due to their high cost and ineffectiveness. Consequently, the design of innovative and sustainable techniques to remove halo-organic contaminants from wastewater ...
Source: Chemosphere - December 20, 2021 Category: Chemistry Authors: Ashutosh Sharma Luis Alberto Bravo V ázquez Erick Octavio Mora Hern ández Mariana Yunuen Moreno Becerril Goldie Oza Shiek S S J Ahmed Sathishkumar Ramalingam Hafiz M N Iqbal Source Type: research

A review on environmental monitoring of water organic pollutants identified by EU guidelines
Publication date: 15 February 2018 Source:Journal of Hazardous Materials, Volume 344 Author(s): João C.G. Sousa, Ana R. Ribeiro, Marta O. Barbosa, M. Fernando R. Pereira, Adrián M.T. Silva The contamination of fresh water is a global concern. The huge impact of natural and anthropogenic organic substances that are constantly released into the environment, demands a better knowledge of the chemical status of Earth’s surface water. Water quality monitoring studies have been performed targeting different substances and/or classes of substances, in different regions of the world, using different types of sampling strategi...
Source: Journal of Hazardous Materials - October 14, 2017 Category: Environmental Health Source Type: research

A Symphytum officinale Root Extract Exerts Anti-inflammatory Properties by Affecting Two Distinct Steps of NF- κB Signaling
Discussion A common denominator of a broad spectrum of muscle and joint-related disorders is inflammation. Here, we utilized an in vitro model to assay the effect of a hydroalcoholic extract of comfrey root on one of the key steps in this process, namely, the IL-1 induced expression of E-selectin in endothelial cells (Smith, 1993). Two forms of IL-1, IL-1α and -β, bind to the same receptor(s) and evoke the same signaling pathway(s), however, are processed differently from their respective precursors, namely by ICE/caspase-1 and calpain, respectively. Whereas calpain is activated especially upon loss of plasm...
Source: Frontiers in Pharmacology - April 25, 2019 Category: Drugs & Pharmacology Source Type: research

Preliminary Phytochemical Analysis: In-Vitro Comparative Evaluation of Anti-arthritic and Anti-inflammatory Potential of Some Traditionally Used Medicinal Plants
Conclusion: It is concluded from the current study that extracts of colchicum, nux-vomica, and aloe-vera showed more potent effect and thus can be used as alternative options for the management of inflammatory and arthritic ailments.PMID:35069052 | PMC:PMC8753080 | DOI:10.1177/15593258211069720
Source: Dose Response - January 24, 2022 Category: Drugs & Pharmacology Authors: Sundas Farooq Ghazala Shaheen Hafiz Muhammad Asif Muhammad Rahil Aslam Rabia Zahid Sehrish R Rajpoot Sana Jabbar Farah Zafar Source Type: research

Comprehensive chemical characterization of indoor dust by target, suspect screening and nontarget analysis using LC-HRMS and GC-HRMS
Environ Pollut. 2021 Feb 8;276:116701. doi: 10.1016/j.envpol.2021.116701. Online ahead of print.ABSTRACTSince humans spend more than 90% of their time in indoor environments, indoor exposure can be an important non-dietary pathway to hazardous organic contaminants. It is thus important to characterize the chemical composition of indoor dust to assess the total contaminant exposure and estimate human health risks. The aim of this investigation was to perform a comprehensive chemical characterization of indoor dust. First, the robustness of an adopted extraction method using ultrasonication was evaluated for 85 target compou...
Source: Environmental Pollution - February 23, 2021 Category: Environmental Health Authors: Florian Dubocq Anna K ärrman Jakob Gustavsson Thanh Wang Source Type: research