A Symphytum officinale Root Extract Exerts Anti-inflammatory Properties by Affecting Two Distinct Steps of NF- κB Signaling

A Symphytum officinale Root Extract Exerts Anti-inflammatory Properties by Affecting Two Distinct Steps of NF-κB Signaling Jacqueline Seigner1, Marc Junker-Samek2, Alberto Plaza2, Gilda D‘Urso3, Milena Masullo3, Sonia Piacente3, Yvonne M. Holper-Schichl4*† and Rainer de Martin1*† 1Department of Vascular Biology, Medical University of Vienna, Vienna, Austria 2R&D, Procter &Gamble Health, Darmstadt, Germany 3Dipartimento di Farmacia, Università degli Studi di Salerno, Salerno, Italy 4Drehm Pharma GmbH, Vienna, Austria Symphytum officinale, commonly known as comfrey, constitutes a traditional medicinal plant with a long-standing therapeutic history, and preparations thereof have been widely used for the treatment of painful muscle and joint complaints, wound and bone healing, and inflammation. Today, its topical use is based on its analgesic and anti-inflammatory effects, which have been substantiated by modern clinical trials. However, the molecular basis of its action remained elusive. Here, we show that a hydroalcoholic extract of comfrey root impairs the development of a pro-inflammatory scenario in primary human endothelial cells in a dose-dependent manner. The extract, and especially its mucilage-depleted fraction, impair the interleukin-1 (IL-1) induced expression of pro-inflammatory markers including E-selectin, VCAM1, ICAM1, and COX-2. Both preparations inhibit the activation of NF-κB, a transcription factor of cent...
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research

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CONCLUSION: The small amount of evidence that is currently available suggests that presbycusis is underdiagnosed and under- treated in Germany. Early detection by physicians of all specialties, followed in each case by a specialized differential diagnostic evaluation, is a desirable goal. PMID: 31196393 [PubMed - in process]
Source: Deutsches Arzteblatt International - Category: General Medicine Tags: Dtsch Arztebl Int Source Type: research
CONCLUSION: The causes of visual impairment are manifold. Loss of vision is often the combined effect of multiple pathological factors. The etiology of visual impair- ment is thus a more complex matter than is commonly assumed. PMID: 31196384 [PubMed - in process]
Source: Deutsches Arzteblatt International - Category: General Medicine Tags: Dtsch Arztebl Int Source Type: research
The recall is only for Lot B16119A. No other products are affected. Lifestyle Evolution is voluntarily recalling one shift of NuGo Slim Crunchy Peanut Butter nutrition bars. In isolated cases, a product with milk allergen was incorrectly packaged into Slim Crunchy Peanut Butter wrappers and cartons. The NuGo Slim Crunchy Peanut Butter wrapper does not list milk as an allergen.
Source: FDA Food Alergies - Category: Food Science Authors: Source Type: alerts
CONCLUSION: These findings indicate increased resistance of E. coli to ciprofloxacin in comparison with prior studies. Further research in this field will increase our knowledge and more effective exposure to the antibiotic resistance of the pathogenic microorganisms. PMID: 31198116 [PubMed - as supplied by publisher]
Source: Recent Patents on Anti-Infective Drug Discovery - Category: Infectious Diseases Tags: Recent Pat Antiinfect Drug Discov Source Type: research
The objective of the study was to investigate the antidiabetic and antioxidant effects of Foeniculum vulgare in streptozotocin-induced diabetic rat. METHODS: The effects of the leaves aqueous extract (LAE) of Foeniculum vulgare (F. vulgare) at a dose of 10 mg/kg on blood glucose levels were evaluated in normal and streptozotocin (STZ)-induced diabetic rats. Histopathological changes were also evaluated in liver in STZ-induced rats. RESULTS: Single oral administration of F. vulgare LAE reduced blood glucose levels 6 h after administration in STZ diabetic rats (p
Source: Cardiovascular and Hematological Disorders Drug Targets - Category: Drugs & Pharmacology Tags: Cardiovasc Hematol Disord Drug Targets Source Type: research
CONCLUSION: The campaign did not change overall possession rate, but respondents who were familiar with the campaign were more likely to possess such a list.
. PMID: 31198166 [PubMed - as supplied by publisher]
Source: International Journal of Clinical Pharmacology and Therapeutics - Category: Drugs & Pharmacology Tags: Int J Clin Pharmacol Ther Source Type: research
Org. Biomol. Chem., 2019, Accepted Manuscript DOI: 10.1039/C9OB00754G, CommunicationYing Wei, Mengcheng Luo, Guang-Wei Zhang, Jia-Qi Lei, Linghai Xie, Wei Huang The synthesis of fluorene-based 3D-Grid-FTPA has been developed by the one-pot formation of six C(sp2)-C(sp3) bonds through BF3 •Et2O-mediated Friedel-Crafts reaction of A2-type DFOH and two B3-type triphenylamines with a total... The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Organic and Biomolecular Chemistry - Category: Molecular Biology Authors: Source Type: research
Authors: Pileri A, Gunnella S, Grandi V, Maio V, Santucci M, Pimpinelli N, Lymphoma Italian Foundation (Fondazione Italiana Linfomi, FIL) - Cutaneous Lymphoma Task Force (Commissione Linfomi Cutanei) PMID: 31195783 [PubMed - as supplied by publisher]
Source: Giornale Italiano di Dermatologia e Venereologia - Category: Dermatology Tags: G Ital Dermatol Venereol Source Type: research
CONCLUSIONS: During antihypertensive treatment, several dermatological reactions may occur. Clinicians should inform their patients of the increased risk of cutaneous lesions associated with the use of these drugs, and perform periodic examination of the skin. PMID: 31195782 [PubMed - as supplied by publisher]
Source: Giornale Italiano di Dermatologia e Venereologia - Category: Dermatology Tags: G Ital Dermatol Venereol Source Type: research
CONCLUSIONS: Our intervention was effective, by significantly improving the participants' knowledge and by inducing significant behavioral changes. Improving the formulation of alcoholic hand rubs may be a key factor to encourage their use. Coexisting non-occupational risk behaviors are just as important in the prevention of CHE. PMID: 31195780 [PubMed - as supplied by publisher]
Source: Giornale Italiano di Dermatologia e Venereologia - Category: Dermatology Tags: G Ital Dermatol Venereol Source Type: research
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