Analgesic Effect of Zanthoxylum nitidum Extract in Inflammatory Pain Models Through Targeting of ERK and NF- κB Signaling

Conclusion: The present study suggests that the extract of LMZ attenuates CFA-induced inflammatory pain by suppressing the ERK1/2 and NF-κB signaling pathway at both peripheral and central level. Introduction Pain is one of the most common symptoms in clinical practice, and inflammatory pain is the most important type of pain (Patapoutian et al., 2009). Inflammatory pain is a growing global health problem. In generally, there is a common course of progression in inflammation and pain share. When patients experience inflammation, they may develop hyperalgesia or allodynia to various mechanical, thermal, or chemical stimuli (Sommer et al., 2001; Fongang et al., 2017). Inflammatory pain belongs to the category of chronic pain, which is a persistent pain state caused by peripheral tissue damage mediated by a variety of factors (including trauma, bacterial, viral infection and surgery, etc.,) and is one of the most common types of clinical pain (Milligan et al., 2005). Inflammatory pain diseases often occur simultaneously with other diseases (trauma, rheumatoid arthritis, osteoarthritis, etc.) and show complex paralgesia and hyperalgesia. CFA is often used in the induction of various chronic inflammatory pain models. The study of peripheral and central mechanisms of inflammatory pain has been focused by the international research (Xu et al., 2010; Atzeni et al., 2018; Rosas et al., 2018). Numerous studies have shown that many peripheral and central nervous structures...
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research

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Source: Pan American Journal of Public Health - Category: International Medicine & Public Health Tags: Rev Panam Salud Publica Source Type: research
Authors: Sola A, Rodríguez S, Cardetti M, Dávila C Abstract Objective: To evaluate and report the clinical characteristics and outcomes of SARS-CoV-2 infection in pregnant women and newborns in Latin America. Methods: Descriptive study based on the prospective report of the units of the Ibero-American Society of Neonatology Network. Results: Of 86 pregnant women with COVID-19 confirmed by RT-PCR in seven countries (6 from Latin America, and Equatorial Guinea) 68% (59) were asymptomatic. Of 32% of symptomatic women, 89% (24) had mild symptoms and 3.5% (3) had severe respiratory symptoms. No wom...
Source: Pan American Journal of Public Health - Category: International Medicine & Public Health Tags: Rev Panam Salud Publica Source Type: research
In this study, we found only minor ethnic differences in persistent pain. Similar living conditions and cultural features may explain these findings. PMID: 32780007 [PubMed - in process]
Source: International Journal of Circumpolar Health - Category: International Medicine & Public Health Tags: Int J Circumpolar Health Source Type: research
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