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Tangshen Formula Alleviates Hepatic Steatosis by Inducing Autophagy Through the AMPK/SIRT1 Pathway
Conclusion In conclusion, the present study demonstrated that autophagy was involved in relieving the effects of TSF against NAFLD, which were mediated by the AMPK/SIRT1 pathway (Figure 7D). These findings may improve our current understanding of the role of TSF in treating hepatic steatosis and provide an experimental basis for the clinical application of TSF in NAFLD and its related metabolic syndrome. Ethics Statement This study was carried out in accordance with the recommendations in the Guide for the Care and Use of Laboratory Animals of the National Institutes of Health. The protocol was approved by the Ethics Co...
Source: Frontiers in Physiology - April 25, 2019 Category: Physiology Source Type: research

Tripterygium glycoside protects diabetic kidney disease mouse serum-induced podocyte injury by upregulating autophagy and downregulating β-arrestin-1.
CONCLUSIONS: This study demonstrated that tripterygium glycoside provided protection against podocyte injury induced by high-glucose serum, and that this effect was mediated by the concomitant activation of autophagy and downregulation of β-arrestin-1. PMID: 30839094 [PubMed - as supplied by publisher]
Source: Histology and Histopathology - March 7, 2019 Category: Cytology Tags: Histol Histopathol Source Type: research

Oxymatrine attenuates oxidized low ‑density lipoprotein‑induced HUVEC injury by inhibiting NLRP3 inflammasome‑mediated pyroptosis via the activation of the SIRT1/Nrf2 signaling pathway
Int J Mol Med. 2021 Oct;48(4):187. doi: 10.3892/ijmm.2021.5020. Epub 2021 Aug 9.ABSTRACTOxymatrine, a quinolizidine alkaloid isolated from the traditional Chinese herb Sophora flavescens Aiton, has been demonstrated to exert anti‑inflammatory and atherosclerotic effects, but the molecular mechanism has yet to be elucidated. Accumulating evidence indicates an important role of NLR family pyrin domain containing 3 (NLRP3) inflammasome‑mediated pyroptosis in the pathogenesis of atherosclerosis. The present study was undertaken to investigate whether oxymatrine attenuates oxidized low‑density lipoprotein (ox‑LDL)‑ind...
Source: International Journal of Molecular Medicine - August 9, 2021 Category: Molecular Biology Authors: Xin Jin Wan Fu Jiaxiu Zhou Niannian Shuai Yan Yang Bo Wang Source Type: research

Auriculasin enhances ROS generation to regulate colorectal cancer cell apoptosis, ferroptosis, oxeiptosis, invasion and colony formation
Biochem Biophys Res Commun. 2021 Dec 1;587:99-106. doi: 10.1016/j.bbrc.2021.11.101. Online ahead of print.ABSTRACTColorectal cancer (CRC) is one of the most common malignant tumors in the digestive system, and Chinese herbal medicine plays an important role in tumor treatment. The in-depth study of auriculasin isolated from Flemingia philippinensis showed that auriculasin promoted reactive oxygen species (ROS) generation in a concentration-dependent manner; when ROS scavenger NAC was added, the effects of auriculasin in promoting ROS generation and inhibiting cell viability were blocked. Auriculasin induced CRC cell apopto...
Source: Biochemical and Biophysical Research communications - December 6, 2021 Category: Biochemistry Authors: Chun-Xiao Wang Li-Hua Chen Hai-Bin Zhuang Ze-Sheng Shi Zhi Chuan Chen Jian-Peng Pan Zhong-Shi Hong Source Type: research

Baicalin, a Chinese Herbal Medicine, Inhibits the Proliferation and Migration of Human Non-Small Cell Lung Carcinoma (NSCLC) Cells, A549 and H1299, by Activating the SIRT1/AMPK Signaling Pathway.
CONCLUSIONS Baicalin, a flavonoid used in Chinese herbal medicine, inhibited the proliferation and migration of human NSCLC cells, A549 and H1299, by activating the SIRT1/AMPK signaling pathway. PMID: 29632297 [PubMed - in process]
Source: Medical Science Monitor - April 13, 2018 Category: Research Tags: Med Sci Monit Source Type: research

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