Filtered By:
Condition: Disability
Therapy: Thrombolytic Therapy

This page shows you your search results in order of relevance. This is page number 12.

Order by Relevance | Date

Total 183 results found since Jan 2013.

The protective mechanisms of polydatin in cerebral ischemia.
Abstract The prevalence of stroke is high in both developing and developed nations. It causes a heavy social and financial burden to the sufferers and their caregivers. Thrombolytic therapy is the only pharmacological treatment available for stroke. However, thrombolytic agents do not provide substantial improvement on long term motor and cognitive disabilities. Thus, there is a need to explore for new compounds that can halt or reverse the deterioration of neurons in the stroke patients' brain. Polydatin, a precursor of resveratrol, is a natural stilbene commonly found in food. This review article describes how d...
Source: European Journal of Pharmacology - October 29, 2018 Category: Drugs & Pharmacology Authors: Tang KS, Tan JS Tags: Eur J Pharmacol Source Type: research

Single nucleotide variations in ZBTB46 are associated with post-thrombolytic parenchymal haematoma
In conclusion, we identified single nucleotide variants in theZBTB46 gene associated with a higher risk of parenchymal haematoma following recombinant tissue-plasminogen activator treatment.
Source: Brain - March 16, 2021 Category: Neurology Source Type: research

Outcomes and risk factors of perforating and non-perforating middle cerebral artery infarctions after intravenous thrombolysis
AbstractThe clinical symptoms of perforating arteries differ, and responses to intravenous thrombolytic therapy are heterogeneous. Here, we investigated the effect of intravenous thrombolytic therapy and the related factors influencing acute perforating and non-perforating middle cerebral artery infarctions. We analyzed 320 patients with acute middle cerebral artery infarction who received alteplase thrombolysis within 4.5  h of onset at two stroke centers from January 2016 to December 2019. Outcome measures included rates of a favorable functional outcome (modified Rankin Scale scores of 0–2), distribution of modified ...
Source: Journal of Thrombosis and Thrombolysis - January 14, 2022 Category: Hematology Source Type: research

Ameliorating effects of traditional Chinese medicine preparation, Chinese materia medica and active compounds on ischemia/reperfusion-induced cerebral microcirculatory disturbances and neuron damage
Publication date: January 2015 Source:Acta Pharmaceutica Sinica B, Volume 5, Issue 1 Author(s): Kai Sun , Jingyu Fan , Jingyan Han Ischemic stroke and ischemia/reperfusion (I/R) injury induced by thrombolytic therapy are conditions with high mortality and serious long-term physical and cognitive disabilities. They have a major impact on global public health. These disorders are associated with multiple insults to the cerebral microcirculation, including reactive oxygen species (ROS) overproduction, leukocyte adhesion and infiltration, brain blood barrier (BBB) disruption, and capillary hypoperfusion, ultimately resulting...
Source: Acta Pharmaceutica Sinica B - January 25, 2015 Category: Cancer & Oncology Source Type: research

Synthesis and Evaluation of a Novel Nanoparticle Carrying Urokinase Used in Targeted Thrombolysis.
This article is protected by copyright. All rights reserved. PMID: 31581363 [PubMed - as supplied by publisher]
Source: Biomed Res - October 2, 2019 Category: Research Authors: Zhong Y, Gong WJ, Gao XH, Li YN, Liu K, Hu YG, Qi JS Tags: J Biomed Mater Res A Source Type: research

Dysphagia and disability in minor strokes – An institutional study
Ischemic strokes can be mild and non-disabling in around two third patients at onset.1 This is one of the major reason for delay in seeking medical attention, non-administration of thrombolytic therapy, incomplete evaluation and non-urgent initiation of secondary preventive strategies. Risk of early recurrence of neurological events is around 12%, with roughly half of them occurring in the first 48  h of onset.2 These strokes are not always associated with excellent outcome with short term disability ranging between 19% and 35% across various studies.
Source: Journal of Stroke and Cerebrovascular Diseases - August 15, 2020 Category: Neurology Authors: Sapna Erat Sreedharan, Jaffar Vali Sayed, V P Vipina, Manju P Mohan, Rejith Paul, PN Sylaja Source Type: research

Stent retriever thrombectomy combined with long-term local thrombolysis for severe hemorrhagic cerebral venous sinus thrombosis.
Authors: Wang Y, Zhao C, Huang D, Sun B, Wang Z Abstract Cerebral venous sinus thrombosis (CVST) is a rare disease associated with high disability and mortality rates. A subset of patients do not respond to standard anticoagulation therapy, leading to the progression of CVST with hemorrhagic stroke, which represents a major challenge for its treatment. Severe hemorrhagic (SH)-CVST is life-threatening due to large hematoma, edema and/or cerebral hernia. Anticoagulation or thrombolytic therapy alone may lead to further aggravation of the hematoma. Stent retriever thrombectomy combined with long-term local thrombolysi...
Source: Experimental and Therapeutic Medicine - September 24, 2020 Category: General Medicine Tags: Exp Ther Med Source Type: research

Delayed administration of thrombolytic therapy in minor stroke
CONCLUSIONS: The presence of few symptoms in minor strokes can make them difficult to recognise and could be a reason for delaying treatment. Training among staff caring for these patients is essential to improve this aspect.PMID:33978229 | DOI:10.33588/rn.7210.2020510
Source: Revista de Neurologia - May 12, 2021 Category: Neurology Authors: S P érez-Sánchez A Barrag án-Prieto J A S ánchez-Miura A Dom ínguez-Mayoral R de Torres-Chac ón M A Gamero-Garc ía J L G álvez-San Román J Herrero-Lara M Garrido-Castilla L Cueto C Navarro-Bustos J Montaner Source Type: research