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Nutrition: Antidoxidants

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Total 71 results found since Jan 2013.

Rutin protects hemorrhagic stroke development via supressing oxidative stress and inflammatory events in a zebrafish model
Eur J Pharmacol. 2022 Apr 22:174973. doi: 10.1016/j.ejphar.2022.174973. Online ahead of print.ABSTRACTIntracerebral haemorrhagic (ICH) stroke is a major cause of death and disability globally, with no proper treatment available so far. Rutin, a dietary flavonoid, has shown protection against cerebral ischemic stroke due to its antioxidant and anti-inflammatory attributes. However, the efficacy of rutin against ICH stroke remained unexplored. Therefore, in the current study, we investigated the effect of rutin in an ICH stroke zebrafish larva model. The larvae were exposed to atorvastatin (1.25 μM) in system water for indu...
Source: European Journal of Pharmacology - April 26, 2022 Category: Drugs & Pharmacology Authors: Anil Kumar Rana Supriya Sharma Shiv Kumar Saini Damanpreet Singh Source Type: research

Mitigated Oxidative Stress and Cognitive Impairments in Transient Global Ischemia using Niosomal Selegiline-NBP delivery
Behav Neurol. 2022 Apr 16;2022:4825472. doi: 10.1155/2022/4825472. eCollection 2022.ABSTRACTStroke is the most common reason for adult disabilities and the second ground for death worldwide. Our previous study revealed that selegiline serves as an alternative candidate in transient hypoxia-ischemia. However, aggressive and restless behavior was observed in stroke-induced rats receiving 4 mg/kg selegiline. In comparison, 1 mg/kg selegiline could induce negligible therapeutic effects on mitochondrial dysfunction and histopathological changes. Therefore, we designed oral noisome-based selegiline attached to 4-(4-nitrobenzyl) ...
Source: Behavioural Neurology - April 26, 2022 Category: Neurology Authors: Bahareh Jafari Mahmoud Gharbavi Yasamin Baghdadchi Hamidreza Kheiri Manjili Javad Mahmoudi Iraj Jafari-Anarkoli Shayan Amiri Mir-Jamal Hosseini Source Type: research

Brain Targeting, Antioxidant Polymeric Nanoparticles for Stroke Drug Delivery and Therapy
This study develops nanoparticles (NPs) consisting of a reactive oxygen species (ROS)-reactive polymer and further engineers them for targeted drug delivery to the ischemic brain through ligand-mediated interaction and thrombin-triggered shrinkability. It is demonstrated that the resulting NPs can efficiently deliver glyburide to the brain for effective stroke treatment. AbstractIschemic stroke is a leading cause of death and disability and remains without effective treatment options. Improved treatment of stroke requires efficient delivery of multimodal therapy to ischemic brain tissue with high specificity. Here, this ar...
Source: Small - March 20, 2022 Category: Nanotechnology Authors: Haoan Wu, Bin Peng, Farrah S. Mohammed, Xingchun Gao, Zhenpeng Qin, Kevin N. Sheth, Jiangbing Zhou, Zhaozhong Jiang Tags: Research Article Source Type: research

Alamandine Induces Neuroprotection in Ischemic Stroke Models
CONCLUSION: This study showed, for the first time, a neuroprotective role for Alamandine in different ischemic stroke models.PMID:35125076 | DOI:10.2174/0929867329666220204145730
Source: Current Medicinal Chemistry - February 7, 2022 Category: Chemistry Authors: Sth éfanie C A Gonçalves Beatriz L T Bassi Lucas M Kangussu Daniele T Alves Lorena K S Ramos Lorena F Fernandes Marco T R Alves Ruben Sinisterra Gisele E Bruch Robson A S Santos Andr é R Massensini Maria Jos é Campagnole-Santos Source Type: research

Novel mechanistic insight on the neuroprotective effect of berberine: The role of PPAR δ for antioxidant action
Free Radic Biol Med. 2022 Jan 27:S0891-5849(22)00033-8. doi: 10.1016/j.freeradbiomed.2022.01.022. Online ahead of print.ABSTRACTCerebral ischemic stroke ranks the second leading cause of death and the third leading cause of disability in lifetime all around the world, urgently necessitating effective therapeutic interventions. Reactive oxygen species (ROS) have been implicated in stroke pathogenesis and peroxisome proliferator-activated receptors (PPARs) are prominent targets for ROS management. Although recent research has shown antioxidant effect of berberine (BBR), little is known regarding its effect upon ROS-PPARs sig...
Source: Free Radical Biology and Medicine - January 30, 2022 Category: Biology Authors: Jia-Wen Shou Xiao-Xiao Li Yun-Sang Tang Bobby Lim-Ho Kong Hoi-Yan Wu Meng-Jie Xiao Chun-Kai Cheung Pang-Chui Shaw Source Type: research

Neuroinflammatory Triangle Presenting Novel Pharmacological Targets for Ischemic Brain Injury
Ischemic stroke is one of the leading causes of morbidity and mortality globally. Hundreds of clinical trials have proven ineffective in bringing forth a definitive and effective treatment for ischemic stroke, except a myopic class of thrombolytic drugs. That, too, has little to do with treating long-term post-stroke disabilities. These studies proposed diverse options to treat stroke, ranging from neurotropic interpolation to venting antioxidant activity, from blocking specific receptors to obstructing functional capacity of ion channels, and more recently the utilization of neuroprotective substances. However, state of t...
Source: Frontiers in Immunology - October 7, 2021 Category: Allergy & Immunology Source Type: research

Molecules, Vol. 26, Pages 5985: The Neuroprotective Role of Polydatin: Neuropharmacological Mechanisms, Molecular Targets, Therapeutic Potentials, and Clinical Perspective
-Sánchez Neurodegenerative diseases (NDDs) are one of the leading causes of death and disability in humans. From a mechanistic perspective, the complexity of pathophysiological mechanisms contributes to NDDs. Therefore, there is an urgency to provide novel multi-target agents towards the simultaneous modulation of dysregulated pathways against NDDs. Besides, their lack of effectiveness and associated side effects have contributed to the lack of conventional therapies as suitable therapeutic agents. Prevailing reports have introduced plant secondary metabolites as promising multi-target agents in combating NDDs. Polyda...
Source: Molecules - October 2, 2021 Category: Chemistry Authors: Sajad Fakhri Mohammad Mehdi Gravandi Sadaf Abdian Esra K üpeli Akkol Mohammad Hosein Farzaei Eduardo Sobarzo-S ánchez Tags: Review Source Type: research

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