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Condition: Pregnancy
Infectious Disease: Group B Streptococcus

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Total 23 results found since Jan 2013.

Antibiotic choice for Group B Streptococcus prophylaxis in mothers with reported penicillin allergy and associated newborn outcomes
To evaluate the choice of antibiotic used for intrapartum Group B Streptococcus (GBS) prophylaxis in pregnant individuals with reported penicillin allergies compared to those without reported penicillin allerg...
Source: BMC Pregnancy and Childbirth - May 30, 2023 Category: OBGYN Authors: Josephine B. Snider, Leena B. Mithal, Jason H. Kwah, Nathaniel J. Rhodes and Moeun Son Tags: Research Source Type: research

Group B Streptococcus in Pregnancy
To decrease risk of early-onset neonatal sepsis from group B streptococcus (GBS), pregnant patients should undergo screening between 36 0/7 and 37 6/7 weeks ’ gestation. Patients with a positive vaginal-rectal culture, GBS bacteriuria , or history of newborn with GBS disease should receive intrapartum antibiotic prophylaxis (IAP) with an agent targeting GBS. If GBS status is unknown at time of labor, IAP should be administered in cases of preterm birt h, rupture of membranes for>18 hours, or intrapartum fever. The antibiotic of choice is intravenous penicillin; alternatives should be considered in cases of penicillin all...
Source: Obstetrics and Gynecology Clinics - April 2, 2023 Category: OBGYN Authors: Jenny Y. Mei, Neil S. Silverman Source Type: research

Maternal Penicillin Allergy and Infant Outcomes: Results from a Large, Administrative Cohort
We examined the outcomes of infants born to GBS-positive mothers with and without a reported penicillin allergy.
Source: Journal of Allergy and Clinical Immunology - February 1, 2023 Category: Allergy & Immunology Authors: Laura Ann Wang, Rebecca Baer, Jennifer Namazy, Christina Chambers Source Type: research

Maternal Origins of Neonatal Infections: What Do Obstetrician –Gynecologist Should/Could Do?
In conclusion, obstetricians should be aware that the treatment of maternal infection during pregnancy can prevent potentially lethal infections in the newborn. Key Points [...] Thieme Medical Publishers, Inc. 333 Seventh Avenue, 18th Floor, New York, NY 10001, USAArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text
Source: American Journal of Perinatology - December 19, 2022 Category: Perinatology & Neonatology Authors: Germano, Chiara Messina, Alessandro Massaro, Alessio Attini, Rossella Leo, Livio Manzoni, Paolo Masturzo, Bianca Tags: Review Article Source Type: research

Implementing a referral protocol for penicillin allergy testing of pregnant women
Recent American College of Obstetrics and Gynecology (ACOG) guidelines advocate for the safety of penicillin allergy testing in pregnant women. Penicillin allergy de-labeling allows for preferred peripartum antibiotic therapy for Group B Streptococcus (GBS) prophylaxis and reduces IV antibiotics and neonatal ICU (NICU) care for newborns. Yet, there remains widespread hesitance to perform penicillin allergy testing on pregnant women.
Source: Annals of Allergy, Asthma and Immunology - November 1, 2022 Category: Allergy & Immunology Authors: M. Patel, E. Stephen, L. Laursen, S. Bandi Tags: P205 Source Type: research

Improving Intrapartum Group B Streptococcus Prophylaxis in Patients with a Reported Penicillin or Cephalosporin Allergy: A Quality Improvement Project
CONCLUSIONS: Implementation of standardized allergy-guided prophylaxis safely improved appropriate β-lactam antibiotic use in obstetric patients requiring GBS prophylaxis who reported penicillin and cephalosporin allergies.PMID:35338006 | DOI:10.1016/j.jogc.2022.02.128
Source: Journal of Obstetrics and Gynaecology Canada : JOGC - March 26, 2022 Category: OBGYN Authors: Linda X Li Cyndy Oliver Stefania Ronzoni Arthur Zaltz Jerome A Leis Marion Elligsen Philip W Lam Source Type: research

Safety and Outcomes for Penicillin Skin Testing in Pregnancy
Penicillin allergy in pregnant women is associated with increased morbidity and use of less effective antibiotics to treat group B streptococcus infections. Although the American College of Obstetrics and Gynecology recommends evaluation of women with penicillin allergy prior to delivery, testing in pregnancy remains infrequent. We studied the largest known cohort to date of pregnant women who underwent penicillin allergy evaluation to assess the effectiveness and safety of penicillin skin test and oral drug challenge in pregnancy.
Source: Journal of Allergy and Clinical Immunology - February 1, 2021 Category: Allergy & Immunology Authors: Vima Patel, Olajumoke Fadugba, Steven Ralston, Kathryn Delaney, Scott Feldman Source Type: research

Penicillin Allergy Evaluation in Pregnancy Impacts Antibiotic Utilization and Neonatal Clinical Outcomes
Penicillin (PCN) allergy is commonly reported, but many are erroneously labeled. Pregnancy is associated with high antibiotic usage, with indications including prophylaxis for surgical Caesarean section delivery and group B streptococcus (GBS) colonization, a leading cause of neonatal sepsis. PCN allergy evaluation has the potential to significantly impact both maternal and neonatal clinical outcomes, however, proactive drug allergy evaluations during pregnancy remain underutilized.
Source: Journal of Allergy and Clinical Immunology - February 1, 2021 Category: Allergy & Immunology Authors: Jamie Waldron, Nerlyne Desravines, Kim Boggess, Mildred Kwan Source Type: research

The impact of maternal penicillin allergy on neonatal care and health care cost
Less effective antibiotics are often administered to pregnant women with reported penicillin allergy and group B streptococcus (GBS) colonization, which results in additional testing and increased observation time of the neonatal population. We suspect that healthcare costs and length of stay is thereby increased in neonates of mothers who report penicillin allergy.
Source: Journal of Allergy and Clinical Immunology - January 31, 2020 Category: Allergy & Immunology Authors: Dustin Fowler, Susan Evenhouse, Corinne Corrigan, Claire MacGeorge, Annie Andrews, Genevieve Hayes, Kelli Williams Source Type: research

Implementation of Proactive Penicillin Allergy Evaluation in Pregnancy
Penicillin (PCN) allergy is commonly reported, but many are erroneously labeled. Pregnant women reporting PCN allergy receive suboptimal antibiotic alternatives for group B streptococcus (GBS) infection, a leading cause of neonatal sepsis, increasing bacterial resistance and maternal and neonatal morbidity. Protocols implementing PCN evaluation during the prenatal period remain underutilized.
Source: Journal of Allergy and Clinical Immunology - January 31, 2020 Category: Allergy & Immunology Authors: Jamie Waldron, Nerlyne Desravines, Mildred Kwan, Scott Commins, Kim Boggess Source Type: research

The Penicillin Allergy Label and Pregnancy-Related Outcomes
There is limited data on the effect of the penicillin allergy label (PAL) in pregnancy-related outcomes, including among Group B Streptococcus (GBS)-positive women.
Source: Journal of Allergy and Clinical Immunology - January 31, 2020 Category: Allergy & Immunology Authors: Allison Ramsey, Kwame Okrah, Shahzad Mustafa, Mary Staicu Source Type: research

Prophylaxis Against Early-onset Group B Streptococcus Infections in Pregnant Women Who Are Allergic to Penicillin
This article will review established screening techniques, intrapartum antibiotic prophylactic regimens, and management specifically of the penicillin-allergic pregnant woman who is colonized with GBS.
Source: Clinical Obstetrics and Gynecology - October 23, 2019 Category: OBGYN Tags: New Antibiotics and Antibiotic Prophylaxis in Obstetrics Source Type: research

Intrapartum Group B Streptococcus Antibiotic Prophylaxis in Penicillin Allergic Pregnant Women
Conclusion Alternative antibiotic use for GBS prophylaxis is frequent with penicillin/cephalosporin allergies. Efforts to confirm allergy and perform penicillin hypersensitivity testing may increase compliance with guidelines for antibiotic administration. [...] Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.Article in Thieme eJournals: Table of contents  |  Abstract  |  open access Full text
Source: American Journal of Perinatology Reports - July 29, 2019 Category: Perinatology & Neonatology Authors: Desravines, Nerlyne Venkatesh, Kartik K. Hopkins, Austin Waldron, Jamie Grant, Megan McGuire, Colleen Boggess, Kim A. Tags: Original Article Source Type: research

Mast cell chymase decreases the severity of group B Streptococcus infections
Group B Streptococcus (GBS) or Streptococcus agalactiae are β-hemolytic gram-positive bacteria that colonize the lower genital tracts of women and are frequently associated with infections during pregnancy. Innate immune defenses are critical for controlling GBS dissemination and systemic infection. Mast cells are resident sentinel cells that come into cont act with pathogens early during colonization and infection.
Source: Journal of Allergy and Clinical Immunology - September 12, 2017 Category: Allergy & Immunology Authors: Claire Gendrin, Nicholas J. Shubin, Erica Boldenow, Sean Merillat, Morgan Clauson, Danial Power, Kelly S. Doran, Magnus Abrink, Gunnar Pejler, Lakshmi Rajagopal, Adrian M. Piliponsky Source Type: research