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Warfarin for stroke prevention in hemodialysis patients with non-valvular atrial fibrillation.
PMID: 26882633 [PubMed - in process]
Source: CANNT Journal - July 1, 2015 Category: Urology & Nephrology Authors: Badr S, Cameron K, Battistella M Tags: CANNT J Source Type: research

Warfarin Use and the Risk of Mortality, Stroke, and Bleeding in Hemodialysis Patients with Atrial Fibrillation
The optimal management of stroke prophylaxis in hemodialysis patients with atrial fibrillation is controversial.
Source: Heart Rhythm - February 5, 2017 Category: Cardiology Authors: Brandon Kai, Yuliya Bogorad, Leigh-Ann N. Nguyen, Su-Jau Yang, Wansu Chen, Hillard T. Spencer, Albert Y.-J. Shen, Ming-Sum Lee Source Type: research

Does renal function have incremental predictive value of stroke in atrial fibrillation?
It is well known that both atrial fibrillation (AF) and chronic kidney disease (CKD) are respectively independent predictors of stroke and systemic thromboembolism. A number of epidemiological and observational studies have shown that there are close relationships between AF and CKD [1 –3]. Indeed, the prevalence of AF increases from non-CKD to CKD stages of 1 to 2, 3 and 4 to 5 by 1.0%, 2.8%, 2.7%, and 4.2%, respectively [1], and the prevalence is 7% to 27% in patients with end-stage renal disease who are undergoing hemodialysis therapy [2].
Source: International Journal of Cardiology - August 28, 2018 Category: Cardiology Authors: Yukihito Higashi Tags: Editorial Source Type: research

Relation of Race, Apparent Disability, and Stroke Risk With Warfarin Prescribing for Atrial Fibrillation in Patients Receiving Maintenance Hemodialysis
We examined patterns of warfarin use, and associated factors, after AF diagnosis. This retrospective cohort analysis studied US Medicare patients receiving maintenance dialysis January 1, 2008-June 30, 2010. Demographics, comorbidity, and a durable medical equipment claims-based disability proxy score predicted warfarin prescription after AF diagnosis. The analysis included 8964 patients with non-valvular AF.
Source: The American Journal of Cardiology - November 24, 2018 Category: Cardiology Authors: James B. Wetmore, Yi Peng, David T. Gilbertson, Jiannong Liu Source Type: research

Racial/Ethnic Disparity Seen for Stroke in Dialysis Patients With A-Fib
MONDAY, Feb. 24, 2020 -- Among hemodialysis patients with atrial fibrillation, racial/ethnic disparities in all-cause stroke are partially mediated by lower anticoagulant use, according to a study published online Feb. 20 in the Journal of the...
Source: Drugs.com - Pharma News - February 24, 2020 Category: Pharmaceuticals Source Type: news

Apixaban for stroke prevention in hemodialysis patients with non-valvular atrial fibrillation
Atrial fibrillation (AF) is a common arrhythmia among patients with kidney failure on maintenance hemodialysis (HD) and is associated with a high incidence of all-cause mortality and stroke in this population.1
Source: Kidney International - April 11, 2023 Category: Urology & Nephrology Authors: Thomas A. Mavrakanas Tags: nephrology digest Source Type: research

Apixaban for stroke prevention in hemodialysis patients with nonvalvular atrial fibrillation
Atrial fibrillation (AF) is a common arrhythmia among patients with kidney failure on maintenance hemodialysis (HD) and is associated with a high incidence of all-cause mortality and stroke in this population.1
Source: Kidney International - April 11, 2023 Category: Urology & Nephrology Authors: Thomas A. Mavrakanas Tags: Nephrology Digest Source Type: research

Can I use DOAC in a patient with renal disease?
Case A 76-year-old man is diagnosed with non-valvular atrial fibrillation. His comorbid conditions are hypertension, diabetes complicated by neuropathy, and chronic kidney disease stage 3. His current medications include metformin, lisinopril, gabapentin, and aspirin. His most recent laboratories showed a creatinine 1.8, creatinine clearance (CrCl) 35 mL/min, hemoglobin 11g/dL, and international normalized ratio 1.0. His congestive heart failure, hypertension, age, diabetes, stroke, vascular disease, and sex (CHADSVASc) score is 4. Which medication should we use to prevent stroke in this patient?  Brief overview of the is...
Source: The Hospitalist - February 3, 2022 Category: Hospital Management Authors: Ronda Whitaker Tags: Renal & Genitourinary Source Type: research

Racial Differences and Outcomes of Strokes in Patients on Hemodialysis: A 10-Year Retrospective Study (P1.081)
CONCLUSIONS: AIS was a common complication in HD patients affecting LOS as well as mortality. African Americans patients were younger compared to Caucasians, who had higher incidence of atrial fibrillation. Overall mortality was high and infections were an independent predictor of mortality in HD patients with stroke. Study Supported by: NoneDisclosure: Dr. Sunbulli has nothing to disclose. Dr. Dhakar has nothing to disclose. Dr. Rajamani has nothing to disclose.
Source: Neurology - April 8, 2015 Category: Neurology Authors: Sunbulli, M., Dhakar, M., Rajamani, K. Tags: Neuroepidemiology: Cerebrovascular Disease Source Type: research

Cardiologists' and nephrologists' management of atrial fibrillation in hemodialysis patients 
.
CONCLUSION: Cardiologists were more likely to prescribe anticoagulant therapy for AF in the HD population compared to nephrologists, regardless of patient stroke or bleeding risk.
. PMID: 31496513 [PubMed - as supplied by publisher]
Source: Clinical Nephrology - September 8, 2019 Category: Urology & Nephrology Authors: Marcus L, Mackeigan L, Leblanc K, Orlov D, Mitsakakis N, Austin Z, Jassal SV, Battistella M Tags: Clin Nephrol Source Type: research

Left Atrial Appendage Closure During Coronary Bypass Surgery in Patients on Hemodialysis
CONCLUSIONS: Concomitant LAA closure during CABG can reduce the risk of death and stroke in ESRD-HD patients with normal sinus rhythm.PMID:36928272 | DOI:10.1253/circj.CJ-22-0573
Source: Circulation Journal - March 17, 2023 Category: Cardiology Authors: Daisuke Endo Takeshi Kinoshita Jiyoung Lee Yoichiro Machida Kosuke Nishida Yuichiro Sato Taira Yamamoto Minoru Tabata Source Type: research

Efficacy and safety of direct oral anticoagulants vs vitamin K antagonists in patients with atrial fibrillation and end-stage renal disease on hemodialysis: A systematic review and meta-analysis
CONCLUSIONS: Among AF patients with ESRD on chronic hemodialysis, the risk of ischemic stroke, ischemic stroke or systemic embolism, minor bleeding, major bleeding, and all-cause mortality is similar in patients treated with DOACs compared to VKAs. Given that the meta-analysis of RCTs on gastrointestinal bleeding did not confirm the results of the meta-analysis of the observational studies, it cannot be concluded that gastrointestinal bleeding is lower among DOAC-treated patients.PROTOCOL REGISTRATION: PROSPERO CRD42023391966.PMID:37648582 | DOI:10.1016/j.ejim.2023.08.020
Source: European Journal of Internal Medicine - August 30, 2023 Category: Internal Medicine Authors: Ioannis Kyriakoulis Anastasia Adamou Iliana Stamatiou David Dimitris Chlorogiannis Ioannis Kardoutsos Despoina Koukousaki George Ntaios Source Type: research

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