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Specialty: Surgery
Condition: Thrombosis

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Total 198 results found since Jan 2013.

Trapped cerebral thrombectomy device: A case report of a rare complication.
Abstract Intravenous thrombolysis with recombinant tissue plasminogen activator is currently the standard therapy for acute ischaemic stroke when started within 4.5 h of symptom onset. Systemic thrombolytic therapy can, however, lead to potentially lethal bleeding complications and is contra-indicated in several circumstances. Intra-arterial thrombolysis and/or intra-arterial thrombectomy can overcome these drawbacks and even increase the rate of recanalization. While intravenous thrombolysis is a relatively non-complex treatment, intra-arterial therapy in acute ischaemic stroke patients requires a dedicated int...
Source: Vascular - May 12, 2014 Category: Surgery Authors: Geuzebroek GS, Wille J, Vries JP, Schonewille W, Vos JA Tags: Vascular Source Type: research

Subsequent arterial ischemic events in patients receiving anticoagulant therapy for venous thromboembolism
Conclusions In patients receiving anticoagulation for VTE, the mortality due to PE recurrences was lower than the mortality due to ischemic events. Most independent predictors for ischemic events were also predictors for major bleeding and for recurrent PE.
Source: Journal of Vascular Surgery: Venous and Lymphatic Disorders - May 8, 2015 Category: Surgery Source Type: research

Carotid artery disease: clinical features and management
The most common cause of ischaemic carotid territory stroke is thromboembolism from stenoses in the extracranial internal carotid artery (ICA). In the majority, embolism is preceded by an acute change in plaque morphology thereby predisposing the patient to overlying thrombus formation and embolization. The management of patients with carotid artery disease mandates risk factor modification, antiplatelet and statin therapy in everyone. There is grade A, level I evidence that recently symptomatic patients with 50–99% NASCET stenoses gain significant benefit from carotid endarterectomy (CEA), despite a small risk of perioperative stroke.
Source: Surgery (Medicine Publishing) - June 5, 2015 Category: Surgery Authors: A Ross Naylor Tags: Vascular surgery I Source Type: research

Efficacy and safety of rivaroxaban thromboprophylaxis after arthroplasty of the hip or knee: retrospective cohort study.
Conclusions Rivaroxaban is an effective and safe anticoagulant for thromboprophylaxis after hip arthroplasty or knee arthroplasty if used in a modified regimen involving enoxaparin administered in the inpatient setting followed by rivaroxaban upon hospital discharge. PMID: 27580310 [PubMed - in process]
Source: Annals of the Royal College of Surgeons of England - August 31, 2016 Category: Surgery Authors: Loganathan L, Hua A, Patel S, Gibbons C, Vizcaychipi MP Tags: Ann R Coll Surg Engl Source Type: research

Could advanced drug delivery systems be the future in cardiovascular revascularization medicine?
Abstract Acute myocardial infarction, stroke and pulmonary embolism required a prompt revascularization to restore the normal blood flow as soon as possible. Fibrinolytic treatment has gradually become both dated and underused in the treatment of acute myocardial infarction, after the wide diffusion of cathlab and percutaneous transluminal coronary angioplasty. Conversely, the use of systemic thrombolysis remained a benchmark in the treatment of both ischemic stroke and massive pulmonary embolism. In daily clinical practice, the use of thrombolytic agents is often limited by absolute and/or relative contraindicati...
Source: Vascular - December 5, 2016 Category: Surgery Authors: Zuin M, Rigatelli G, Faggian G, L'Erario R, Chinaglia M, Roncon L Tags: Vascular Source Type: research

Impact of health utility after thrombotic complications following total hip and knee arthroplasty
ConclusionObjective calculation of both the benefit and risks of anticoagulation in the post‐operative patient is significantly altered by including the effect on patient's quality of life utility value. Therapeutic anticoagulation in some common situations is probable to be of more detriment than benefit when considering health utility.
Source: ANZ Journal of Surgery - July 31, 2017 Category: Surgery Authors: Bikram Karmakar Tags: Original Article Source Type: research

Safety and Efficacy of the New Micromesh-Covered Stent CGuard in Patients Undergoing Carotid Artery Stenting: Early Experience From a Single Centre.
CONCLUSIONS: The technical and clinical outcomes of this single centre study suggest that the CGuard may be a safe and effective device for endovascular treatment of symptomatic and asymptomatic subjects, independent of aortic arch anatomy. Further larger comparative studies are needed to confirm these benefits. PMID: 29089282 [PubMed - as supplied by publisher]
Source: PubMed: Eur J Vasc Endovasc ... - October 28, 2017 Category: Surgery Authors: Casana R, Tolva V, Odero A, Malloggi C, Paolucci A, Triulzi F, Silani V Tags: Eur J Vasc Endovasc Surg Source Type: research

Carotid artery disease: clinical features and management
The most common single cause of ischaemic carotid territory stroke is thromboembolism from stenoses in the extracranial internal carotid artery (ICA). In the majority, embolism is preceded by an acute change in plaque morphology predisposing the patient to overlying thrombus formation and embolization. The management of patients with carotid artery disease mandates risk factor modification, antiplatelet and statin therapy in everyone. There is grade A, level I evidence that recently symptomatic patients with 50 –99% NASCET stenoses gain significant benefit from carotid endarterectomy (CEA), despite a small risk of perioperative stroke.
Source: Surgery (Medicine Publishing) - April 25, 2018 Category: Surgery Authors: A. Ross Naylor Tags: Vascular surgery – I Source Type: research

Post-operative Infection of Prosthetic Materials or Stents Involving the Supra-aortic Trunks: A Comprehensive Review.
CONCLUSION: Appropriate pre-operative imaging is mandatory and treatment modality should be determined by patient condition. Complete removal of the infected material, followed by in situ arterial reconstruction with venous material seems advisable, despite high morbidity. However, alternative strategies may be considered for fragile and high risk patients. A multidisciplinary approach is mandatory to ensure optimum results. PMID: 30121172 [PubMed - as supplied by publisher]
Source: PubMed: Eur J Vasc Endovasc ... - August 15, 2018 Category: Surgery Authors: Lejay A, Koncar I, Diener H, de Ceniga MV, Chakfé N Tags: Eur J Vasc Endovasc Surg Source Type: research

Safety and efficacy of a new thromboprophylaxis regiment for total knee and total hip replacement: a retrospective cohort study in 265 patients.
Conclusion: The regimen consisting of sequential enoxaparin and rivaroxaban is associated with a significant bleeding risk, although the risk of patients requiring a return to theatre is low. Further prospective trials are required to compare the safety and efficacy profiles of this regimen with established thromboprophylaxis regimens. PMID: 30123323 [PubMed]
Source: Patient Safety in Surgery - August 22, 2018 Category: Surgery Authors: Fallaha MA, Radha S, Patel S Tags: Patient Saf Surg Source Type: research

Invited commentary
Since current guidelines based on randomized clinical trials1-6 have established degree of carotid stenosis as the primary surrogate for stroke risk and indication for carotid endarterectomy or stenting, accurate assessment of the degree of carotid stenosis has been the traditional focus of carotid imaging.7 However, the degree of carotid stenosis is an inadequate assessment of stroke risk, and other key factors for determining carotid plaque vulnerability include intraplaque hemorrhage, plaque rupture, and luminal thrombus.
Source: Journal of Vascular Surgery - November 20, 2018 Category: Surgery Authors: Karen J. Ho Tags: From bench to bedside Source Type: research

Catheter-directed thrombolysis versus suction thrombectomy in the management of acute pulmonary embolism
ConclusionsCDT seems to have similar outcomes with ST in the management of acute PE, although larger, more homogenous data are needed. In our experience, ST should be viewed as a complementary alternative for patients with contraindication for thrombolytics or severely compromised hemodynamic profile and can yield good outcomes in an otherwise highly morbid population.
Source: Journal of Vascular Surgery: Venous and Lymphatic Disorders - March 22, 2019 Category: Surgery Source Type: research

Impact of the physical activity on the phenotype of circulating monocytes and the biological characteristics of the carotid plaque
Atherosclerosis is accompanied by a low-grade inflammation which mobilizes the classical, intermediate and non-classical circulating monocytes. It was shown that an accumulation of leucocytes supports the development of intraplaque hemorrhage (IPH), making the plaque vulnerable, exposed to rupture and thrombosis. Moreover, the elevation of the rate of intermediate monocytes is associated with an increase in cardiovascular mortality and ischemic stroke. The benefit of endarterectomy (CE) remains discussed in the patients without stroke.
Source: Annals of Vascular Surgery - September 24, 2019 Category: Surgery Authors: Mathilde Mura, Mich èle Weiss, Nellie Della Schiava, Marine Bordet, Patrick Lermusiaux, Antoine Millon, Vincent Pialoux Tags: Abstracts Presented to the French Society for Vascular and Endovascular Surgery Source Type: research

Protamine sulfate use during tibial bypass does not appear to increase thrombotic events or affect short-term graft patency.
CONCLUSIONS: Heparin reversal with protamine sulfate after tibial or peroneal bypass grafting is not associated with higher cardiovascular morbidity, bypass thrombosis, amputation, or mortality. Additionally, there was no statistically significant difference in post-operative bleeding or thrombosis complications for patients who did not receive protamine, although the findings are suggestive of a potential difference in a more adequately powered study. Our results suggest that protamine sulfate is safe for intraoperative use without increased risk of thrombotic complications or early tibial bypass graft failure. PMID:...
Source: Vascular - May 10, 2020 Category: Surgery Authors: Phair J, Futchko J, Trestman EB, Carnevale M, Friedmann P, Shukla H, Garg K, Koleilat I Tags: Vascular Source Type: research

Carotid artery disease: clinical features and management
The most common cause of ischaemic carotid territory stroke, around 50% of cases, is thromboembolism from stenoses at the origin of the extracranial internal carotid artery (ICA). Embolism is usually preceded by acute changes in plaque morphology, which predisposes towards overlying thrombus formation and embolization. The management of patients with carotid artery disease involves cardiovascular risk factor modification, antiplatelet and statin therapy in everyone. There is grade A, level I evidence that recently symptomatic patients with 50 –99% stenoses gain significant benefit from carotid endarterectomy (CEA), despi...
Source: Surgery (Medicine Publishing) - April 21, 2021 Category: Surgery Authors: Ross Naylor Tags: Vascular surgery – I Source Type: research