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Valuing health states of people with type 2 diabetes: Analyses of the nationwide representative linked databases
ConclusionsMajor vascular complications, connective tissue disease, and depression are associated with considerably worse HRQoL. These health utility estimates can facilitate health economic evaluations to determine cost ‐effective strategies for diabetes management.
Source: Journal of Diabetes Investigation - February 4, 2021 Category: Endocrinology Authors: Shihchen Kuo, Chun ‐Ting Yang, Hsuan‐Ying Chen, Huang‐Tz Ou Tags: ORIGINAL ARTICLE Source Type: research

Valuing health states of people with type  2 diabetes: Analyses of the nationwide representative linked databases
ConclusionsMajor vascular complications, connective tissue disease and depression are associated with considerably worse health ‐related quality of life. These health utility estimates can facilitate health economic evaluations to determine cost‐effective strategies for diabetes management.
Source: Journal of Diabetes Investigation - March 3, 2021 Category: Endocrinology Authors: Shihchen Kuo, Chun ‐Ting Yang, Hsuan‐Ying Chen, Huang‐Tz Ou Tags: Original Article Source Type: research

Effects of restoring normoglycemia in type 1 diabetes on inflammatory profile and renal extracellular matrix structure after simultaneous pancreas and kidney transplantation
Patients with type 1 diabetes have increased risk of macrovascular complications such as atherosclerotic cardiovascular diseases including myocardial dysfunction and stroke [1,2], as well as microvascular complications including neuropathy, retinopathy and nephropathy [3]. Diabetic nephropathy is characterized by hypertension, albuminuria, reduced glomerular filtration rate (GFR) and kidney morphological changes [4]. These overt effects are the long-term consequences of changes in several important signaling systems affected by hyperglycemia [5], by changes in the renin-angiotensin system, increased transforming growth fac...
Source: Diabetes Research and Clinical Practice - October 27, 2014 Category: Endocrinology Authors: Trine Marita Reine, Ingrid Benedicte Moss Kolseth, Astri Jeanette Meen, Jørn Petter Lindahl, Trond Geir Jenssen, Finn Per Reinholt, Joseph Zaia, Chun Shao, Anders Hartmann, Svein Olav Kolset Source Type: research

Bone Morphogenetic Proteins: Inhibitors of Myelination in Development and Disease.
Abstract Myelin, the lipid membrane that surrounds axons, is critical for the propagation of nervous impulses and axonal maintenance. The destruction of myelin or lack of myelin formation due to disease or injury causes severe motor and cognitive disability. Regeneration of myelin is theoretically possible but rarely happens. Myelin is synthesized as the plasma membrane of the oligodendrocyte in the central nervous system. During development, myelin and oligodendrocytes are generated from oligodendrocyte progenitors through a process modulated by extrinsic growth factors signaling to cell-intrinsic proteins. Among...
Source: Vitamins and Hormones - August 20, 2015 Category: Endocrinology Authors: Grinspan JB Tags: Vitam Horm Source Type: research

ANGPTL2 is associated with an increased risk of cardiovascular events and death in diabetic patients
Conclusions/interpretationIn patients with type 2 diabetes, serum ANGPTL2 concentrations were independently associated with death and MACE. Therefore, ANGPTL2 is a promising candidate biomarker for improving risk stratification in type 2 diabetes patients, and may prove to be a valuable therapeutic target.
Source: Diabetologia - September 30, 2016 Category: Endocrinology Source Type: research

Outcomes in patients with diabetes 10 years after liver transplantation
ConclusionsIn our study, diabetes was associated with a higher risk of liver graft rejection and cardiovascular events. There was also a trend to higher mortality, although the effect was not statistically significant. These findings suggest that patients with diabetes require a more rigorous pretransplant evaluation and closer monitoring after transplantation, in order to try to reduce associated complications.
Source: Journal of Diabetes - December 31, 2016 Category: Endocrinology Authors: Agust ín Ramos‐prol, David Hervás‐marín, Alia GarcÍa‐castell, Juan Francisco Merino‐torres Tags: Original Article Source Type: research

Outcomes in patients with diabetes 10  years after liver transplantation
ConclusionsIn the present study diabetes was associated with a higher risk of liver graft rejection and cardiovascular events. There was also a trend for higher mortality, although the effect was not statistically significant. These findings suggest that patients with diabetes require a more rigorous pretransplant evaluation and closer monitoring after transplantation in order to try to reduce associated complications.
Source: Journal of Diabetes - February 27, 2017 Category: Endocrinology Authors: Agust ín Ramos‐Prol, David Hervás‐Marín, Alia García‐Castell, Juan F. Merino‐Torres Tags: Original Article Source Type: research

Development and Internal Validation of a Discrete Event Simulation Model of Diabetic Kidney Disease Using CREDENCE Trial Data
ConclusionCREDEM-DKD is an important new tool in the evaluation of treatment interventions in the DKD population.Trial RegistrationClinicalTrials.gov identifier, NCT02065791.
Source: Diabetes Therapy - September 14, 2020 Category: Endocrinology Source Type: research

Cost-Effectiveness of Canagliflozin Added to Standard of Care for Treating Diabetic Kidney Disease (DKD) in Patients with Type  2 Diabetes Mellitus (T2DM) in England: Estimates Using the CREDEM-DKD Model
ConclusionModel results suggest that adding canagliflozin 100  mg to SoC can improve patient outcomes while reducing overall net costs from the NHS perspective in England.Trial RegistrationClinicalTrials.gov identifier, NCT02065791.
Source: Diabetes Therapy - December 2, 2020 Category: Endocrinology Source Type: research