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Specialty: Neurology
Condition: ALS
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Total 158 results found since Jan 2013.
TRNA-derived fragments as sex-dependent circulating candidate biomarkers for Parkinson's disease
Parkinson's Disease (PD) is diagnosed clinically. Reliable non-invasive PD biomarkers are actively sought. Transfer RNAs produce short non-coding RNAs, the tRNA-derived fragments (tRF). tRF have been shown to play diverse roles, including in Amyotrophic Lateral Sclerosis, and the response to ischemic stroke. Rich tRF populations are being reported in biofluids. We explored the possibility that tRF can serve as non-invasive biomarkers for PD.
Source: Parkinsonism and Related Disorders - May 24, 2019 Category: Neurology Authors: Rogan Magee, Eric Londin, Isidore Rigoutsos Source Type: research
Repurposing Vorinostat for the Treatment of Disorders Affecting Brain
AbstractBased on the findings in recent years, we summarize the therapeutic potential of vorinostat (VOR), the first approved histone deacetylase (HDAC) inhibitor, in disorders of brain, and strategies to improve drug efficacy and reduce side effects. Scientific evidences provide a strong case for the therapeutic utility of VOR in various disorders affecting brain, including stroke, Alzheimer ’s disease, frontotemporal dementia, Parkinson's disease, Huntington's disease, amyotrophic lateral sclerosis, spinal muscular atrophy, X‐linked adrenoleukodystrophy, epilepsy, Niemann-Pick type C disease, and neuropsychiatric dis...
Source: NeuroMolecular Medicine - May 4, 2021 Category: Neurology Source Type: research
Edaravone attenuates H < sub > 2 < /sub > O < sub > 2 < /sub > or glutamate-induced toxicity in hippocampal neurons and improves AlCl < sub > 3 < /sub > /D-galactose induced cognitive impairment in mice
Neurotoxicology. 2021 May 15:S0161-813X(21)00050-4. doi: 10.1016/j.neuro.2021.05.005. Online ahead of print.ABSTRACTEdaravone (Eda) is a radical scavenger used in clinical trials for the treatment of ischemic stroke and amyotrophic lateral sclerosis. However, how Eda exerts its neuroprotective effects remains to be elucidated. We investigated the neuroprotective effects of Eda in cultured hippocampal neurons and in a mouse model of AlCl3/D-galactose-induced cognitive impairment. Eda protected hippocampal neurons by eliminating H2O2 or glutamate-induced toxicity, leading to decreased cell viability and neurite shortening. C...
Source: Neurotoxicology - May 18, 2021 Category: Neurology Authors: Huan-Tong Wu Yun Yu Xi-Xi Li Xiu-Yuan Lang Run-Ze Gu Sheng-Rui Fan Xin Fang Jin-Peng Bai Rongfeng Lan Xiao-Yan Qin Source Type: research
Neuroprotective Potential of Caffeic Acid Phenethyl Ester (CAPE) in CNS Disorders: Mechanistic and Therapeutic Insights
Curr Neuropharmacol. 2021 Jun 8. doi: 10.2174/1570159X19666210608165509. Online ahead of print.ABSTRACTNeurological disorders like Alzheimer's disease (AD), Parkinson's disease (PD), stroke, amyotrophic lateral sclerosis, Huntington's disease (HD), epilepsy, traumatic brain injury (TBI), depression and anxiety are responsible for thousands of deaths worldwide every year. With the increase in life expectancy, there has been a rise in the prevalence of these disorders. Age is one of the major risk factors for these neurological disorders and with the aged population is set to rise to 1.25 billion by 2050. There is a growing ...
Source: Epilepsy Curr - June 9, 2021 Category: Neurology Authors: Namrata Pramod Kulkarni Bhupesh Vaidya Acharan Narula Shyam Sunder Sharma Source Type: research
Mirror Movements in Acquired Neurological Disorders: A Mini-Review
Mirror movements (MMs) are specifically defined as involuntary movements occurring on one side of homologous muscles when performing unilateral movements with the contralateral limb. MMs have been considered a kind of soft neurological signs, and the persistence or reappearance of MMs in adults is usually pathologic. In addition to some congenital syndrome, MMs have been also described in age-related neurological diseases including pyramidal system diseases (e.g., stroke, amyotrophic lateral sclerosis) and extrapyramidal disorders (e.g., Parkinson's disease, essential tremor). With the advances in instrumentation and detec...
Source: Frontiers in Neurology - September 20, 2021 Category: Neurology Source Type: research
Brain Computer Interfaces for Assisted Communication in Paralysis and Quality of Life
Int J Neural Syst. 2021 Sep 29:2130003. doi: 10.1142/S0129065721300035. Online ahead of print.ABSTRACTThe rapid evolution of Brain-Computer Interface (BCI) technology and the exponential growth of BCI literature during the past 20 years is a consequence of increasing computational power and the achievements of statistical learning theory and machine learning since the 1960s. Despite this rapid scientific progress, the range of successful clinical and societal applications remained limited, with some notable exceptions in the rehabilitation of chronic stroke and first steps towards BCI-based assisted verbal communication in...
Source: International Journal of Neural Systems - September 30, 2021 Category: Neurology Authors: Ujwal Chaudhary Bankim Subhash Chander Avi Ohry Andres Jaramillo-Gonzalez Doroth ée Lulé Niels Birbaumer Source Type: research
