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Effects of vitamin E on neurodegenerative diseases: an update
Acta Neurobiol Exp (Wars). 2021;81(1):21-33. doi: 10.21307/ane-2021-003.ABSTRACTVitamin E deficiency is associated with many neurological problems. Although the mechanisms of vitamin E action in neurodegenerative diseases are not clear, there are many possible mechanisms. Examples of such mechanisms are the protective effects of vitamin E against oxidative stress damage and its suppressive role in the expression of many genes involved in the development of neurodegeneration. Many studies have evaluated the relationship between vitamin E intake or vitamin E levels in body fluids and neurodegenerative diseases. Some studies ...
Source: Acta Neurobiologiae Experimentalis - May 5, 2021 Category: Neurology Authors: Mehmet Arif Icer Neslihan Arslan Makbule Gezmen-Karadag Source Type: research

Use of Veterans Specific Activity Questionnaire VSAQ to Estimate Exercise Tolerance in Ambulatory Amyotrophic Lateral Sclerosis (ambALS) Patients (P2.071)
CONCLUSIONS:VSAQ is a practical tool to estimate exercise capacity of ambALS and may be used for safe exercise prescription.Disclosure: Dr. Sanjak has nothing to disclose. Dr. Headen has nothing to disclose. Dr. Barrett has nothing to disclose. Dr. Holsten has nothing to disclose. Dr. Langford has nothing to disclose. Dr. Bravver has received research support from Biogen Idec, Avanier, Cytokinetics Pharmaceuticals, Neuraltus Pharmaceuticals, GlaxoSmithKline Inc., the National Institute of Neurological Disorders and Stroke, and the Clinical Research Consortium. Dr. Bockenek has nothing to disclose. Dr. Desai has received pe...
Source: Neurology - April 9, 2014 Category: Neurology Authors: Sanjak, M., Headen, J., Barrett, K., Holsten, S., Langford, V., Bravver, E., Bockenek, W., Desai, U., Story, J. S., Lindblom, S. C., Paccico, T., Brooks, B. Tags: ALS: Genetics and Outcomes Source Type: research

Walking Capacity WalkCap Measured by Six-Minute Walk (6MW) Does Not Demonstrate Fatigue in Patients with Amyotrophic Lateral Sclerosis (ALS), Multiple Sclerosis (MS),and Parkinson Disease (PD) (P3.071)
CONCLUSIONS:WalkCap of ambulatory ALS, MS, and PD during 6MW is not affected by motor fatigue. WalkCap was higher in ambulatory patients with stronger grip, faster in TUG and 25FW. WalkCap measured by 6MW can be used as a simple outcome measure to evaluate lower extremity impairments in various neurological diseases. Discordance between WalkCap and the UPDRS-motor scale in mildly affected PD patients indicates that 6MW may provide additional information regarding these patients in clinical practice and clinical research trials.Study Supported by:Carolinas ALS Research Fund, Pinstripes Fund, Carolinas Healthcare Foundation,...
Source: Neurology - April 9, 2014 Category: Neurology Authors: Sanjak, M., Morgan, L., Simpson, A., Holsten, S., Hirsch, M., Englert, D., Iyer, S., Conway, J., Kaufman, M., Bravver, E., Desai, U., Russo, P., Brooks, B. Tags: Movement Disorders: Assessing Parkinson ' s Disease Source Type: research

Serum Creatinine, a Biomarker for Muscle Mass in Amyotrophic Lateral Sclerosis (ALS), Predicts Loss of Ambulation Measured by ALS Functional Rating Scale-Revised Walking Item Score (ALSFRS-Rw) (P4.085)
CONCLUSIONS:Decrease in serum creatinine significantly predicted change in ambulation measured by ALSFRS-Rw longitudinally.Further analysis is required to determine whether leg function alone and leg muscle mass are the major determinants of serum creatinine in ALS patients over the course of the disease.Study Supported by:Carolinas ALS Research Fund/Pinstripes Fund/Carolinas Garden of Hope/Carolinas Healthcare FoundationDisclosure: Dr. Brooks has received personal compensation for activities with Biogen Idec, Avanir Pharmaceuticals, Acorda Therapeutics, Cytokinetics, Synapse, and the National Institute of Neurological Dis...
Source: Neurology - April 9, 2014 Category: Neurology Authors: Brooks, B., Fischer, M., Sanjak, M., Holsten, S., Kandinov, B., Bockenek, W., Bravver, E., Desai, U., Story, J. S., Pacicco, T., Lindblom, S., Langford, V., Wright, K., Ward, A., Lucas, N., Smith, N., Nichols, M., Lary, C., Nemeth, J., Russo, P. Tags: ALS: Trials and Biomarkers Source Type: research

HMGB1 in nervous system diseases: A common biomarker and potential therapeutic target
High-mobility group box-1 (HMGB1) is a nuclear protein associated with early inflammatory changes upon extracellular secretion expressed in various cells, including neurons and microglia. With the progress of research, neuroinflammation is believed to be involved in the pathogenesis of neurological diseases such as Parkinson's, epilepsy, and autism. As a key promoter of neuroinflammation, HMGB1 is thought to be involved in the pathogenesis of Parkinson's disease, stroke, traumatic brain injury, epilepsy, autism, depression, multiple sclerosis, and amyotrophic lateral sclerosis. However, in the clinic, HMGB1 has not been de...
Source: Frontiers in Neurology - October 31, 2022 Category: Neurology Source Type: research

TREM2 in neurodegeneration: evidence for association of the p.R47H variant with frontotemporal dementia and Parkinson's disease
Conclusions: Our results suggest that the TREM2 p.R47H substitution is a risk factor for frontotemporal dementia and Parkinson's disease in addition to Alzheimer's disease. These findings suggest a more general role for TREM2 dysfunction in neurodegeneration, which could be related to its role in the immune response.
Source: Molecular Neurodegeneration - June 21, 2013 Category: Neurology Authors: Sruti RayaproluBianca MullenMatt BakerTimothy LynchElizabeth FingerWilliam SeeleyKimmo HatanpaaCatherine Lomen-HoerthAndrew KerteszEileen BigioCarol LippaKeith JosephsDavid KnopmanCharles WhiteRichard CaselliIan MackenzieBruce MillerMagdalena Boczarska-Je Source Type: research

TREM2 in neurodegeneration: evidence for association of the p.R47H variant with frontotemporal dementia and Parkinson¿s disease
Conclusions: Our results suggest that the TREM2 p.R47H substitution is a risk factor for frontotemporal dementia and Parkinson’s disease in addition to Alzheimer’s disease. These findings suggest a more general role for TREM2 dysfunction in neurodegeneration, which could be related to its role in the immune response.
Source: Molecular Neurodegeneration - June 21, 2013 Category: Neurology Authors: Sruti RayaproluBianca MullenMatt BakerTimothy LynchElizabeth FingerWilliam SeeleyKimmo HatanpaaCatherine Lomen-HoerthAndrew KerteszEileen BigioCarol LippaKeith JosephsDavid KnopmanCharles WhiteRichard CaselliIan MackenzieBruce MillerMagdalena Boczarska-Je Source Type: research

Dextromethorphan and Quinidine for Treatment of Pseudobulbar Affect (PBA): Time Course of PBA Episode Remission (S31.007)
Conclusions: Approximately half of patients receiving DMQ-20 experienced PBA episode remission during this 12-week pivotal trial. Significant differences vs. placebo in the percentage of patients entering remission emerged early (Week 1) and remained significant in subsequent trial weeks.Study Supported by: Avanir Pharmaceuticals, Inc.Disclosure: Dr. Formella has received personal compensation for activities with Avanir Pharmaceuticals Inc. as an employee. Dr. Brooks has received personal compensation for activities with Biogen Idec, Avanir Pharmaceuticals, Acorda Therapeutics, Cytokinetics, Synapse, and the National Insti...
Source: Neurology - April 9, 2014 Category: Neurology Authors: Formella, A., Brooks, B. Tags: General Neurology I Source Type: research

Amyotrophic Lateral Sclerosis Quality Measures (S46.006)
CONCLUSIONS: The AAN ALS quality measures, when implemented by providers, have the potential to significantly improve care for individuals with ALS.Study Supported by:Disclosure: Dr. Miller has received personal compensation for activities with Celgene, Pharmacyclic, Teva Neuroscience, and Taiji. Dr. Brooks has received personal compensation for activities with Biogen Idec, Avanir Pharmaceuticals, Acorda Therapeutics, Cytokinetics, Synapse, and the National Institute of Neurological Disorders and Stroke. Dr. Brooks has received research support from Biogen Idec, Avanir Pharmaceuticals, Cytokinetics, Neuraltus Pharmaceutica...
Source: Neurology - April 9, 2014 Category: Neurology Authors: Miller, R., Brooks, B., Swain-Eng, R., Basner, R., Carter, G., Casey, P., Cohen, A., Dubinsky, R., Forshew, D., Jackson, C., Kasarskis, E., Procaccini, N., Sanjak, M., Tolin, F. Tags: Neuromuscular Disease: Genetics, Pathogenesis, and Measures Source Type: research

Risks of Epilepsy During Pregnancy
Epilepsy is a common disease that affects 1 in 26 individuals in their lifetime. According to a National Institute of Neurological Disorders and Stroke assessment, with 2 million affected individuals, epilepsy ranks only fourth to migraine, stroke, and Alzheimer disease in the prevalence of neurological disorders. Epilepsy affects more people than autism, amyotrophic lateral sclerosis, cerebral palsy, multiple sclerosis, and Parkinson disease combined. Approximately 0.3% to 0.5% of all pregnancies are among women with epilepsy (WWE). The risks during pregnancy in WWE have been uncertain.
Source: JAMA Neurology - July 6, 2015 Category: Neurology Source Type: research

Evidence for the Importance of Vitamin D Status in Neurologic Conditions
Opinion statement Vitamin D status has been proposed as relevant to many neurological disorders. Data suggest that vitamin D may be important for the development of the nervous system, and it also plays a role in neuroimmunology and neuroprotection. Lower levels of circulating 25-hydroxyvitamin D have been linked with increased risk of multiple sclerosis (MS) and Alzheimer’s disease (AD). While people with amyotrophic lateral sclerosis (ALS), Parkinson’s disease (PD), and stroke have lower vitamin D levels than those without the diseases, it is unclear if this is because hypovitaminosis D contributes to disea...
Source: Current Treatment Options in Neurology - November 4, 2015 Category: Neurology Source Type: research

Sexuality and disability, a poorly studied relationship in neurology (P2.199)
Conclusions:Sexual dysfunction was more frequent in patients with chronic neurological diseases. We found a statistically significant relationship between sexual dysfunction and disability. For overall sexual function, the results indicate that women had lower rates of sexual performance for the same degree of disability than menDisclosure: Dr. Nasimbera has nothing to disclose. Dr. Rosales has nothing to disclose. Dr. Quarrachino has nothing to disclose. Dr. Rodriquez has nothing to disclose.
Source: Neurology - April 17, 2017 Category: Neurology Authors: Nasimbera, A., Rosales, J., Silva, B., Alonso, R., Bohorquez, N., Lepera, S., Garreto, N., Tomoko, A., Garcea, O., Raul, R., Quarrachino, C., Rodriquez, G. Tags: General Neurology: Practice Improvement and Novel Approaches to Care Source Type: research

Current Clinical Applications of Diffusion-Tensor Imaging in Neurological Disorders.
Authors: Tae WS, Ham BJ, Pyun SB, Kang SH, Kim BJ Abstract Diffusion-tensor imaging (DTI) is a noninvasive medical imaging tool used to investigate the structure of white matter. The signal contrast in DTI is generated by differences in the Brownian motion of the water molecules in brain tissue. Postprocessed DTI scalars can be used to evaluate changes in the brain tissue caused by disease, disease progression, and treatment responses, which has led to an enormous amount of interest in DTI in clinical research. This review article provides insights into DTI scalars and the biological background of DTI as a relative...
Source: Journal of Clinical Neurology - March 7, 2018 Category: Neurology Tags: J Clin Neurol Source Type: research

Everything you always wanted to know about sex and Neurology: neurological disability and sexuality
Conclusions Disability proved to be the main variable related to the presence of sexual dysfunction. Patients with ALS had the worst rates of sexual dysfunction. Patients with MS were similar to the control group. As for the PD group, no patient had normal sexuality. Finally, in stroke patients, the presence of comorbidities and their treatment may have negatively influenced sexuality. These findings showed that patients with chronic neurological diseases have sexual dysfunction and underscore the need for neurologists to know and address this problem.RESUMO Las enfermedades neurol ógicas crónicas generan discapacidad af...
Source: Arquivos de Neuro-Psiquiatria - July 26, 2018 Category: Neurology Source Type: research

An Automated Tongue Tracker for Quantifying Bulbar Function in ALS
DiscussionTT may serve to detect quantitative markers of bulbar dysfunction in ALS and other motor disorders, such as stroke, by identifying signatures of spasticity or muscle weakness that affects tongue movement speed and/or tongue movement topography.
Source: Frontiers in Neurology - February 25, 2022 Category: Neurology Source Type: research

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