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Specialty: Cardiology
Condition: Patent Foramen Ovale

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Total 614 results found since Jan 2013.

Percutaneous Patent Foramen Ovale Closure After Stroke
Korean Circ J. 2022 Nov;52(11):801-807. doi: 10.4070/kcj.2022.0258.ABSTRACTPercutaneous patent foramen ovale (PFO) closure in patients with a prior PFO-associated stroke showed a risk reduction of the stroke recurrence compared to the medical therapy alone in recent several studies. Nevertheless, optimal patient selection for PFO closure has not been clarified. In this paper, we discuss the characteristics of PFO-associated strokes and discuss the recently published evidence and patient selection for PFO closure in patients with ischemic stroke. The lesions characteristics of PFO-associated stroke are associated with multi...
Source: Korean Circulation Journal - November 8, 2022 Category: Cardiology Authors: Oh-Hyun Lee Jung-Sun Kim Source Type: research

PFO closure vs. medical therapy in cryptogenic stroke or transient ischemic attack: A systematic review and meta-analysis
Conclusions: This meta-analysis does not support PFO closure for secondary prevention with unselected devices in cryptogenic stroke/TIA. In subgroup analysis, selected closure devices may be superior to medical therapy without increasing the risk of new-onset AF, however. This observation should be confirmed in further trials using inclusion criteria for patients with high likelihood of PFO-related stroke recurrence.
Source: International Journal of Cardiology - September 16, 2013 Category: Cardiology Authors: G. Ntaios, V. Papavasileiou, K. Makaritsis, P. Michel Tags: Reviews Source Type: research

Amplatzer PFO Occluder Device may Prevent Recurrent Stroke in Patients with Patent Foramen Ovale and Cryptogenic Stroke: A Meta-Analysis of Randomised Trials
Conclusion: The closure of PFO with Amplatzer PFO occluder device was associated with significant reduction in recurrent strokes in patients with cryptogenic stroke and patent foramen ovale. The better outcome in prevention of secondary stroke in patients with cryptogenic stroke and PFO may be associated with type of closure device used.
Source: Heart, Lung and Circulation - February 4, 2014 Category: Cardiology Authors: Anil Pandit, Madan Raj Aryal, Aashrayata Aryal Pandit, Leena Jalota, Sudheer Kantharajpur, Fayaz A. Hakim, Howard R. Lee Tags: Reviews Source Type: research

Percutaneous Closure versus Medical Therapy Alone for Cryptogenic Stroke Patients with a Patent Foramen Ovale: Meta-Analysis of Randomized Controlled Trials.
Abstract Of cryptogenic stroke patients younger than 55 years of age, up to 61% have had a patent foramen ovale (PFO). Observational studies have revealed reductions in recurrent neurologic events through PFO closure versus medical therapy, and randomized controlled trials have shown nonsignificant trends toward benefit. We systematically searched for randomized controlled trials of percutaneous PFO closure with medical therapy versus medical therapy alone in patients with cryptogenic stroke and performed a meta-analysis of treatment outcomes. The primary endpoint was combined death, stroke, and transient ischemic...
Source: Texas Heart Institute Journal - August 1, 2014 Category: Cardiology Authors: Pickett CA, Villines TC, Ferguson MA, Hulten EA Tags: Tex Heart Inst J Source Type: research

Usefulness of transesophageal echocardiography to optimize treatment after ischemic stroke.
CONCLUSIONS: In the setting of ischemic stroke, TEE provides important additional informations, but modifies therapeutic strategy in less than 10% of cases. Multivessel territory stroke, and left atrial dilatation were predictive of DTEE. PMID: 25245599 [PubMed - as supplied by publisher]
Source: Annales de Cardiologie et d'Angeiologie - September 4, 2014 Category: Cardiology Authors: Charbonnel C, Fanon L, Georges JL, Colonna G, Stefas L, Isorni C, Convers-Domart R, Galuscan G, Baron N, Pico F, Livarek B Tags: Ann Cardiol Angeiol (Paris) Source Type: research

PFO Closure for Cryptogenic Stroke
Abstract A patent foramen ovale (PFO) is a common finding in the general population and has been theorized to be a mechanism for ischemic stroke primarily due to a deep venous thrombus embolizing through the shunt into the arterial circulation. There has been much debate regarding the association between PFO and stroke, especially in the case of a cryptogenic stroke (i.e., stroke of unknown etiology) in a younger patient without other risk factors. Traditionally, when a PFO is detected, antithrombotic therapy to mitigate risk of a future ischemic event has been the mainstay of treatment. More recently, both surgi...
Source: Current Atherosclerosis Reports - June 17, 2015 Category: Cardiology Source Type: research

Anticoagulant vs. antiplatelet therapy in patients with cryptogenic stroke and patent foramen ovale: an individual participant data meta-analysis
Conclusion We did not find a statistically significant difference comparing OAC with APT; our results justify randomized trials comparing different antithrombotic approaches in these patients.
Source: European Heart Journal - September 14, 2015 Category: Cardiology Authors: Kent, D. M., Dahabreh, I. J., Ruthazer, R., Furlan, A. J., Weimar, C., Serena, J., Meier, B., Mattle, H. P., Di Angelantonio, E., Paciaroni, M., Schuchlenz, H., Homma, S., Lutz, J. S., Thaler, D. E. Tags: Thrombosis and antithrombotic therapy Source Type: research

Endocardial Device Leads in Patients with Patent Foramen Ovale: Echocardiographic Correlates of Stroke/TIA and Mortality
ConclusionsIn patients with CIED and PFO, structural and hemodynamic echocardiographic markers did not predict future stroke/TIA. However, a significantly higher TR or RVSP was associated with higher mortality.This article is protected by copyright. All rights reserved
Source: Pacing and Clinical Electrophysiology : PACE - October 31, 2016 Category: Cardiology Authors: SHIVA P. PONAMGI, VAIBHAV R. VAIDYA, CHRISTOPHER V. DESIMONE, AMIT NOHERIA, DAVID O. HODGE, JOSHUA P. SLUSSER, NASER M. AMMASH, CHARLES J. BRUCE, ALEJANDRO A. RABINSTEIN, PAUL A. FRIEDMAN, SAMUEL J. ASIRVATHAM Tags: BASIC SCIENCE Source Type: research

Relationship between mean platelet volume and ischemic stroke in patients with patent foramen ovale.
CONCLUSION: MPV is higher in symptomatic than in asymptomatic PFO patients. This finding may be a subsidiary risk factor to identify patients with PFO and high risk of cardioembolic stroke. PMID: 28106015 [PubMed - in process]
Source: Turk Kardiyoloji Dernegi arsivi - December 31, 2016 Category: Cardiology Authors: Bayar N, Küçükseymen S, Erkal Z, Güven R, Köklü E, Üreyen ÇM, Arslan Ş Tags: Turk Kardiyol Dern Ars Source Type: research

Cryptogenic Stroke and Patent Foramen Ovale Risk Assessment
Publication date: Available online 29 June 2017 Source:Interventional Cardiology Clinics Author(s): Emiliya Melkumova, David E. ThalerTeaser Stroke is a devastating condition. It is the fifth leading cause of death in the United States, and a leading cause of serious long-term disability. Stroke occurs at any age. Younger patients tend to have strokes of undetermined cause, termed cryptogenic. Herein, the authors describe the classification of stroke cause; the risk of recurrent cryptogenic stroke with patent foramen ovale (PFO); a risk assessment model to stratify incidental versus a pathogenic PFO in patients presenting...
Source: Interventional Cardiology Clinics - June 30, 2017 Category: Cardiology Source Type: research

Clinical outcomes of secondary prevention strategies for young patients with cryptogenic stroke and patent foramen ovale.
Conclusions The diagnosis of stroke in patients with PFO could be confirmed in 50% of cases only, underlining the importance of a multidisciplinary evaluation of these patients. A very low ischaemic recurrence rate was observed in the medical therapy group, suggesting that a personalized treatment based on a prespecified diagnostic algorithm yields good clinical results irrespective of the treatment modality. Given the low number of recurrences, larger cohorts may be needed to prove significant differences. PMID: 28705105 [PubMed - as supplied by publisher]
Source: Acta Cardiologica - July 15, 2017 Category: Cardiology Tags: Acta Cardiol Source Type: research

Percutaneous closure of a  patent foramen ovale after cryptogenic stroke.
Percutaneous closure of a patent foramen ovale after cryptogenic stroke. Neth Heart J. 2017 Dec 04;: Authors: Snijder RJR, Suttorp MJ, Ten Berg JM, Post MC Abstract A patent foramen ovale is a common intracardiac finding that is located between the left and right atrium. It can cause right-to-left shunting and has a high prevalence in patients who suffer a cryptogenic stroke. Earlier trials did not show superiority of percutaneous patent foramen ovale closure with standard medical therapy over standard medical therapy alone in the treatment of cryptogenic stroke. Interestingly, several meta-analy...
Source: Netherlands Heart Journal - December 4, 2017 Category: Cardiology Authors: Snijder RJR, Suttorp MJ, Ten Berg JM, Post MC Tags: Neth Heart J Source Type: research

Closure of the patent foramen ovale (PFO) in cryptogenic stroke.
Authors: Diener HC, Knebel F Abstract Autopsy studies and echocardiographic investigations have shown that around 20-25% of the healthy population have a patent foramen ovale (PFO). In patients younger than 55 years the risk of a cryptogenic stroke is increased in the presence of a PFO. The first three randomized studies could not demonstrate superiority of an interventional closure of a PFO compared to antithrombotic treatment in patients with cryptogenic stroke. The results of three recently published studies and the extension of an earlier study showed a superiority of an interventional closure of a PFO comp...
Source: Herz - April 5, 2019 Category: Cardiology Tags: Herz Source Type: research

Device Closure of Patent Foramen Ovale for Cryptogenic Stroke: Patient Selection and Outcomes According to New Randomized Trials
AbstractPurpose of ReviewThis review summarizes the most recent randomized clinical trials that studied the role of device-mediated patent foramen ovale (PFO) closure in patients after an ischemic stroke presumed to have been caused by a paradoxical embolism.Recent FindingsThree major randomized trials published in 2017 studied the strategy of using PFO closure for secondary prevention in patients between the ages of 18 and 60 who presented with an index stroke having characteristics of an embolic mechanism. All patients had a PFO that potentially could have enabled paradoxical embolism and other causes of stroke were excl...
Source: Current Cardiology Reports - April 21, 2019 Category: Cardiology Source Type: research