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Clopidogrel increases risk of pneumonia compared with aspirin in acute ischemic minor stroke patients
AbstractAntiplatelet agents may increase the risk of infections via suppressing platelet-mediated immune response. Here we assessed the contribution of clopidogrel versus aspirin to the development of pneumonia during an acute ischemic stroke admission. A retrospective cohort study was conducted of acute ischemic stroke patients who were admitted to our hospital from 2015 to 2018. Included patients received uninterrupted clopidogrel or aspirin therapy and did not take other antiplatelet agents throughout their stay. The interest outcome was development of pneumonia after stroke. Conditional logistic regression model after ...
Source: Journal of Thrombosis and Thrombolysis - October 9, 2020 Category: Hematology Source Type: research

Prospective pilot study of tirofiban in progressive stroke after intravenous thrombolysis
ConclusionEarly treatment with low-dose tirofiban in AIS patients with neurologic deterioration after IVT potentially improved functional recovery and attenuated neurologic deficits as early as 7 days and did not increase the risk of various hemorrhagic complications. However, the therapeutic efficacy of tirofiban treatment in END patients needs to be determined by future randomized clinical trials with a large study population.Clinical trial registrationhttp://www.chictr.org.cn/, Identifier ChiCTR2200058513.
Source: Frontiers in Neurology - October 4, 2022 Category: Neurology Source Type: research

Can aspirin reduce heart attack and stroke risk in patients with pneumonia?
A pneumonia trial – the largest ever – will investigate whether aspirin can reduce the risk of a heart attack or stroke in patients who are admitted to hospital with pneumonia.
Source: University of Bristol news - May 9, 2023 Category: Universities & Medical Training Tags: Health, International, Research; Faculty of Health Sciences, Faculty of Health Sciences, Translational Health Sciences; Press Release Source Type: news

Janssen to Present the Strength and Promise of its Hematologic Malignancies Portfolio and Pipeline at ASH 2021
RARITAN, N.J., November 4, 2021 – The Janssen Pharmaceutical Companies of Johnson & Johnson announced today that more than 45 company-sponsored abstracts, including 11 oral presentations, plus more than 35 investigator-initiated studies will be featured at the American Society of Hematology (ASH) Annual Meeting and Exposition. ASH is taking place at the Georgia World Congress Center in Atlanta and virtually from December 11-14, 2021.“We are committed to advancing the science and treatment of hematologic malignancies and look forward to presenting the latest research from our robust portfolio and pipeline during ASH...
Source: Johnson and Johnson - November 5, 2021 Category: Pharmaceuticals Tags: Innovation Source Type: news

Aspirin reduces cardiovascular events in patients with pneumonia: a prior event rate ratio analysis in a large primary care database
This study provides supporting evidence that aspirin use is associated with reduced ischaemic events after pneumonia in a primary care setting. This drug may have a future clinical role in preventing this important complication.
Source: European Respiratory Journal - February 11, 2021 Category: Respiratory Medicine Authors: Hamilton, F., Arnold, D., Henley, W., Payne, R. A. Tags: Original Articles: Pulmonary infection Source Type: research

Anton–Babinski syndrome in an old patient: a case report and literature review
Abstract Anton–Babinski syndrome is a rare disease featuring bilateral cortical blindness and anosognosia with visual confabulation, but without dementia or any memory impairment. It has a unique neuropsychiatric presentation and should be highly suspected in those with odd visual loss and imaging evidence of occipital lobe injury. In the case discussed herein, a 90‐year‐old man presented with bilateral blindness, obvious anosognosia, and vivid visual confabulation, which he had had for 3 days. Brain computed tomography demonstrated recent hypodense infarctions at the bilateral occipital lobes. Thus, the patient was ...
Source: Psychogeriatrics - December 16, 2014 Category: Geriatrics Authors: Jiann‐Jy Chen, Hsin‐Feng Chang, Yung‐Chu Hsu, Dem‐Lion Chen Tags: CASE REPORT Source Type: research

Lower Mortality Rate in Elderly Patients With Community-Onset Pneumonia on Treatment With Aspirin Epidemiology
Conclusions This study shows that chronic aspirin use is associated with lower mortality rate within 30 days after hospital admission in a large cohort of patients with pneumonia.
Source: JAHA:Journal of the American Heart Association - January 6, 2015 Category: Cardiology Authors: Falcone, M., Russo, A., Cangemi, R., Farcomeni, A., Calvieri, C., Barilla, F., Scarpellini, M. G., Bertazzoni, G., Palange, P., Taliani, G., Venditti, M., Violi, F. Tags: Epidemiology Source Type: research

Impact of aspirin use on morbidity and mortality in massively transfused cardiac surgery patients: a propensity score matched cohort study
Conclusions Preoperative aspirin use is not associated with decreased in-hospital mortality in massively transfused cardiac surgery patients, but may be associated with less mechanical lung ventilation time.
Source: Journal of Anesthesia - July 4, 2016 Category: Anesthesiology Source Type: research

Scimitar Syndrome Repair in Adults: Intermediate-Term Results Using an Extracardiac Conduit
Conclusions Correction of scimitar syndrome with an extracardiac conduit can be easily and safely performed in adults, with excellent intermediate-term durability, without graft thrombi or stenosis. This technique avoids deep hypothermic circulatory arrest when the SV is short or enters the IVC in an unusually caudad location.
Source: The Annals of Thoracic Surgery - July 15, 2016 Category: Cardiovascular & Thoracic Surgery Source Type: research

Scimitar Syndrome Repair in Adults: Intermediate-Term Results Using an Extracardiac Conduit.
CONCLUSIONS: Correction of scimitar syndrome with an extracardiac conduit can be easily and safely performed in adults, with excellent intermediate-term durability, without graft thrombi or stenosis. This technique avoids deep hypothermic circulatory arrest when the SV is short or enters the IVC in an unusually caudad location. PMID: 27424466 [PubMed - as supplied by publisher]
Source: The Annals of Thoracic Surgery - July 13, 2016 Category: Cardiovascular & Thoracic Surgery Authors: Guerra NC, Pernot M, Nesseris G, Al-Yamani M, Roques X, Thambo JB, Kreitmann B, Roubertie F Tags: Ann Thorac Surg Source Type: research

Refractory Mycoplasma pneumoniae pneumonia with concomitant acute cerebral infarction in a child: A case report and literature review
We present a 7-year-old boy with severe M pneumoniae pneumonia who developed impaired consciousness, aphasia, and reduced limb muscle power 7 days postadmission. Diagnoses: Mycoplasma pneumoniae pneumonia with concomitant acute cerebral infarction. Interventions: The patient recovered with aggressive antibiotic therapy, antiinflammation therapy with methylprednisolone, and gamma immunoglobulin and anticoagulation therapy with aspirin and low molecular weight heparin along with rehabilitation training. Outcomes: At 8 days postadmission, his consciousness was improved and at the 6-month follow-up visit, his muscle p...
Source: Medicine - March 1, 2018 Category: Internal Medicine Tags: Research Article: Clinical Case Report Source Type: research

Established evidence-based treatment guidelines help mitigate disparities in quality of emergency care.
CONCLUSIONS: Long-standing, nationally reported evidence-based guidelines can help eliminate sex and race/ethnicity disparities in quality of care. When providers know their care is being monitored and reported, their implicit biases may be less likely to impact care. PMID: 33599040 [PubMed - as supplied by publisher]
Source: Accident and Emergency Nursing - February 18, 2021 Category: Emergency Medicine Authors: Trent SA, George N, Havranek EP, Ginde AA, Haukoos JS Tags: Acad Emerg Med Source Type: research

Thrombosis in Covid-19 and non-Covid-19 pneumonia: role of platelets
Platelets. 2021 Jun 7:1-9. doi: 10.1080/09537104.2021.1936478. Online ahead of print.ABSTRACTPlatelets may be a target of bacteria and viruses, which can directly or indirectly activate them so promoting thrombosis. In accordance with this, community-acquired pneumonia (CAP) is complicated by ischemia-related vascular disease (myocardial infarction and stroke) in roughly 10% of patients while the incidence of venous thrombosis is uncertain. In CAP platelet biosynthesis of TxA2 is augmented and associated with myocardial infarction; however, a cause-effect relationship is still unclear as unclear is if platelet activation p...
Source: Platelets - June 7, 2021 Category: Hematology Authors: Francesco Violi Vittoria Cammisotto Pasquale Pignatelli Source Type: research

Study shows aspirin can reduce the risk of heart attacks and strokes in patients with pneumonia
Aspirin can reduce the risk of serious cardiovascular events such as ischemic stroke and heart attack in patients with pneumonia, according to new research.
Source: University of Bristol news - July 7, 2021 Category: Universities & Medical Training Tags: Research; Faculty of Health Sciences, Faculty of Health Sciences, Bristol Medical School; Press Release Source Type: news

Low-Dose Aspirin Cuts Heart Risks in Patients Battling Pneumonia
THURSDAY, July 8, 2021 -- Aspirin has long been taken by heart patients to reduce the risk of stroke and heart attack, but a new study suggests that it can also guard against cardiovascular trouble in pneumonia patients. Such complications are...
Source: Drugs.com - Daily MedNews - July 8, 2021 Category: General Medicine Source Type: news