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Specialty: Neurology
Condition: Parkinson's Disease
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Total 502 results found since Jan 2013.
Dysphagia in Neurological Disorders
Semin Neurol DOI: 10.1055/s-0043-1771458Dysphagia is a common symptom in many neurologic disorders. Patients with oropharyngeal dysphagia present with difficulties when they start to swallow, often with coughing and choking; whereas patients with esophageal dysphagia describe the feeling that swallowed food stops in the chest. Chronic neurologic diseases such stroke, Parkinson's disease, or dementia often have dysphagia as a symptom, particularly oropharyngeal dysphagia, and the term “neurogenic dysphagia” is often used. A disruption of the sophisticated, integrated sensorimotor swallowing system is usually the main re...
Source: Seminars in Neurology - August 14, 2023 Category: Neurology Authors: El Halabi, Maan Arwani, Remy Parkman, Henry P. Tags: Review Article Source Type: research
Sarcopenia in acute ischemic stroke patients and patients with Parkinson ’s disease
Background: Sarcopenia is a condition characterized by a progressive generalized loss of skeletal muscle mass and strength. The most common nutritional problem that predisposes an ischemic stroke (IS) is sarcopenia. In patients with Parkinson's disease (PD), sarcopenia may represent the common downstream pathway that, from motor and non-motor symptoms leads to the progressive loss of resilience, frailty, and disability.
Source: Parkinsonism and Related Disorders - August 1, 2023 Category: Neurology Authors: S. Mandjikoska, G. Horvat Pinteri ć Source Type: research
Impact of injection guidance techniques on the efficacy and safety of incobotulinumtoxinA for sialorrhea
Background:SIAXI (NCT02091739), a double-blind, randomized, placebo-controlled study, assessed the efficacy and safety of incobotulinumtoxinA 75 or 100 U in patients with sialorrhea due to Parkinson ’s disease (PD), atypical parkinsonism, stroke or traumatic brain injury. This subgroup analysis assessed the impact of injection guidance technique.
Source: Parkinsonism and Related Disorders - August 1, 2023 Category: Neurology Authors: W. Jost, F. Pagan, O. Michel, C. Oehlwein, J. Slawek, A. Bogucki, S. Ochudlo, M. Banach, B. Flatau-Baqu é, J. Csikos, A. Blitzer Source Type: research
Placebo-controlled, randomized, double-blind study of incobotulinumtoxinA for sialorrhea
Background:This pivotal phase III study, SIAXI, investigated the efficacy and safety of incobotulinumtoxinA for the treatment of chronic sialorrhea due to Parkinson disease (PD), atypical parkinsonism, stroke, or traumatic brain injury (TBI).
Source: Parkinsonism and Related Disorders - August 1, 2023 Category: Neurology Authors: W. Jost, A. Friedman, O. Michel, C. Oehlwein, J. Slawek, A. Bogucki, S. Ochudlo, M. Banach, F. Pagan, B. Flatau-Baqu é, J. Csikos, C.J. Cairney, A. Blitzer Source Type: research
Attainment of physiologic salivary flow rate with long-term incobotulinumtoxinA treatment for sialorrhea in Parkinson ’s disease and other neurologic conditions
Background: We investigated the effect of repeated incobotulinumtoxinA injections on salivary flow rate in adults with chronic sialorrhea due to Parkinson ’s disease (PD), atypical parkinsonism, stroke or traumatic brain injury in the 64-week SIAXI study.
Source: Parkinsonism and Related Disorders - August 1, 2023 Category: Neurology Authors: W. Jost, F. Pagan, A. Friedman, O. Michel, C. Oehlwein, J. Slawek, A. Bogucki, S. Ochudlo, M. Banach, B. Flatau-Baqu é, J. Csikos, A. Blitzer Source Type: research
Evaluation of extrapyramidal diseases with Parkinson ’s disease in patients suffering from stroke in Tashkent region, Uzbekistan
Background:Much attention has appealed to the frequency of stroke and neurodegenerative diseases correlated with the age of the patient. To determine the incidence and clinical characteristics of PD in patients with stroke.
Source: Parkinsonism and Related Disorders - August 1, 2023 Category: Neurology Authors: J. Sabirov, U. Azamat, R. Yuldashev Source Type: research
Telephone assistance for neurological diseases: a systematic review
CONCLUSIONS: Dementias are the diseases with more bibliographic references on their telephone assistance despite not being the most prevalent. The telephone is frequently used to administer diagnostic scales or support caregivers and is particularly useful in diseases that limit mobility and attending a medical practice.PMID:37466132 | DOI:10.33588/rn.7703.2022284
Source: Revista de Neurologia - July 19, 2023 Category: Neurology Authors: J M Trejo-Gabriel-Gal án E Cubo-Delgado Source Type: research
New insights on the potential effect of vinpocetine in Parkinson ’s disease: one of the neglected warden and baffling topics
In conclusion, this review indicated that VPN could be effective in the management of PD.
Source: Metabolic Brain Disease - June 19, 2023 Category: Neurology Source Type: research
Validity, reliability and minimal detectable change of Mini-BESTest Turkish version in neurological disorders
ConclusionsMini-BESTestTR showed significant correlations with other balance assessment measures, and concurrent and convergent validity of Mini-BESTestTR was demonstrated when administered to a sample of patients with chronic stroke, Parkinson ’s disease and multiple sclerosis.
Source: Acta Neurologica Belgica - June 16, 2023 Category: Neurology Source Type: research
Epigenetic Regulation of Ferroptosis in Central Nervous System Diseases
AbstractFerroptosis, a newly identified form of cell death, is characterized by iron overload and accumulation of lipid reactive oxygen species. Inactivation of pathways, such as glutathione/glutathione peroxidase 4, NAD(P)H/ferroptosis suppressor protein 1/ubiquinone, dihydroorotate dehydrogenase/ubiquinol, or guanosine triphosphate cyclohydrolase-1/6(R)-l-erythro-5,6,7,8-tetrahydrobiopterin pathways, have been found to induce ferroptosis. The accumulating data suggest that epigenetic regulation can determine cell sensitivity to ferroptosis at both the transcriptional and translational levels. While many of the effectors ...
Source: Molecular Neurobiology - May 28, 2023 Category: Neurology Source Type: research
Natural killer cells in aging and age-related diseases
Neurobiol Dis. 2023 May 18:106156. doi: 10.1016/j.nbd.2023.106156. Online ahead of print.ABSTRACTAging leads to escalated systemic inflammation. As the sentinel of immune system, natural killer (NK) cells are early responders that sense cues and signals from target organs and swiftly orchestrate local inflammation upon their arrival. Emerging evidence indicates a profound role of NK cells in the initiation and evolution of neuroinflammation in aging and age-related diseases. Here we discuss recent advances in NK cell biology and the organ-specific features of NK cells in normal brain aging, Alzheimer's disease, Parkinson's...
Source: Neurobiology of Disease - May 20, 2023 Category: Neurology Authors: Caiyun Qi Qiang Liu Source Type: research
