Filtered By:
Condition: Pain
Nutrition: Sodium
This page shows you your search results in order of date.
Order by Relevance | Date
Total 1100 results found since Jan 2013.
Peripheral temperature dysregulation associated with functionally altered Na < sub > V < /sub > 1.8 channels
Pflugers Arch. 2023 Sep 11. doi: 10.1007/s00424-023-02856-2. Online ahead of print.ABSTRACTThe voltage-gated sodium channel NaV1.8 is prominently expressed in the soma and axons of small-caliber sensory neurons, and pathogenic variants of the corresponding gene SCN10A are associated with peripheral pain and autonomic dysfunction. While most disease-associated SCN10A variants confer gain-of-function properties to NaV1.8, resulting in hyperexcitability of sensory neurons, a few affect afferent excitability through a loss-of-function mechanism. Using whole-exome sequencing, we here identify a rare heterozygous SCN10A missense...
Source: Pflugers Archiv : European Journal of Physiology - September 11, 2023 Category: Physiology Authors: Simon Loose Annette Lischka Samuel Kuehs Carla Nau Stefan H Heinemann Ingo Kurth Enrico Leipold Source Type: research
Employing the sustained-release properties of poly(lactic-co-glycolic acid) nanoparticles to reveal a novel mechanism of sodium-hydrogen exchanger 1 in neuropathic pain
Transl Res. 2023 Sep 5:S1931-5244(23)00143-3. doi: 10.1016/j.trsl.2023.09.003. Online ahead of print.ABSTRACTNeuropathic pain is caused by injury or disease of the somatosensory system, and its course is usually chronic. Several studies have been dedicated to investigating neuropathic pain-related targets; however, little attention has been paid to the persistent alterations that these targets, some of which may be crucial to the pathophysiology of neuropathic pain. The present study aimed to identify potential targets that may play a crucial role in neuropathic pain and validate their long-term impact. Through bioinformat...
Source: Translational Research : the journal of laboratory and clinical medicine - September 7, 2023 Category: Laboratory Medicine Authors: Junhua Wu Meiling Jin Quangdon Tran Minwoo Kim Song I Kim Juhee Shin Hyewon Park Nara Shin Hyunji Kang Hyo Jung Shin Sun Yeul Lee Song-Biao Cui C Justin Lee Won Hyung Lee Dong Woon Kim Source Type: research
The effect of parecoxib sodium combined with perioperative psychological care on postoperative pain in elderly patients with hip fractures
CONCLUSIONS: Perioperative psychological nursing combined with preemptive analgesia of parecoxib sodium has a significant positive effect on elderly patients with hip fractures after surgery. The combined nursing intervention can further alleviate postoperative pain, improve patients' psychological status, promote the recovery of hip joint function, and significantly improve the daily living ability and quality of life of patients. The combined intervention plan is worthy of clinical promotion and application.PMID:37667953 | DOI:10.26355/eurrev_202308_33429
Source: Pharmacological Reviews - September 5, 2023 Category: Drugs & Pharmacology Authors: H-Y Ai M-Y Cheng Source Type: research
Safety and efficacy of the epithelial sodium channel blocker idrevloride in people with primary ciliary dyskinesia (CLEAN-PCD): a multinational, phase 2, randomised, double-blind, placebo-controlled crossover trial
Lancet Respir Med. 2023 Aug 31:S2213-2600(23)00226-6. doi: 10.1016/S2213-2600(23)00226-6. Online ahead of print.ABSTRACTBACKGROUND: Mucociliary clearance is dysfunctional in people with primary ciliary dyskinesia, resulting in the accumulation of dehydrated mucus in the airways that is difficult to clear. We undertook a study to assess the benefit on lung function of treatment with a nebulised epithelial sodium channel (ENaC) blocker, idrevloride, with or without hypertonic saline, in people with primary ciliary dyskinesia.METHODS: The CLEAN-PCD trial was a phase 2, randomised, double-blind, placebo-controlled crossover tr...
Source: Respiratory Care - September 3, 2023 Category: Respiratory Medicine Authors: Felix C Ringshausen Adam J Shapiro Kim G Nielsen Henryk Mazurek Massimo Pifferi Karl H Donn Menno M van der Eerden Michael R Loebinger Maimoona A Zariwala Margaret W Leigh Michael R Knowles Thomas W Ferkol CLEAN-PCD investigators and study team Source Type: research
The antidepressant drugs vortioxetine and duloxetine differentially and sex-dependently affect animal well-being, cognitive performance, cardiac redox status and histology in a model of osteoarthritis
Biomed Pharmacother. 2023 Aug 30;166:115360. doi: 10.1016/j.biopha.2023.115360. Online ahead of print.ABSTRACTOsteoarthritis represents a leading cause of disability with limited treatment options. Furthermore, it is frequently accompanied by cardiovascular and cognitive disorders, which can be exacerbated by osteoarthritis or drugs used for its treatment. Here, we examined the behavioral and cardiac effects of the novel antidepressant vortioxetine in an osteoarthritis model, and compared them to duloxetine (an established osteoarthritis treatment). Osteoarthritis was induced in male and female rats with an intraarticular ...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - September 1, 2023 Category: Drugs & Pharmacology Authors: Katarina Nasti ć Uro š Pecikoza Milica Labudovi ć-Borović Jelena Kotur-Stevuljevi ć Ana Micov Aleksandar Jovanovi ć Maja Tomi ć Radica Stepanovi ć-Petrović Source Type: research
Repetitive and compulsive behavior after Early-Life-Pain associated with reduced long-chain sphingolipid species
CONCLUSION: The results suggest that ELP may predispose to chronic "pain" and compulsive psychopathology in part mediated by alterations of sphingolipid metabolism, which have been previously described in the context of addiction and psychiatric diseases.PMID:37635256 | DOI:10.1186/s13578-023-01106-3
Source: Cancer Control - August 27, 2023 Category: Cancer & Oncology Authors: Alexandra Vogel Timo Ueberbach Annett Wilken-Schmitz Lisa Hahnefeld Luisa Franck Marc-Philipp Weyer Tassilo Jungenitz Tobias Schmid Giulia Buchmann Florian Freudenberg Ralf P Brandes Robert Gurke Stephan W Schwarzacher Gerd Geisslinger Thomas Mittmann Irm Source Type: research
Non-CGRP Antagonist/Non-Triptan Options for Migraine Disease Treatment: Clinical Considerations
Curr Pain Headache Rep. 2023 Aug 16. doi: 10.1007/s11916-023-01151-0. Online ahead of print.ABSTRACTPURPOSE OF REVIEW: Although the association between CGRP and migraine disease is well-known and studied, therapies can target other pathways to minimize migraine symptoms. It is important to understand the role of these medications as options for migraine treatment and the varied mechanisms by which symptoms can be addressed. In the present investigation, the role of non-CGRP antagonist/non-triptan options for migraine disease therapy is reviewed, including NSAIDs, ß-blockers, calcium channel blockers, antidepressants, and ...
Source: Pain Physician - August 16, 2023 Category: Anesthesiology Authors: Ellen E Ingram Brooke E Bocklud Sarah C Corley Mallory A Granier Elisa E Neuchat Shahab Ahmadzadeh Sahar Shekoohi Alan D Kaye Source Type: research
