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Characterization of Eosinophilic Esophagitis in White Hispanic Children and Young Adults in South Florida
Eosinophilic Esophagitis (EoE) is a Th-2 mediated chronic disease of eosinophil infiltration of the esophageal mucosa, with a wide range of symptoms from mild GI pain to severe dysphagia and food impaction. EoE is increasing in developed countries throughout the world in varying populations.1 Prevalence studies of EoE among Hispanic/Latino populations from US and Spain/Latin America have shown conflicting results, with a wide range from 8.7 to 111.9 cases/100,000 people, respectively, with a median of 53.4/100,000.
Source: Annals of Allergy, Asthma and Immunology - March 20, 2023 Category: Allergy & Immunology Authors: Miguel J Lanz, Antonia C Rovira, Richard N Arboleda Source Type: research

Daily Clinical Practice in the Management of Chronic Urticaria in Spain: Results of the UCREX Study
CONCLUSIONS: Although most CU patients are treated with NS-H1AH, disease activity is still important, negatively affecting patients' QoL, work activity and healthcare resources use. An appropriate disease management could be the basis for symptoms control, QoL improvement and resources optimization.PMID:35249717 | DOI:10.1016/j.ad.2021.06.007
Source: Actas Dermo-Sifiliograficas - March 7, 2022 Category: Dermatology Authors: M Ferrer Puga J F Silvestre Salvador J Bartra Tomas A Gim énez-Arnau M Labrador-Horrillo J Miquel-Miquel F J Ortiz de Frutos J Sastre Dominguez A Valero Santiago P Terradas-Montana M Vidal-Jorge I J áuregui Presa Source Type: research

Johnson & Johnson Expands Phase 2a Clinical Trial of COVID-19 Vaccine Candidate to Include Adolescents
New Brunswick, NJ (April 2, 2021) – Johnson & Johnson (the Company) has begun vaccinating adolescent participants in the ongoing Phase 2a clinical trial for its COVID-19 vaccine candidate, developed by the Janssen Pharmaceutical Companies of Johnson & Johnson. “The COVID-19 pandemic has had a profound impact on adolescents, not just with the complications of the disease, but with their education, mental health, and wellbeing,” said Paul Stoffels, M.D., Vice Chairman of the Executive Committee and Chief Scientific Officer at Johnson & Johnson. “It is vital that we develop vaccines for everyone, everywher...
Source: Johnson and Johnson - April 2, 2021 Category: Pharmaceuticals Tags: Our Company Source Type: news

IJERPH, Vol. 17, Pages 594: Associations between Physical Activity and Comorbidities in People with COPD Residing in Spain: A Cross-Sectional Analysis
nchez There is a high prevalence of comorbidities among patients with chronic obstructive pulmonary disease (COPD). Comorbidities are likely common in patients with any COPD degree and are associated with increased mortality. The aim of this study was to determine the prevalence of thirty-one different COPD comorbidities and to evaluate the association between physical activity (PA) levels in people with COPD residing in Spain. Cross-sectional data from the Spanish National Health Survey 2017 were analysed. A total of 601 adults (52.2% females) with COPD aged 15 to 69 participated in this study. PA (exposure) was measu...
Source: International Journal of Environmental Research and Public Health - January 15, 2020 Category: Environmental Health Authors: S ánchez Castillo Smith D íaz Suárez L ópez Sánchez Tags: Article Source Type: research

New Trends in Migraine Pharmacology: Targeting Calcitonin Gene –Related Peptide (CGRP) With Monoclonal Antibodies
Conclusion Migraine is a disabling and debilitating neurovascular painful condition representing more than 90% of cases of recurrent headache and toward which the tendency can be inherited (MacGregor, 2017). Divalproex sodium, sodium valproate, topiramate, metoprolol, propranolol, and timolol have proven strong, level A, evidence for migraine prevention (American Academy of Neurology and American Headache Society, 2015). However, all the classic oral preventative treatments including tricyclic antidepressants, beta blockers, 5-HT2 antagonists ergots and anti-epileptic drugs were not developed for migraine and provide 50% ...
Source: Frontiers in Pharmacology - April 8, 2019 Category: Drugs & Pharmacology Source Type: research

Histamine and Delirium: Current Opinion
This study indicated that switch from H2 blockers to PPIs reduced delirium and, thus, providing an appropriate strategy to combat drug-induced delirium using antiulcer drugs (Fujii et al., 2012). The ventrolateral preoptic nucleus is a sleep-promoting nucleus located in the basal forebrain. A commonly used intravenous anesthetic, propofol, had been reported to induce sleep and augment the firing rate of neurons in ventrolateral GABAergic preoptic nucleus, but the underlining mechanism is yet to be clearly determined. Interestingly, the propofol-induced inhibition of inhibitory postsynaptic currents on noradrenalin-inhibite...
Source: Frontiers in Pharmacology - April 8, 2019 Category: Drugs & Pharmacology Source Type: research

Elemental Sulfur Use and Associations with Pediatric Lung Function and Respiratory Symptoms in an Agricultural Community (California, USA)
Conclusions: This study suggests that elemental sulfur use, allowed in both organic and conventional farming, in close proximity to residential areas, may adversely affect children’s respiratory health. https://doi.org/10.1289/EHP528 Received: 19 May 2016 Revised: 05 May 2017 Accepted: 09 May 2017 Published: 14 August 2017 Address correspondence to R. Raanan, Center for Environmental Research and Children’s Health (CERCH), University of California, Berkeley, School of Public Health, 1995 University Ave., Suite 265, Berkeley, CA 94704 USA. Telephone: (510) 642-9431. Email: rachelraananrr@gmail.com Supplemental Ma...
Source: EHP Research - August 14, 2017 Category: Environmental Health Authors: Daniil Lyalko Tags: Research Source Type: research