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Condition: Osteoporosis
Nutrition: Calcium
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Total 2097 results found since Jan 2013.
Molecular Complex of HSIM-loaded Polymeric Nanoparticles: Potential Carriers in Osteoporosis
CONCLUSION: Bone-targeting nanoparticles incorporating functionalized simvastatin can target bone. Thus, in order to distribute simvastatin subcutaneously for the treatment of osteoporosis, the developed nanoparticles may act as a promising approach.PMID:37718521 | DOI:10.2174/1389450124666230915092910
Source: Current Drug Targets - September 18, 2023 Category: Drugs & Pharmacology Authors: Malkiet Kaur Manju Nagpal Amarjot Kaur Grewal Samrat Chauhan Chander Parkash Dora Thakur Gurjeet Singh Source Type: research
Comparative effectiveness of therapeutic interventions in pregnancy and lactation-associated osteoporosis: a systematic review and meta-analysis
CONCLUSIONS: Due to high heterogeneity and lack of robust comparative data, no safe conclusions can be made regarding the optimal therapeutic intervention in women with PLO.PMID:37708365 | DOI:10.1210/clinem/dgad548
Source: The Journal of Clinical Endocrinology and Metabolism - September 14, 2023 Category: Endocrinology Authors: Panagiotis Anagnostis Kalliopi Lampropoulou-Adamidou Julia K Bosdou Georgios Trovas Petros Galanis Efstathios Chronopoulos Dimitrios G Goulis Symeon Tournis Source Type: research
Acyl-protein thioesterase1 alleviates senile osteoporosis by promoting osteoblast differentiation via depalmitoylation of BMPR1a
CONCLUSION: APT1 activated the BMP/Smad pathway and promoted OD by regulating BMPR1a depalmitoylation, thus alleviating mouse SOP.PMID:37674692 | PMC:PMC10477743 | DOI:10.1016/j.reth.2023.05.004
Source: Cancer Control - September 7, 2023 Category: Cancer & Oncology Authors: Changjiao Ji Qiaoyan Dong Huihui Liu Xiaodeng Yang Yingguang Han Bingrui Zhu Huaixin Xing Source Type: research
Tensin-3 is involved in osteogenic versus adipogenic fate of human bone marrow stromal cells
CONCLUSIONS: Here, we identify TNS3 to be involved in BMSC fate decision. Our study links the domain structure in TNS3 to RhoA activity via actin dynamics and implicates an important role for TNS3 in regulating osteogenesis and adipogenesis from BMSCs. Furthermore, it supports the critical involvement of cytoskeletal reorganization in BMSC differentiation.PMID:37668682 | PMC:PMC10480249 | DOI:10.1007/s00018-023-04930-5
Source: Cellular and Molecular Life Sciences : CMLS - September 5, 2023 Category: Cytology Authors: Shuang Zhang Jeroen van de Peppel Marijke Koedam Johannes P T M van Leeuwen Bram C J van der Eerden Source Type: research
Effect of chemotherapy and different chemotherapy regimens on bone health among Chinese breast cancer women in different menstrual status: a self-control study
CONCLUSION: Chemotherapy might induce lumbar vertebrae BMD loss and spine osteoporosis with regimen differences among Chinese BC patients. Calcium/VitD supplementation could improve bone turnover markers, bone metabolism indicators, and bone mineral density. Early interventions on bone health are needed for BC patients during chemotherapy.PMID:37642751 | DOI:10.1007/s00520-023-07960-8
Source: Cancer Control - August 29, 2023 Category: Cancer & Oncology Authors: Bai-Qing Peng Juan Wu Shen Tian Xiu-Quan Qu Xin-Yu Liang Jun-Han Feng Yu-Ling Chen Rui-Ling She Chen-Yu Ma Jing-Yu Song Zhao-Xing Li Zhi-Yu Jiang Kai-Nan Wu Ling-Quan Kong Source Type: research
The Association Between Bone Remodeling Markers, genes polymorphisms with Incidence of Osteopenia Among Young Saudi Female
In conclusion, the GG genotype of FDPS rs2297480 and the TT genotype of LRP5 rs3736228 was shown to be strongly associated with osteopenia in young Saudi females with low bone mineral density and SOST levels.PMID:37605583 | DOI:10.14715/cmb/2023.69.6.16
Source: Mol Biol Cell - August 22, 2023 Category: Molecular Biology Authors: Inass M Taha Azza M Abdu Allah Shereen El Tarhouny Intessar Sultan Omar Al Nozha Mayar M Elyyan Ghaidaa Elmehallawy Saad A S Aljohani Maha Desouky Rehab Abd Elfattah Mohamed Source Type: research
Mg-Zn-Ca Alloy (ZX00) Screws Are Resorbed at a Mean of 2.5 Years After Medial Malleolar Fracture Fixation: Follow-up of a First-in-humans Application and Insights From a Sheep Model
CONCLUSION: In this sheep model, Mg-alloy (ZX00) screws showed a resorption to one-third of the original volume after 25 months, without eliciting adverse immunologic reactions, supporting biocompatibility during this period. Mg-alloy (ZX00) implants were not detectable on radiographs after a mean of 2.5 years, suggesting full resorption, but further studies are needed to assess environmental changes regarding bone quality at the implantation site after implant resorption.CLINICAL RELEVANCE: The study demonstrated successful healing of medial malleolar fractures using bioresorbable Mg-alloy screws without clinical complica...
Source: Clinical Orthopaedics and Related Research - August 21, 2023 Category: Orthopaedics Authors: Viktor Labmayr Omer Suljevic Nicole Gabriele Sommer Uwe Yacine Schwarze Romy Linda Marek Iva Brcic Ines Foessl Andreas Leithner Franz Josef Seibert Valentin Herber Patrick Lukas Holweg Source Type: research
Dihydrotanshinone I attenuates estrogen-deficiency bone loss through RANKL-stimulated NF- κB, ERK and NFATc1 signaling pathways
In conclusion, our investigation elucidates the ability of DTI to regulate multiple signaling pathways activated by RANKL, leading to the inhibition of osteoclast formation and prevention of estrogen-deficiency osteoporosis. Consequently, DTI emerges as a promising candidate for the treatment of osteoporosis.PMID:37572501 | DOI:10.1016/j.intimp.2023.110572
Source: International Immunopharmacology - August 12, 2023 Category: Allergy & Immunology Authors: Chao Ma Liang Mo Zhangzheng Wang Deqiang Peng Chi Zhou Wei Niu Yuhao Liu Zhenqiu Chen Source Type: research
