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UCLA researchers provide first evidence of how obstructive sleep apnea damages the brain
Courtesy of Rajesh Kumar Brains with obstructive sleep apnea (left) and without UCLA researchers have reported the first evidence that obstructive sleep apnea contributes to a breakdown of the blood–brain barrier, which plays an important role in protecting brain tissue. The discovery, reported in the Sept. 1 issue of the Journal of Neuroimaging, could lead to new approaches for treating obstructive sleep apnea, which affects an estimated 22 million American adults. The disorder causes frequent interruptions in breathing during sleep because the airways narrow or become blocked. The blood–brain barrier limits harmful...
Source: UCLA Newsroom: Health Sciences - September 1, 2015 Category: Universities & Medical Training Source Type: news

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While pain is neither uncommon nor novel, the concept of central pain (CP) has only recently become a prominent concern in the medical literature. CP results from lesions to the central nervous system caused by conditions such as stroke, multiple sclerosis, epilepsy, Parkinson's disease, and brain and spinal cord injuries. With the incidence of disability from these conditions increasing dramatically worldwide, it is no surprise that the diagnosis and treatment of CP are of growing interest in the fields of pain management, neurology, neurosurgery, and anesthesiology. However, inconsistent and contradictory reporting has e...
Source: Journal of the Neurological Sciences - January 14, 2013 Category: Neurology Authors: Aimee L. Alphonso, Jack W. Tsao Tags: Book Reviews Source Type: research

157 E-Books New to JEFFLINE
Scott Library added these 157 e-books to the growing collection in May and June: Accurate Results in the Clinical Laboratory Adult Emergency Medicine Adult-Gerontology and Family Nurse Practitioner Certification Examination (4th ed.) Advanced Assessment: Interpreting Findings and Formulating Differential Diagnoses (2nd ed.) Advancing Your Career: Concepts of Professional Nursing (5th ed.) Arrhythmia Essentials Atlas of Advanced Operative Surgery Atlas of Clinical Neurology (3rd ed.) Atlas of Hematopathology: Morphology, Immunophenotype, Cytogenetics, and Molecular Approaches Atlas of Human Infectious Diseases Atlas of No...
Source: What's New on JEFFLINE - June 25, 2013 Category: Databases & Libraries Authors: Gary Kaplan Tags: All News Clinicians Researchers Students Teaching Faculty Source Type: news

Drugs used to treat joint and muscle disease
Publication date: Available online 19 February 2015 Source:Anaesthesia & Intensive Care Medicine Author(s): David G. Lambert Joint disease: Arthritis can be simply broken into osteoarthritis and rheumatoid arthritis (RA). Osteoarthritis is treated with symptomatic pain relief and surgery. RA is a chronic autoimmune disease that causes inflammation of joints (leading to their destruction), tissues around joints and other organ systems. Treatment (for pain) of RA in the first instance is with non-steroidal anti-inflammatory drugs, with second-line treatment using disease-modifying antirheumatic drugs (DMARDs). DMAR...
Source: Anaesthesia and intensive care medicine - February 24, 2015 Category: Anesthesiology Source Type: research

Ketamine Therapy for Treatment-resistant Depression in a Patient with Multiple Sclerosis: A Case Report
Conclusion—Ketamine may be an alternative treatment for resistant depression and may have a special use in patients with multiple sclerosis. Introduction Depression is a frequent finding in patients with multiple sclerosis (MS), with the lifetime prevalence rates for major depressive disorder (MDD) ranging from 36 to 54 percent, more than twice of that in the general population.[1] Even with advances in pharmacological options for treating depression, an estimated 33 to 66 percent of patients with MDD in the general population do not respond to the first antidepressant, and a reported 15 to 33 percent of patients do not ...
Source: Innovations in Clinical Neuroscience - February 1, 2017 Category: Neuroscience Authors: ICN Online Editor Tags: Case Report Current Issue Depression Multiple Sclerosis Neurology Psychiatry Psychopharmacology Electroconvulsive therapy Ketamine major depressive disorder treatment-resistant depression Source Type: research

AAPT Diagnostic Criteria for Central Neuropathic Pain
Central neuropathic pain, which is pain caused by a lesion or disease of the central somatosensory nervous system, is a serious consequence of spinal cord injury, stroke, multiple sclerosis and other conditions affecting the central nervous system. A collaborative effort between the Analgesic, Anesthetic, and Addiction Clinical Trial Translations, Innovations, Opportunities, and Networks (ACTTION) public-private partnership and the American Pain Society (APS), the ACTTION-APS Pain Taxonomy (AAPT) initiative, invited a working group to develop diagnostic criteria for central neuropathic pain.
Source: The Journal of Pain - June 27, 2017 Category: Materials Science Authors: Eva Widerstrom-Noga, John D. Loeser, Troels Staehelin Jensen, Nanna Brix Finnerup Source Type: research

Imaging of Blood-Brain Barrier Disruption by Tc-99m-Tilmanocept Molecular Imaging of a Rodent Model of Traumatic Brain Injury
Conclusions: These results are consistent with the hypothesis that microglial cells bearing CD206 trap fluorescent-labeled Tc-99m-tilmanocept in regions of BBB disruption. This provides the motivation for a clinical trial of intra-venously administered Tc-99m-tilmanocept with the goal of developing a SPECT/CT protocol for the detection of neuro-inflammation.
Source: Journal of Nuclear Medicine - May 23, 2018 Category: Nuclear Medicine Authors: Vera, D., Barback, C., Wang, S., Head, B., Hoh, C. Tags: Basic Science II Source Type: research

What is Ondine ’ s Curse?
Discussion Congenital central hypoventilation syndrome (CCHS) is an autosomal dominant with variable inheritance genetic disease caused by mutation in the Paired Like Homeobox B2 (PHOX2B) gene on chromosome 4. There are two other genes which may also cause CCHS. CCHS affects the chemoreceptor afferent ventilation pathways and is a neural crest migration problem of the autonomic nervous system. The incidence is unknown but a prevalence of 1 in 200,000 live births has been reported. Obviously it is a rarer phenomenon because of the general lethality of the syndrome. Patients usually present at birth or soon afterwards, but o...
Source: PediatricEducation.org - August 15, 2022 Category: Pediatrics Authors: Pediatric Education Tags: Uncategorized Source Type: news