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Plant-Derived Alkaloids: The Promising Disease-Modifying Agents for Inflammatory Bowel Disease
Conclusion This paper summarizes the current findings regarding the anti-colitis activity of plant-derived alkaloids and shows how these alkaloids exhibit significant and beneficial effects in alleviating colonic inflammation. These natural alkaloids are not only promising agents for IBD treatment but are also components for developing new wonder drugs. However, the underlying molecular mechanisms or toxicological evaluation of most plant-derived alkaloids still require much scientific research, and their actual efficacies for IBD patients have not been verified well in field research. Thus, further clinical trials to elu...
Source: Frontiers in Pharmacology - April 11, 2019 Category: Drugs & Pharmacology Source Type: research

Local infiltration anaesthesia versus sciatic nerve and adductor canal block for fast-track knee arthroplasty: A randomised controlled clinical trial
BACKGROUND Local infiltration anaesthesia (LIA) was introduced as an innovative analgesic procedure for enhanced recovery after primary total knee arthroplasty (TKA). However, LIA has never been compared with analgesia based on an adductor canal catheter and a single-shot sciatic nerve block. OBJECTIVE To evaluate two analgesic regimens for TKA comparing mobility, postoperative pain and patient satisfaction. DESIGN Two-group randomised, controlled clinical trial. SETTING Charité-Universitätsmedizin Berlin, Campus Charité Mitte, Germany between April and August 2017. PATIENTS Adults undergoing primary TKA u...
Source: European Journal of Anaesthesiology - March 4, 2019 Category: Anesthesiology Tags: Loco-regional anaesthesia Source Type: research

A Diagnostic Dilemma: Sometimes You ’ ll Never Know
Discussion It can be difficult to consider what is the problem when a health care provider is presented with a group of seemingly disparate signs and symptoms with a history and time course that do not match classic (or commonly atypical) disease presentations. Common things happen commonly, so when symptoms occur without the usual co-occurring symptoms, unusual symptoms or time courses, it can be challenging. The provider must develop a reasonable differential diagnosis and balance how far to go with the evaluation against how much to monitor the patient for new signs or symptoms which can provide new information. Patient...
Source: PediatricEducation.org - March 19, 2018 Category: Pediatrics Authors: pediatriceducationmin Tags: Uncategorized Source Type: news

Cll, a rare but treatable cause of longitudinally extensive myelitis
A 65-year-old lady presented with a 1-year history of progressive sensory and motor symptoms in the the legs, back pain, pruritus and night sweats. Neurological examination of the cranial nerves and upper limbs was unremarkable. Lower limb examination revealed mild bilateral spastic paraparesis. Cervical, axillary and inguinal lymphadenopathy was noted. Bloods showed only a mild lymphopenia. MRI revealed symmetrically diffuse nodular enhancement in the brain and longitudinally extensive transverse myelitis in the cervical and thoracic spine with leptomeningeal enhancement. CSF analysis showed a protein of 1888 mg/L, W...
Source: Journal of Neurology, Neurosurgery and Psychiatry - November 14, 2016 Category: Neurosurgery Authors: Ahmed, W., Coe, J., Carroll, L., Vundavalli, S., Chevassut, T., Saha, R. Tags: Immunology (including allergy), Cranial nerves, Infection (neurology), Multiple sclerosis, Pain (neurology), Spinal cord, Radiology, Surgical diagnostic tests, Radiology (diagnostics) ABN Annual Meeting, 17-19 May 2016, The Brighton Centre, Brighton Source Type: research

Read The Letter Hillary Clinton's Doctor Wrote About The Presidential Nominee's Health
Hillary Clinton’s doctor penned a letter Wednesday with more information about the Democratic presidential nominee’s health. The letter comes as Clinton recovers from a bout of pneumonia. Clinton’s physician, Dr. Lisa Bardack, said the presidential hopeful “is recovering well with antibiotics and rest.” Below, the full text of Dr. Bardack’s letter on Clinton’s health: This letter is a summary update on Hillary Rodham Clinton’s health since the release of my previous medical statement in July 2015. Mrs. Clinton has been seen by me regularly this year for routine car...
Source: Healthy Living - The Huffington Post - September 14, 2016 Category: Consumer Health News Source Type: news

Comparison of efficacy and safety of lateral-to-medial continuous transversus abdominis plane block with thoracic epidural analgesia in patients undergoing abdominal surgery: A randomised, open-label feasibility study
CONCLUSION: Continuous bilateral LM-TAP block can be initiated preoperatively and may provide comparable analgesia to TEA in patients undergoing laparotomy. CLINICAL TRIALS REGISTRY: not registered because registration was not mandatory at the time of starting the trial.
Source: European Journal of Anaesthesiology - October 3, 2015 Category: Anesthesiology Tags: Regional anaesthesia Source Type: research

Utility of iliac vein stenting in elderly population older than 80 years
Conclusions Iliac vein stenting appears to offer a safe and effective option in octogenarians and nonagenarians when compression fails, is difficult, or is impossible.
Source: Journal of Vascular Surgery: Venous and Lymphatic Disorders - May 8, 2015 Category: Surgery Source Type: research

“I’m Just In the Band”
Discussion Instrumental music, either as an avocation or profession, provides great pleasure for those performing and listening. Unfortunately it can also cause health problems. Many of the problems are musculoskeletal or neurological in etiology due to overuse and the musician may experience pain. Prelude to pain can include stiffness or tingling or other skin sensations. Musicians may experience weakness, loss of function, control (accuracy) and ability (speed) as well as problems with tone. “The most prevent problems involve overuse of muscles resulting from repetitive movements of playing, often in combination w...
Source: PediatricEducation.org - November 17, 2014 Category: Pediatrics Authors: pediatriceducationmin Tags: Uncategorized Source Type: news

Long-term Multimodal Therapy (Verapamil Associated with Propolis, Blueberry, Vitamin E and local Diclofenac) on Patients with Peyronie's Disease (Chronic Inflammation of the Tunica Albuginea ). Results of a Controlled Study.
CONCLUSION: Our results showed that a long-term multimodal medical therapy (Verapamil associated with Propolis, Blueberry, Vitamin E and local Diclofenac) is statistically effective in treating PD, whereas, lower therapeutic responses were obtained after 6 months treatment (medium-term treatment). Furthermore, this study strongly supports the recommendation that the best approach for treating PD is multimodal therapy. PMID: 24304332 [PubMed - as supplied by publisher]
Source: Inflammation and Allergy Drug Targets - December 4, 2013 Category: Allergy & Immunology Authors: Paulis G, Cavallini G, Giorgio GD, Quattrocchi S, Brancato T, Alvaro R Tags: Inflamm Allergy Drug Targets Source Type: research

A duodenal mass and acute pancreatitis.
In conclusion, the diagnosis of eosinophilic gastroenteritis should be considered in the patients with a duodenal mass. PMID: 24226730 [PubMed - in process]
Source: The Turkish Journal of Gastroenterology - June 1, 2013 Category: Gastroenterology Authors: Cakır OO, Bıyık M, Güngör G, Ataseven H, Demir A, Tavlı L Tags: Turk J Gastroenterol Source Type: research