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Specialty: Urology & Nephrology
Condition: Hypertension

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Total 232 results found since Jan 2013.

journal club
Takahashi et  al., on behalf of the American Heart Association Council on Cardiovascular Radiology and Intervention; Council on Hypertension; Council on the Kidney in Cardiovascular Disease; and Stroke Council. (Circulation. 2022;146:e558–e568.)
Source: Kidney International - March 20, 2023 Category: Urology & Nephrology Tags: Journal Club Source Type: research

Severe Neurological Involvement in an Adult with Shiga Toxin-Producing < i > Escherichia coli < /i > -Hemolytic Uremic Syndrome Treated with Eculizumab
A 68-year-old man with a medical history of hypertension was admitted to the emergency department for diffuse abdominal pain preceded by bloody diarrhea. Upon admission, neurological examination was normal, but he suddenly developed a left-sided hemiparesis. After a normal brain computed tomography, intravenous thrombolysis was administered for a suspicion of ischemic stroke. In the first laboratory investigations, hemoglobin was 16.9 g/dL, platelets 121 × 109/L (150 –450), and serum creatinine 1.17 mg/dL. By the second hospital day, the platelet level dropped to 79 × 109/L, with haptoglobin at 0.12 g/L, 3% schistocyte...
Source: Case Reports in Nephrology and Dialysis - January 27, 2023 Category: Urology & Nephrology Source Type: research

Valacyclovir-associated acute kidney injury and encephalopathy in an elderly woman with normal kidney function: a case report
AbstractA 72-year-old Japanese woman was treated by 3000  mg/day of valacyclovir for the herpes zoster in her left back. She had been treated as hypertension with no renal insufficiency. In two days, she visited an emergency room of a regional stroke care center with dysarthria, dexterity disorder and gait disturbance. Neither head CT nor MRI found intra cranial lesions, then, laboratory tests revealed that her serum creatinine level was 4.63 mg/dL. She was transferred and admitted to our hospital on the following day and received hemodialysis under the diagnosis of AKI due to acyclovir accompanied with encephalopathy. A...
Source: CEN Case Reports - November 18, 2022 Category: Urology & Nephrology Source Type: research

Should we liberalize potassium intake in CKD? No, we should not
Although a high dietary sodium (Na) intake has dominated our understanding of pathophysiology of hypertension, the moderating effects of a dietary potassium (K) intake on blood pressure (BP) are less appreciated. K depletion in normotensive men can increase BP,1 supplementation of K among normotensive women can modestly lower 24-hour ambulatory BP,2 and in those with untreated hypertension3 or among those with hypertension and hypokalemia provoked by diuretics, K supplementation can lower BP.4 A cluster randomized trial from 600 villages in China in people with a history of previous stroke (72.6%) or a history of hypertens...
Source: Kidney International - September 20, 2022 Category: Urology & Nephrology Authors: Rajiv Agarwal Tags: Controversies in Nephrology Source Type: research

Association of autosomal dominant polycystic kidney disease with cardiovascular disease: a US-National Inpatient Perspective
ConclusionsThe prevalence of CVD is high among patients with ADPKD, and the most important risk factor associated with CVD is severity of RD. We found an increase in the trend of hospitalizations of patients with ADPKD associated with increased risk of AF, PHN, NICM, and hemorrhagic stroke. History of CVD is the strongest predictor of mortality among patients with ADPKD.
Source: Clinical and Experimental Nephrology - February 25, 2022 Category: Urology & Nephrology Source Type: research

Mitochondrial deacetylase Sirt3 in vascular dysfunction and hypertension
Purpose of review Hypertension is a multifactorial disorder involving perturbations of the vasculature, the kidney, and the central nervous system. Hypertension represents a major risk factor for stroke, myocardial infarction, and heart failure. Despite treatment with multiple drugs, 37% of hypertensive patients remain hypertensive, likely due to the mechanisms contributing to blood pressure elevation that are not affected by current treatments. This review focuses on recently described novel role of mitochondrial deacetylase Sirt3 in vascular dysfunction and hypertension. Recent findings In the past several yea...
Source: Current Opinion in Nephrology and Hypertension - February 2, 2022 Category: Urology & Nephrology Tags: PATHOPHYSIOLOGY OF HYPERTENSION: Edited by Nancy J. Brown Source Type: research

APOL1 Risk Variants Associated with Serum Albumin in a Population-Based Cohort Study
CONCLUSION: APOL1 high-risk variants were associated with sALB. However, sALB did not statistically mediate the association between APOL1 and incident ESKD.PMID:35100591 | DOI:10.1159/000520997
Source: American Journal of Nephrology - January 31, 2022 Category: Urology & Nephrology Authors: Ninad S Chaudhary Hemant K Tiwari Bertha A Hidalgo Nita A Limdi Richard J Reynolds Mary Cushman Neil A Zakai Leslie Lange Suzanne E Judd Cheryl A Winkler Jeffrey B Kopp Orlando M Guti érrez Marguerite R Irvin Source Type: research

Association of peridialytic, intradialytic, scheduled interdialytic and ambulatory BP recordings with cardiovascular events in hemodialysis patients
CONCLUSIONS: Averaged intradialytic and scheduled home BP measurements (but not pre-dialysis readings) display similar prognostic associations with 44-h ambulatory BP in hemodialysis patients and represent valid metrics for hypertension management in these individuals.PMID:34988941 | DOI:10.1007/s40620-021-01205-9
Source: Journal of Nephrology - January 6, 2022 Category: Urology & Nephrology Authors: Fotini Iatridi Marieta P Theodorakopoulou Antonios Karpetas Athanasios Bikos Artemios G Karagiannidis Maria-Eleni Alexandrou Ioannis Tsouchnikas Christopher C Mayer Anna-Bettina Haidich Aikaterini Papagianni Gianfranco Parati Pantelis A Sarafidis Source Type: research

Novel approaches to hypoglycemia and burnt-out diabetes in chronic kidney disease
Purpose of review Diabetes mellitus is a leading cause of chronic kidney disease (CKD) that confers faster kidney disease progression, higher mortality, and various metabolic derangements including hypoglycemia. Recent findings Even in the absence of diabetes mellitus, growing research demonstrates that CKD patients are at heightened risk for hypoglycemia via multiple pathways. In CKD patients transitioning to end-stage renal disease (ESRD), spontaneous resolution of hyperglycemia and frequent hypoglycemia resulting in reduction and/or cessation of glucose-lowering medications are frequently observed in a phenom...
Source: Current Opinion in Nephrology and Hypertension - December 6, 2021 Category: Urology & Nephrology Tags: NOVEL THERAPEUTIC APPROACHES IN NEPHROLOGY AND HYPERTENSION: Edited by Ekamol Tantisattamo, Ramy M. Hanna and Kamyar Kalantar-Zadeh Source Type: research

Disparate Information Provided by Pulse Wave Velocity versus Other Measures of Aortic Compliance in End-Stage Renal Disease
Conclusion: In the absence of differences in PWV, higher aortic pulse pressure and characteristic impedance, and lower ratio of stroke index to aortic pulse pressure, suggest reduced aortic compliance and impaired left ventricular function in CKD patients. A lower subendocardial viability ratio predisposes the CKD patients to impaired cardiac oxygen supply versus hypertensive patients and nonmedicated controls.Nephron
Source: Nephron - September 6, 2021 Category: Urology & Nephrology Source Type: research

Stroke and Chronic Kidney Disease
Contrib Nephrol. 2021 Aug 3;199:1-11. doi: 10.1159/000517698. Online ahead of print.ABSTRACTChronic kidney disease (CKD) is strongly associated with the full spectrum of cerebrovascular disease including ischaemic and haemorrhagic stroke, small vessel disease, and vascular cognitive impairment. Shared conventional vascular risk factors such as age, hypertension, and diabetes mellitus may account for many of these associations, but novel renal-specific risk factors such as uraemia-related coagulopathy or endothelial dysfunction have also been proposed. In this chapter, we will explore the impact of CKD on stroke risk, mecha...
Source: Contributions to Nephrology - August 3, 2021 Category: Urology & Nephrology Authors: Dearbhla M Kelly Eoin M Kelleher Manish M Sood Source Type: research

Targeting TMEM16A-encoded Ca2+-activated Cl − channels: a new paradigm for antihypertensive therapy?
Hypertension is the leading risk factor for the development of heart diseases and stroke. Many hypertensive patients experience undesirable side effects to conventional antihypertensive pharmacotherapy. Cil et  al. documented the antihypertensive profile of a novel molecule, TMinh-23 (2-bromodifluoroacetylamino-5,6,7,8-tetrahydro-4H-cyclohepta[b]thiophene-3-carboxylic acid o-tolylamide), in the spontaneously hypertensive rat model of systemic hypertension. They showed that this agent reduces blood pressu re by inhibiting transmembrane member 16A–encoded calcium-activated chloride channels in vascular myocytes from resistance arteries.
Source: Kidney International - July 19, 2021 Category: Urology & Nephrology Authors: Normand Leblanc Tags: Commentary Source Type: research

Perioperative stroke and myocardial infarction in urologic surgery
CONCLUSIONS: Perioperative stroke and myocardial infarction were confirmed to be uncommon but devastating complications of urologic surgery, with incidence of 0.14% and 0.36%, respectively. Cystectomy was the highest risk urologic procedure. Perioperative stroke and myocardial infarction were strongly associated with age ≥ 70, hypertension, and disseminated cancer.PMID:34129461
Source: Canadian Journal of Urology - June 15, 2021 Category: Urology & Nephrology Authors: Da David Jiang Kyle A Gillis Yiyi Chen Jason C Hedges Nicholas H Chakiryan Source Type: research