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Specialty: Cardiology
Condition: Hypertension
Procedure: Perfusion

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Total 22 results found since Jan 2013.

Three Dimensional-Arterial Spin Labeling Evaluation of Improved Cerebral Perfusion After Limb Remote Ischemic Preconditioning in a Rat Model of Focal Ischemic Stroke
CONCLUSION: Three dimensional (3D) ASL can be used to evaluate LRP to improve stroke perfusion, and its protective effect may be closely related to LRP-induced vascular regeneration.PMID:35847828 | PMC:PMC9280338 | DOI:10.3389/fnana.2022.893953
Source: Atherosclerosis - July 18, 2022 Category: Cardiology Authors: Tianxiu Zheng Xiaolan Lai Jiaojiao Lu Qiuyan Chen Dingtai Wei Source Type: research

Modeling Superimposed Preeclampsia Using Ang II (Angiotensin II) Infusion in Pregnant Stroke-Prone Spontaneously Hypertensive RatsNovelty and Significance Preeclampsia
Hypertensive disorders of pregnancy are the second leading cause of maternal deaths worldwide. Superimposed preeclampsia is an increasingly common problem and often associated with impaired placental perfusion. Understanding the underlying mechanisms and developing treatment options are crucial. The pregnant stroke-prone spontaneously hypertensive rat has impaired uteroplacental blood flow and abnormal uterine artery remodeling. We used Ang II (angiotensin II) infusion in pregnant stroke-prone spontaneously hypertensive rats to mimic the increased cardiovascular stress associated with superimposed preeclampsia and examine ...
Source: Hypertension - June 13, 2018 Category: Cardiology Authors: Hannah L. Morgan, Elaine Butler, Shona Ritchie, Florian Herse, Ralf Dechend, Elisabeth Beattie, Martin W. McBride, Delyth Graham Tags: ACE/Angiotensin Receptors/Renin Angiotensin System, Animal Models of Human Disease, Hypertension, Preeclampsia Original Articles Source Type: research

Posterior Circulation Ischaemic Stroke
Am J Med Sci. 2022 Jan 29:S0002-9629(22)00030-1. doi: 10.1016/j.amjms.2021.10.027. Online ahead of print.ABSTRACTPosterior circulation ischaemic stroke (PCIS) is a disease of high burden. They account for 20-25% of all ischaemic strokes. However, it is relatively under-researched and requires more clinical attention, since it carries worse functional outcomes. Vertigo, visual disturbances and sensory/motor disturbances are found in PCIS. Large artery atherosclerosis and embolism are main causes of PCIS, while there is growing evidence that vertebrobasilar dolichoectasia is a key association. Hypertension is the commonest r...
Source: Atherosclerosis - February 1, 2022 Category: Cardiology Authors: Mr Alexander Ng Source Type: research

Sex-Related Differences in Patients Undergoing Thoracic Aortic Surgery: Evidence from the Canadian Thoracic Aortic Collaborative.
CONCLUSIONS: Women experience worse outcomes following thoracic aortic surgery with hypothermic circulatory arrest. Further investigation is required to better delineate which measures may reduce sex-related outcome differences following complex aortic surgery. PMID: 30755026 [PubMed - as supplied by publisher]
Source: Circulation - February 13, 2019 Category: Cardiology Authors: Chung J, Stevens LM, Ouzounian M, El-Hamamsy I, Bouhout I, Dagenais F, Cartier A, Peterson M, Boodhwani M, Guo MH, Bozinovski J, Yamashita MH, Lodewyks C, Atoui R, Bittira B, Payne D, Tarola C, Chu MWA, Canadian Thoracic Aortic Collaborative Tags: Circulation Source Type: research

Activation of Neuronal Transient Receptor Potential Vanilloid 1 Channel Underlies 20-Hydroxyeicosatetraenoic Acid-Induced Vasoactivity: Role for Protein Kinase A Inflammation and Hypertension
A rise in intraluminal pressure triggers vasoconstriction in resistance arteries, which is associated with local generation of the vasoconstrictor 20-hydroxyeicosatetraenoic acid (20-HETE). Importantly, dysregulation of 20-HETE synthesis and activity has been implicated in several cardiovascular disease states, including ischemic disease, hypertension, and stroke; however, the exact molecular pathways involved in mediating 20-HETE bioactivity are uncertain. We investigated whether 20-HETE activates the transient receptor potential vanilloid 1 (TRPV1) and thereby regulates vascular function and blood pressure. We demonstrat...
Source: Hypertension - July 17, 2013 Category: Cardiology Authors: Bubb, K. J., Wen, H., Panayiotou, C. M., Finsterbusch, M., Khan, F. J., Chan, M. V., Priestley, J. V., Baker, M. D., Ahluwalia, A. Tags: Animal models of human disease, Other Vascular biology Inflammation and Hypertension Source Type: research

Abstract 351: Mineralocorticoid Receptor Antagonism During the Development of Hypertension Improves Cerebral Artery Endothelium Dependent Dilation Even After Treatment Withdrawal Poster Session II
Hypertension causes cerebral artery remodeling and increases the risk of stroke. Renin angiotensin system blockade during the development of hypertension has therapeutic effects even after treatment withdrawal. Mineralocorticoid receptor (MR) activation has been implicated in artery remodeling and impaired endothelial function. The possibility that there is a critical therapeutic window for MR antagonism has not been investigated. We hypothesized that temporary MR antagonism while hypertension develops would improve endothelium dependent dilation even after treatment withdrawal. Six-week-old male stroke prone spontaneously...
Source: Hypertension - October 30, 2013 Category: Cardiology Authors: McClain, J. L., Dorrance, A. M. Tags: Poster Session II Source Type: research

Regulation of myogenic tone and structure of parenchymal arterioles by hypertension and the mineralocorticoid receptor
Proper perfusion is vital for maintenance of neuronal homeostasis and brain function. Changes in the function and structure of cerebral parenchymal arterioles (PAs) could impair blood flow regulation and increase the risk of cerebrovascular diseases, including dementia and stroke. Hypertension alters the structure and function of large cerebral arteries, but its effects on PAs remain unknown. We hypothesized that hypertension increases myogenic tone and induces inward remodeling in PAs; we further proposed that antihypertensive therapy or mineralocorticoid receptor (MR) blockade would reverse the effects of hypertension. P...
Source: AJP: Heart and Circulatory Physiology - July 1, 2015 Category: Cardiology Authors: Pires, P. W., Jackson, W. F., Dorrance, A. M. Tags: VASCULAR BIOLOGY AND MICROCIRCULATION Source Type: research

Effects of Riociguat on Right Ventricular Remodelling in Chronic Thromboembolic Pulmonary Hypertension Patients: A Prospective Study
ConclusionsRiociguat treatment was associated with increased RV stroke volume index and trends for improvement in myocardial remodelling in patients with CTEPH. A larger clinical study is warranted to observe the therapeutic benefits of riociguat on RV remodelling.RésuméContexteLes effets du traitement par le riociguat sur le métabolisme, la perfusion et le débit du ventricule droit (VD) chez les patients atteints d’hypertension pulmonaire thromboembolique chronique (HPTC) sont inconnus. Dans la présente étude, nous analysons les changements aux ventriculaires droits associés au traitement par le riociguat.Méthod...
Source: Canadian Journal of Cardiology - August 29, 2018 Category: Cardiology Source Type: research

Incidence and Distribution of Cerebral Embolism After Cardiac Surgery According to the Systemic Perfusion Strategy 　- A Diffusion-Weighted Magnetic Resonance Imaging Study.
CONCLUSIONS: According to the results of postoperative DW-MRI, retrograde perfusion itself might not increase the incidence of postoperative cerebral embolism in properly selected cardiac surgery patients undergoing routine preoperative CTA examination. PMID: 31776305 [PubMed - as supplied by publisher]
Source: Circulation Journal - November 25, 2019 Category: Cardiology Authors: Je HG, Ju MH, Lee CH, Lim MH, Lee JH, Oh HR Tags: Circ J Source Type: research

Older adults with higher blood pressure variability exhibit cerebrovascular reactivity deficits
CONCLUSIONS: Findings add to prior work linking blood pressure variability and cerebrovascular disease burden and suggest blood pressure variability may also be related to prodromal markers of cerebrovascular dysfunction and disease, with potential therapeutic implications.PMID:36149821 | DOI:10.1093/ajh/hpac108
Source: American Journal of Hypertension - September 23, 2022 Category: Cardiology Authors: Isabel J Sible Jung Yun Jang Shubir Dutt Belinda Yew John Paul M Alitin Yanrong Li Anna E Blanken Jean K Ho Anisa J Marshall Arunima Kapoor Fatemah Shenasa Aim ée Gaubert Amy Nguyen Virginia E Sturm Mara Mather Kathleen E Rodgers Xingfeng Shao Danny J Wa Source Type: research

Abstract P015: Bilateral Common Carotid Artery Stenosis in Hypertensive Rats Impairs Dilation in Penetrating Arterioles and Posterior Communicating Arteries Session Title: Poster Session 1- Trainee Onsite Poster Competition and Reception
Hypertension and chronic cerebral hypoperfusion (CCH) are leading risk factors for cognitive impairment. We induced hypoperfusion in stroke prone spontaneously hypertensive rats (SHRSP) by bilateral carotid artery stenosis (BCAS) to create a novel, physiologically relevant model of cognitive impairment. We hypothesized that BCAS in SHRSP would impair endothelium dependent dilation and lead to outward remodeling of the penetrating arterioles (PAs) and posterior cerebral arteries (PCAs). The PAs are critical for maintaining parenchymal perfusion and controlling blood flow to the neurovascular unit, and the PCAs are integral ...
Source: Hypertension - November 3, 2015 Category: Cardiology Authors: Matin, N., Fisher, C., Jackson, W. F., Dorrance, A. M. Tags: Session Title: Poster Session 1- Trainee Onsite Poster Competition and Reception Source Type: research

A new variation of dual left anterior descending coronary artery
We report a new variation of dual LAD which has not been reported previously and coronary computed tomography angiography helped to characterize this anomaly. Our case further expands anatomical variations of dual LADs.>
Source: Journal of Cardiology Cases - March 30, 2016 Category: Cardiology Source Type: research

Abstract 031: Diastolic Blood Pressure, Coronary Artery Calcium, and Cardiac Outcomes in the Multi-ethnic Study of Atherosclerosis Session Title: Cardiac Hypertrophy and Dysfunction
Diastolic blood pressure (BP) has a J-curve relationship with coronary heart disease and death. Because this association is thought to reflect reduced coronary perfusion at low diastolic BP, our objective was to test whether the J-curve is most pronounced among persons with coronary artery calcium. Among 6,811 participants from the Multi-Ethnic Study of Atherosclerosis, we used Cox models to examine if diastolic BP category is associated with coronary heart disease events, stroke, and mortality. Analyses were conducted in the sample overall and after stratification by coronary artery calcium score. In multivariable-adjuste...
Source: Hypertension - September 14, 2017 Category: Cardiology Authors: John W McEvoy, Faisal Rahman, Mahmoud Al Rifai, Michael Blaha, Khurram Nasir, Matthew Budoff, Bruce Psaty, Wendy Post, Roger Blumenthal Tags: Oral Abstract Presentations Source Type: research

Abstract P136: Ischemic Evaluation in Patients With Hypertensive Emergency / Urgency and Acute Systolic Heart Failure: Is Coronary Angiography Required for All? Session Title: Onsite Poster Competition I With Reception
Conclusions: Our results suggest that only a minority of patients with HU/E and S-HF have obstructive CAD. It may be possible to stratify patients using demographic and non-invasive tests to direct only those with high likelihood of O-CAD for coronary angiography. These results should be validated in large registry populations.
Source: Hypertension - September 14, 2017 Category: Cardiology Authors: Jared W Davis, Muhannad Almubarak, Samuel K McElwee, Amrita Mukherjee, Firas Al-Solaiman, Mark F Sasse, Massoud A Leesar, Arka Chatterjee Tags: Poster Abstract Presentations Source Type: research