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This year's top 10 advances in cardiovascular disease
Progress in the fight against heart disease and stroke came on many fronts during 2014, from novel drugs and procedures to improvements and newfound benefits from existing treatments. In the December 2014 Harvard Heart Letter, Editor in Chief Dr. Deepak L. Bhatt selected 10 of the most important advances. New drugs cut cholesterol levels by half. A new class of drugs, given by injection just once or twice a month, can slash harmful LDL cholesterol levels by about 50%. Studies are under way to see if any of these experimental agents, called PCSK9 inhibitors, prevent heart attacks or improve heart disease survival. Replacing...
Source: New Harvard Health Information - November 24, 2014 Category: Consumer Health News Source Type: news

The spectrum of low-output low-gradient aortic stenosis with normal ejection fraction
Low-flow, low-gradient (LF/LG) severe aortic stenosis (AS) with preserved ejection fraction refers to the condition of AS with aortic valve area ≤1 cm2, stroke volume index <35 mL/m2, mean aortic valve gradient <40 mm Hg and left ventricular ejection fraction ≥50%. This mismatch of aortic valve area suggesting severe stenosis and ‘low’ gradient in some patients has led to confusion as to the severity of stenosis. Conditions previously labelled as LF/LG severe AS include a spectrum, with measurement error probably being the most common cause of marked inconsistency between gradien...
Source: Heart - April 11, 2016 Category: Cardiology Authors: Pislaru, S. V., Pellikka, P. A. Tags: Review articles Reviews Source Type: research

Aortic Valve Replacement in the Moderately Elevated Risk Patient: A Population-Based Analysis of Outcomes
Conclusions This population-based contemporary assessment suggests moderate-risk patients undergoing AVR experience favorable outcomes. Although increasing PROM is important in preoperative evaluation of risk, preexisting pulmonary hypertension and indication for operation are among other factors that should be considered as TAVR expands into this group of patients.
Source: The Annals of Thoracic Surgery - June 17, 2016 Category: Cardiovascular & Thoracic Surgery Source Type: research

Aortic Valve Replacement in the Moderately Elevated Risk Patient: A Population-Based Analysis of Outcomes.
CONCLUSIONS: This population-based contemporary assessment suggests moderate-risk patients undergoing AVR experience favorable outcomes. Although increasing PROM is important in preoperative evaluation of risk, preexisting pulmonary hypertension and indication for operation are among other factors that should be considered as TAVR expands into this group of patients. PMID: 27324524 [PubMed - as supplied by publisher]
Source: The Annals of Thoracic Surgery - June 17, 2016 Category: Cardiovascular & Thoracic Surgery Authors: Patel HJ, Likosky DS, Pruitt AL, Murphy ET, Theurer PF, Prager RL Tags: Ann Thorac Surg Source Type: research

Safety and Feasibility of Treatment with Rivaroxaban for Non-Canonical Indications: A Case Series Analysis
Conclusions Rivaroxaban is a valuable treatment option for patients with biological prostheses, repaired mitral valves, or a tubular aortic graft in order to prevent thromboembolic complications.
Source: Clinical Drug Investigation - July 10, 2016 Category: Drugs & Pharmacology Source Type: research

Impact of health utility after thrombotic complications following total hip and knee arthroplasty
ConclusionObjective calculation of both the benefit and risks of anticoagulation in the post‐operative patient is significantly altered by including the effect on patient's quality of life utility value. Therapeutic anticoagulation in some common situations is probable to be of more detriment than benefit when considering health utility.
Source: ANZ Journal of Surgery - July 31, 2017 Category: Surgery Authors: Bikram Karmakar Tags: Original Article Source Type: research

Preventable Cases of Oral Anticoagulant-Induced Bleeding: Data From the Spontaneous Reporting System
Conclusion: Our findings describe the most reported risk factors for preventability of oral anticoagulant-induced bleedings. These factors may be useful for targeting interventions to improve pharmacovigilance activities in our regional territory and to reduce the burden of medication errors and inappropriate prescription. Introduction Oral anticoagulant therapy is widely used for the prevention of stroke and systemic embolism in patients with atrial fibrillation, or for the prevention and treatment of deep vein thrombosis and pulmonary embolism (Raj et al., 1994; Monaco et al., 2017). Oral anticoagulants can be di...
Source: Frontiers in Pharmacology - April 29, 2019 Category: Drugs & Pharmacology Source Type: research

Almanac 2013: Novel non-coronary cardiac interventions
Recent innovations in interventional cardiology have dramatically expanded the therapeutic options for patients with cardiac conditions. Interventional cardiology is no longer limited to the treatment of coronary artery disease but allows also treatment of valvular disease, stroke prevention, hypertension, etc. One of the most important new treatment options is the percutaneous treatment for aortic valve stenosis (transcatheter aortic valve implantation), since aortic valve disease is a rather common problem in elderly patients, with many of them at high risk for surgery. Similarly, mitral regurgitation is often associated...
Source: Heart - August 15, 2013 Category: Cardiology Authors: Meier, P., Franzen, O., Lansky, A. J. Tags: Drugs: cardiovascular system, Hypertension, Interventional cardiology, Aortic valve disease, Mitral valve disease Almanac 2013 Source Type: research

Systemic Hypertension in Low Gradient Severe Aortic Stenosis with Preserved Ejection Fraction.
CONCLUSIONS: Systemic hypertension in LG severe AS with preserved EF is associated with elevated LV filling pressures and pulmonary hypertension. Treatment of hypertension with vasodilator therapy results in a lowering of the total LV afterload, with a decrease in LV filling pressures and pulmonary artery pressures. These findings have important implications for the management of patients with LG severe AS with preserved EF and hypertension. PMID: 23956211 [PubMed - as supplied by publisher]
Source: Circulation - August 16, 2013 Category: Cardiology Authors: Eleid MF, Nishimura RA, Sorajja P, Borlaug BA Tags: Circulation Source Type: research

065 * a propensity-matched analysis of outcomes and long-term survival in stented versus stentless valves for aortic valve replacement
Conclusions: Stentless and stented valves had identical 30-day outcomes except for a higher incidence of postoperative bleeding in the stented group. There was no significant difference in long-term survival between stented and stentless valves in this large cohort. Both valves may be used for AVR with low morbidity and excellent long-term survival.
Source: Interactive CardioVascular and Thoracic Surgery - September 18, 2013 Category: Cardiovascular & Thoracic Surgery Authors: Shultz, B., Timek, T. A., Davis, A. T., Heiser, J. C., Murphy, E. T., Patzelt, L. H., Willekes, C. L., Hooker, R. L. Tags: Aortic valve replacement: Long-term outcomes Source Type: research

138 * transapical aortic valve implantation in patients with and without severe calcification of the ascending aorta: different preoperative characteristics but no difference in outcome
Conclusions: In contrast to conventional aortic valve replacement, severe calcification of the ascending aorta has no negative influence on perioperative outcome and long-term survival after transapical TAVI.
Source: Interactive CardioVascular and Thoracic Surgery - September 18, 2013 Category: Cardiovascular & Thoracic Surgery Authors: Buz, S., Pasic, M., Drews, T., Dreysse, S., Kukucka, M., Mladenow, A., Hetzer, R., Unbehaun, A. Tags: Transcatheter aortic valve implantation: Expanding indications and techniques Source Type: research

275 * early prosthetic valve degeneration with mitroflow aortic valves: determination of incidence and risk factors
Conclusions: There is an unexplained incidence (3.6%) of early valve degeneration resulting in explantation in some patients at two years after surgery. Mitroflow valves may not be suited to a younger age population.
Source: Interactive CardioVascular and Thoracic Surgery - September 18, 2013 Category: Cardiovascular & Thoracic Surgery Authors: Joshi, V., Prosser, K., Richens, D. Tags: Complex aortic valve surgery Source Type: research

Almanac 2013: novel non-coronary cardiac interventions.
Abstract Recent innovations in interventional cardiology have dramatically expanded the therapeutic options for patients with cardiac conditions. Interventional cardiology is no longer limited to the treatment of coronary artery disease but allows also treatment of valvular disease, stroke prevention, hypertension, etc. One of the most important new treatment options is the percutaneous treatment for aortic valve stenosis (transcatheter aortic valve implantation), since aortic valve disease is a rather common problem in elderly patients, with many of them at high risk for surgery. Similarly, mitral regurgitation i...
Source: The Anatolian Journal of Cardiology - September 10, 2013 Category: Cardiology Authors: Meier P, Franzen O, Lansky AJ Tags: Anadolu Kardiyol Derg Source Type: research

Continuous Flow Left Ventricular Assist Device Implant Significantly Improves Pulmonary Hypertension, Right Ventricular Contractility, and Tricuspid Valve Competence
ConclusionContinuous flow LVAD implant improves pulmonary hypertension, RV function, and tricuspid regurgitation. TR may be managed nonoperatively during CF LVAD implant.
Source: Journal of Cardiac Surgery - September 30, 2013 Category: Cardiovascular & Thoracic Surgery Authors: Pavan Atluri, Alexander S. Fairman, John W. MacArthur, Andrew B. Goldstone, Jeffrey E. Cohen, Jessica L. Howard, Christyna M. Zalewski, Yasuhiro Shudo, Y. Joseph Woo Tags: Original Article Source Type: research

Almanac 2013: novel non-coronary cardiac interventions.
Abstract Recent innovations in interventional cardiology have dramatically expanded the therapeutic options for patients with cardiac conditions. Interventional cardiology is no longer limited to the treatment of coronary artery disease but allows also treatment of valvular disease, stroke prevention, hypertension, etc. One of the most important new treatment options is the percutaneous treatment for aortic valve stenosis (transcatheter aortic valve implantation), since aortic valve disease is a rather common problem in elderly patients, with many of them at high risk for surgery. Similarly, mitral regurgitation i...
Source: Wiener Klinische Wochenschrift - December 14, 2013 Category: Journals (General) Authors: Meier P, Franzen O, Lansky AJ Tags: Wien Klin Wochenschr Source Type: research

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