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Condition: Hypertension
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Total 427 results found since Jan 2013.

Spontaneous white matter lesion in brain of stroke-prone renovascular hypertensive rats: a study from MRI, pathology and behavior
This study aimed to investigate the WML in RHRSP from MRI, pathology and behavior. RHRSP model was established by two-kidney, two-clipmethod and kept for 20 weeks. WML was decteted by magnetic resonance imaging (MRI) and loyez staining. Cognition was tested by morris water maze (MWM). Vascular changes were observed by HE staining on brain and carotid sections. Ultrastucture of blood brain barrier (BBB) were observed by transmission electron microscope. Immunofluorescence was used to detect albumin leakage and cell proliferation. T2-weighted MRI scans of RHRSP displayed diffuse, confluent white-matter hyperintensities. Pat...
Source: Metabolic Brain Disease - November 11, 2015 Category: Neurology Source Type: research

Impaired renal function is related to deep and mixed, but not strictly lobar cerebral microbleeds in patients with ischaemic stroke and TIA
Abstract The vasculature of the brain and kidneys are similarly vulnerable to hypertension, so their microvascular damage may be correlated. We investigated the relationship of renal function to the anatomical distribution of cerebral microbleeds (CMBs), a marker of underlying cerebral small vessel disease (hypertensive arteriopathy or cerebral amyloid angiopathy), in a Western patient cohort. This was a retrospective study of referrals to a hospital stroke service. All patients with clinical data and a T2*-weighted gradient-recalled echo (T2*-GRE) MRI were included. MRI scans were rated for CMBs using the Microbl...
Source: Journal of Neurology - February 17, 2016 Category: Neurology Source Type: research

Significance of Hematoma Shape and Density in Intracerebral Hemorrhage: The Intensive Blood Pressure Reduction in Acute Intracerebral Hemorrhage Trial Study Clinical Sciences
Conclusions— Irregular shape, but not heterogeneous density, is independently associated with poor outcome after ICH. Clinical Trial Registration— URL: http://www.clinicaltrials.gov. Unique identifier: NCT00716079.
Source: Stroke - April 24, 2016 Category: Neurology Authors: Delcourt, C., Zhang, S., Arima, H., Sato, S., Salman, R. A.-S., Wang, X., Davies, L., Stapf, C., Robinson, T., Lavados, P. M., Chalmers, J., Heeley, E., Liu, M., Lindley, R. I., Anderson, C. S., for the INTERACT2 investigators Tags: Hypertension, Computerized Tomography (CT), Mortality/Survival, Cerebrovascular Disease/Stroke, Intracranial Hemorrhage Clinical Sciences Source Type: research

Teaching NeuroImages: Acute isolated oculomotor nerve palsy of microvascular origin
A 73-year-old man presented with acute-onset, right-sided ptosis and pain above the right eye. His medical history noted hypertension and diabetes. On physical examination, an isolated right oculomotor palsy was noted with preserved pupillary function. An MRI scan revealed isolated swelling of superior, inferior, and medial rectus muscle at the right side (figure). No cause other than presumed microvascular oculomotor nerve ischemia was shown.1 In patients aged 50 years or older, isolated ocular motor nerve palsies are most likely due to microvascular ischemia, but other etiologies such as aneurysm, brainstem stroke, and m...
Source: Neurology - August 14, 2016 Category: Neurology Authors: van den Wijngaard, I. R., Hagenbeek, R. E., Jellema, K., Lycklama a Nijeholt, G. J. Tags: MRI, Other cerebrovascular disease/ Stroke, All Clinical Neurology, Ocular motility RESIDENT AND FELLOW SECTION Source Type: research

Prognostic significance of delayed intraventricular haemorrhage in the INTERACT studies
Conclusions Although linked to factors determining greater ICH growth including poor SBP control, dIVH is independently associated with poor outcome in acute small to moderate-size ICH. Trial registration numbers NCT00226096 and NCT00716079.
Source: Journal of Neurology, Neurosurgery and Psychiatry - December 14, 2016 Category: Neurosurgery Authors: Moullaali, T. J., Sato, S., Wang, X., Rabinstein, A. A., Arima, H., Carcel, C., Chen, G., Robinson, T., Heeley, E., Chan, E., Delcourt, C., Stapf, C., Cordonnier, C., Lindley, R. I., Chalmers, J., Anderson, C. S., for the INTERACT Investigators Tags: Stroke, Hypertension Cerebrovascular disease Source Type: research

Lipid Changes Around the Final Menstrual Period Predict Carotid Subclinical Disease in Postmenopausal Women Clinical Sciences
Conclusions—Changes in lipids as women approach the FMP provide useful clinical information for understanding postmenopausal carotid indices.
Source: Stroke - December 22, 2016 Category: Neurology Authors: Karen A. Matthews, Samar R. El Khoudary, Maria M. Brooks, Carol A. Derby, Sioban D. Harlow, Emma J.M. Barinas–Mitchell, Rebecca C. Thurston Tags: Epidemiology, Women, Atherosclerosis, Coronary Artery Disease Original Contributions Source Type: research

Ischemic stroke and intracranial hemorrhage in patients with recurrent glioblastoma multiforme, treated with bevacizumab
AbstractBevacizumab (BVZ), a monoclonal antibody directed against vascular endothelial growth factor (VEGF), has been suspected to increase the incidence of ischemic stroke (IS) and intracranial hemorrhage (ICH) in GBM patients. Intracranial vascular events, such as IS and ICH, were retrospectively analyzed in 364 MRI scans of 82 patients with recurrent GBM (1st/2nd/3rd relapse). Out of these 82 patients, 40 were treated with BVZ (178 scans) in addition to basic treatment, whereas 42 patients matching for age and gender received basic treatment (186 scans). Distribution of typical vascular risk factors between both groups ...
Source: Journal of Neuro-Oncology - May 29, 2017 Category: Cancer & Oncology Source Type: research

Neuroimaging Correlates of Cerebral Microbleeds Clinical Sciences
Conclusions—CMBs are a common vascular pathology in the elderly. Markers of hypertensive small-vessel disease may contribute to deep CMBs while cerebral amyloid angiopathy may drive development of lobar CMBs.
Source: Stroke - October 23, 2017 Category: Neurology Authors: Jonathan Graff-Radford, Jeannette Simino, Kejal Kantarci, Thomas H. Mosley Jr, Michael E. Griswold, B. Gwen Windham, A. Richey Sharrett, Marilyn S. Albert, Rebecca F. Gottesman, Clifford R. Jack Jr, Prashanthi Vemuri, David S. Knopman Tags: Magnetic Resonance Imaging (MRI), Cerebrovascular Disease/Stroke, Atherosclerosis Original Contributions Source Type: research

Induced Hypertension for Delayed Cerebral Ischemia After Aneurysmal Subarachnoid Hemorrhage Clinical Sciences
Conclusions—Before this trial, the effectiveness of induced hypertension for DCI in aneurysmal subarachnoid hemorrhage patients was unknown because current literature consists only of uncontrolled case series. The results from our premature halted trial do not add any evidence to support induced hypertension and show that this treatment can lead to serious adverse events.Clinical Trial Registration—URL: http://www.clinicaltrials.gov. Unique identifier: NCT01613235.
Source: Stroke - December 22, 2017 Category: Neurology Authors: Celine S. Gathier, Walter M. van den Bergh, Mathieu van der Jagt, Bon H. Verweiȷ, Jan Willem Dankbaar, Marcella C. Muller, Annemarie W. Oldenbeuving, Gabriel J.E. Rinkel, Arȷen J.C. Slooter, for the HIMALAIA Study Group* Tags: Treatment, Quality and Outcomes, Cerebrovascular Disease/Stroke Original Contributions Source Type: research

Prehospital Systolic Blood Pressure Is Related to Intracerebral Hemorrhage Volume on Admission Brief Report
Background and Purpose—Ultra-early blood pressure (BP) management in the prehospital setting could improve the efficacy of this treatment on attenuating intracerebral hemorrhage (ICH) expansion. We aimed to determine the association of prehospital systolic BP (SBP) with ICH volume, ultra-early hematoma growth, and the spot sign on admission.Methods—We conducted a retrospective study of a prospective database of 219 consecutive patients with spontaneous ICH admitted to the emergency department of a tertiary stroke center during a 3-year period. Prehospital SBP and ICH volume, ultra-early hematoma growth (ICH volume/onse...
Source: Stroke - December 22, 2017 Category: Neurology Authors: David Rodriguez–Luna, Noelia Rodriguez–Villatoro, Jesus M. Juega, Sandra Boned, Marian Muchada, Estela Sanȷuan, Jorge Pagola, Marta Rubiera, Marc Ribo, Pilar Coscoȷuela, Carlos A. Molina Tags: High Blood Pressure, Computerized Tomography (CT), Intracranial Hemorrhage Brief Reports Source Type: research

Otitis Media Leads to Brain Abscess Presenting as Stroke
By Mikhail Elfond, DO; Esi Quayson, MD; & Joseph V.M. Kelly, MD, MBA A 65-year-old man presented to the ED via EMS with symptoms of stroke. The paramedics stated his right-sided weakness and speech difficulty started 40 minutes prior to presentation in the ED. En route to the hospital, paramedics observed four episodes of facial twitching.       Vitals signs were significant for a rectal temperature of 100.2°F and a fingerstick blood sugar of 220 mg/dL. History of present illness was significant for a diagnosis of left otitis media treated with Augmentin and Vicodin at an urgent care center ...
Source: The Case Files - January 20, 2015 Category: Emergency Medicine Tags: Blog Posts Source Type: research

Letter to the Editor: Pneumocephalus: Is the needle size significant?
Discussion. Pneumocephalus is defined by two mechanisms: a ball-valve and an inverted bottle concept.1 The ball-valve type implies positive pressure events, such as coughing or valsalva maneuvers, that prevent air escape. Tension pneumocephalus is included in this mechanism, causing a parenchymal mass effect. The inverted bottle theory includes a negative intracranial pressure gradient following cerebrospinal fluid drainage, relieved by air influx. A small pneumocephalus is usually sealed by blood clots or granulation, allowing spontaneous reabsorption and resolution.[1] Otherwise, the lateral positioning of a patient duri...
Source: Innovations in Clinical Neuroscience - February 1, 2018 Category: Neuroscience Authors: ICN Online Editor Tags: Assessment Tools CNS Infections Current Issue Letters to the Editor Neurologic Systems and Symptoms Neurology Stroke Traumatic Brain Injury epidural needle size Pneumocephalus spinal tap Source Type: research

Haemorrhagic stroke related to the use of 4-fluoroamphetamine
We report on two patients who presented with headache and mild hypertension after 4-FA use. Patient A developed one-sided weakness and decreased consciousness after a few hours. A computed tomography scan showed a left-sided intracerebral haemorrhage. Because of life-threatening cerebral herniation, haematoma evacuation was performed. Postoperatively, she suffered from a right-sided hemiparalysis and severe aphasia, requiring clinical rehabilitation. Patient B had a subarachnoid haemorrhage without neurological deficits. In total, 939 4-FA-intoxicated patients were registered. These patients used 4-FA alone (44%) or in com...
Source: Journal of Neurology - May 8, 2018 Category: Neurology Source Type: research

Ipsilateral Vocal Cord Paralysis After Acute Anterior Ischemic Stroke
CONCLUSION: Our case is a rare case of transient ipsilateral vocal cord paralysis associated with anterior unilateral cerebral ischemia. The paralysis resolved with improvement of the cerebral ischemic penumbra.PMID:33635769 | DOI:10.7812/TPP/20.104
Source: The Permanente journal - February 26, 2021 Category: General Medicine Authors: Khalid Sawalha Ahmed Abd Elazim Omar Hussein Source Type: research