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Condition: Hypertension

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Total 36 results found since Jan 2013.

Sex differences in outcomes after stroke among patients with low total cholesterol levels: a large hospital-based prospective study
ConclusionsThese findings suggest that patients (both men and women) with atherothrombotic infarction who have low TC levels would not benefit from receiving statin treatment. Therefore, it is crucial to explore the impact of statin treatment on outcomes in Asian patients, especially Chinese patients with atherothrombotic and low TC levels, in order to improve outcomes after stroke and reduce the disease burden.
Source: Biology of Sex Differences - November 23, 2016 Category: Biology Source Type: research

Sex differences in long-term outcomes among acute ischemic stroke patients with diabetes in China
Conclusions These findings suggest that it is crucial to establish the individual scheme of therapy for every patient by different risk factors of stroke, strengthen the rehabilitation of stroke, and carry on the health education early for the secondary prevention of stroke in patients with diabetes mellitus (DM).
Source: Biology of Sex Differences - December 4, 2015 Category: Biology Source Type: research

Sex differences in the association between diabetes and hypertension and the risk of stroke: cohort of the Tehran Lipid and Glucose Study
ConclusionHypertension and T2D induced higher risk of overall and ischemic stroke in men than women among Iranian population.
Source: Biology of Sex Differences - March 15, 2022 Category: Biology Source Type: research

A study on the association of rs7950273 polymorphism in the PDGFD with ischaemic stroke in the Chinese Han population.
CONCLUSION: This study suggests that the polymorphism of rs7950273 in the PDGFD gene is not associated with ischaemic stroke in the Chinese Han population. Further studies on the gene-gene and gene-environment interactions for the PDGFD gene and ischaemic stroke are needed. PMID: 26362023 [PubMed - in process]
Source: Annals of Human Biology - February 13, 2016 Category: Biology Tags: Ann Hum Biol Source Type: research

Transplantation of bone marrow mesenchymal stem cells decreases oxidative stress, apoptosis and hippocampal damage in brain of a spontaneously stroke model.
Abstract Stroke is the most common cause of motor disabilities and is a major cause of mortality worldwide. Adult stem cells have been shown to be effective against neuronal degeneration through mechanisms that include both the recovery of neurotransmitter activity and a decrease in apoptosis and oxidative stress. We chose the lineage Stroke Prone Spontaneously Hypertensive Rat (SHRSP) as a model for stem cells therapy. SHRSP can develop such severe hypertension that they generally suffer a stroke at approximately one year of age. The aims of this study were to evaluate whether mesenchymal stem cells (MSC) decreas...
Source: Free Radical Biology and Medicine - February 10, 2014 Category: Biology Authors: Longoni Calió M, Sousa Marinho D, Mi Ko G, Rodrigues R, Ferraz Carbonel A, Missae Oyama L, Ormanji M, Pinoti Guirao T, Luiz Calió P, Aparecida Reis L, de Jesus Simões M, Lisboa do Nascimento T, Teixeira Ferreira A, Rejane Antônio Bertoncini C Tags: Free Radic Biol Med Source Type: research

Renin-angiotensin system activation and imbalance of matrix metalloproteinase-9/tissue inhibitor of matrix metalloproteinase-1 in cold-induced stroke
Publication date: Available online 12 June 2019Source: Life SciencesAuthor(s): Yu-ying Su, Huan-min Li, Zhen-xing Yan, Ming-chun Li, Ji-peng Wei, Wen-xia Zheng, Si-qin Liu, Yi-ting Deng, Hui-fang Xie, Chun-guang LiAbstractAimsIn the present study, we investigated the roles of renin-angiotensin system (RAS) activation and imbalance of matrix metalloproteinase-9 (MMP-9)/tissue inhibitor of matrix metalloproteinase-1 (TIMP-1) in cold-induced stroke during chronic hypertension, as well as the protective effects of captopril and recombinant human TIMP-1 (rhTIMP-1).Main methodsRats were randomly assigned to sham; 2-kidney, 2-cli...
Source: Life Sciences - June 12, 2019 Category: Biology Source Type: research

Sleep-time ambulatory blood pressure as a prognostic marker of vascular and other risks and therapeutic target for prevention by hypertension chronotherapy: Rationale and design of the Hygia Project.
This article describes the rationale, objectives, design and conduct of the ambulatory blood pressure monitoring (ABPM)-based Hygia Project. Given the substantial evidence of the significantly better prognostic value of ABPM compared to clinic BP measurements, several international guidelines now propose ABPM as a requirement to confirm the office diagnosis of hypertension. Nonetheless, all previous ABPM outcome investigations, except the Monitorización Ambulatoria para Predicción de Eventos Cardiovasculares study (MAPEC) study, relied upon only a single, low-reproducible 24 h ABPM assessment per participant done at stud...
Source: Chronobiology International - May 23, 2016 Category: Biology Authors: Hermida RC Tags: Chronobiol Int Source Type: research

Adjuvant-induced mono-arthritis potentiates cerebral hemorrhage in the spontaneously hypertensive rats
Publication date: Available online 21 February 2016 Source:Life Sciences Author(s): Amy Randell, Noriko Daneshtalab Aims Patients with rheumatoid arthritis (RA), have a higher incidence of hypertension and stroke than the normal population. Currently there exists no animal model to study the pathogenic interactions of hemorrhagic stroke (HS) subsequent to chronic inflammation and hypertension. We have created and defined a hypertensive-mono-arthritic animal model who demonstrate gross signs of cerebral hemorrhage in presence of mono-arthritis. Main methods Spontaneously hypertensive rats (SHR) were fed either a high s...
Source: Life Sciences - February 21, 2016 Category: Biology Source Type: research

Androgens ’ effects on cerebrovascular function in health and disease
AbstractAndrogens affect the cerebral vasculature and may contribute to sex differences in cerebrovascular diseases. Men are at a greater risk for stroke and vascular contributions to cognitive impairment and dementia (VCID) compared to women throughout much of the lifespan. The cerebral vasculature is a target for direct androgen actions, as it expresses several sex steroid receptors and metabolizing enzymes. Androgens ’ actions on the cerebral vasculature are complex, as they have been shown to have both protective and detrimental effects, depending on factors such as age, dose, and disease state. When administered chr...
Source: Biology of Sex Differences - June 29, 2020 Category: Biology Source Type: research

Association of Self‐Reported Familial History of Cardiometabolic Disease with Metabolic Syndrome in Apparently Healthy Urban Colombian Men
Discussionthe findings of association of this study together with the previous reports are evidence of the importance of hereditary component as independent predictor of cardiovascular risk factors and its clustering, as well as of possible specific association patterns between FH of CMD and MetS depending on evaluated population in terms of ethnic groups and geographic region. Further studies are required in other populations, as well as exploration of genetic markers of CMD regarding to MetS. Am. J. Hum. Biol., 2013. © 2013 Wiley Periodicals, Inc.
Source: American Journal of Human Biology - February 5, 2013 Category: Biology Authors: Milton F. Suárez‐Ortegón, Alejandra Arbeláez, Mildrey Mosquera, Fabian Méndez, Alberto Pradilla, Cecilia Aguilar‐de Plata Tags: Short Report Source Type: research

Arterial Stiffening Provides Sufficient Explanation for Primary Hypertension
by Klas H. Pettersen, Scott M. Bugenhagen, Javaid Nauman, Daniel A. Beard, Stig W. Omholt Hypertension is one of the most common age-related chronic disorders, and by predisposing individuals for heart failure, stroke, and kidney disease, it is a major source of morbidity and mortality. Its etiology remains enigmatic despite intense research efforts over many decades. By use of empirically well-constrained computer models describing the coupled function of the baroreceptor reflex and mechanics of the circulatory system, we demonstrate quantitatively that arterial stiffening seems sufficient to explain age-related emergenc...
Source: PLoS Computational Biology - May 22, 2014 Category: Biology Authors: Klas H. Pettersen et al. Source Type: research

Irregular 24-hour activity rhythms and the metabolic syndrome in older adults.
Abstract Circadian rhythms - near 24 h intrinsic biological rhythms - modulate many aspects of human physiology and hence disruption of circadian rhythms may have an important impact on human health. Experimental work supports a potential link between irregular circadian rhythms and several key risk factors for cardiovascular disease including hypertension, obesity, diabetes and dyslipidemia, collectively termed the metabolic syndrome. While several epidemiological studies have demonstrated an association between shift-work and the components of the metabolic syndrome in working-age adults, there is a relative p...
Source: Chronobiology International - June 10, 2015 Category: Biology Authors: Sohail S, Yu L, Bennett DA, Buchman AS, Lim AS Tags: Chronobiol Int Source Type: research

Factors Regulate the Renal Circulation in Spontaneously Hypertensive Rats
Publication date: Available online 26 June 2015 Source:Saudi Journal of Biological Sciences Author(s): Ahmad F. Ahmeda , Mohammed Alzoghaibi Hypertension is one of the leading causes of health morbidity and mortality which are linked to many life threatening diseases such as stroke heart problems and renal dysfunction. The integrity of renal microcirculation is crucial to maintain the clearance and the excretory function in the normotensive and hypertensive condition. Furthermore, any alteration in the renal function is involved in the pathophysiology of hypertension. The aim of this review is to provide a brief discussi...
Source: Saudi Journal of Biological Sciences - June 27, 2015 Category: Biology Source Type: research

Factors regulating the renal circulation in spontaneously hypertensive rats
Publication date: Available online 26 June 2015 Source:Saudi Journal of Biological Sciences Author(s): Ahmad F. Ahmeda, Mohammed Alzoghaibi Hypertension is one of the leading causes of health morbidity and mortality which are linked to many life threatening diseases such as stroke heart problems and renal dysfunction. The integrity of renal microcirculation is crucial to maintaining the clearance and the excretory function in the normotensive and hypertensive conditions. Furthermore, any alteration in the renal function is involved in the pathophysiology of hypertension. The aim of this review is to provide a brief dis...
Source: Saudi Journal of Biological Sciences - July 17, 2015 Category: Biology Source Type: research