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Condition: Hypertension
Nutrition: Weight Loss

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Total 251 results found since Jan 2013.

Overweight and obese middle-aged women have increased risk of venous thromboembolism, particularly following surgery
Commentary on Parkin L, Sweetland S, Balkwill A, et al.. for the Million Women Study Collaborators. Body mass index, surgery and risk of venous thromboembolism in middle-aged women: a cohort study. Circulation 2012;125:1897–904. Implications for practice and research Obesity is associated with an increased risk of venous thromboembolism (VTE) including both spontaneous and postoperative events. Further research is needed regarding factors responsible for the increase in postoperative VTE in overweight patients, and whether management should be altered (eg, increased focus on postoperative mobilisation, altered doses ...
Source: Evidence-Based Nursing - March 8, 2013 Category: Nursing Authors: McRae, S. Tags: Drugs: cardiovascular system, Stroke, Hypertension, Obesity (nutrition), Venous thromboembolism, Health education, Obesity (public health), Screening (public health), Smoking, Tobacco use Women ' s health Source Type: research

Pharmacotherapy of obesity: clinical treatments and considerations.
Abstract Obesity is a world-wide epidemic associated with significant morbidity and mortality which costs billions of dollars per year. The associated related conditions are many and include heart disease, stroke, type II diabetes mellitus, sleep apnea and certain types of cancer. Given that it is a multifactorial problem, the treatments must also address the numerous causes associated with the development of obesity. The neurohormonal regulation of feeding and energy is a complex system often necessitating modification through more than 1 pathway to achieve weight loss. Therefore, in addition to lifestyle changes...
Source: The American Journal of the Medical Sciences - April 1, 2013 Category: Journals (General) Authors: Holes-Lewis KA, Malcolm R, O'Neil PM Tags: Am J Med Sci Source Type: research

Just a few extra pounds increases heart failure risk
Conclusion This large study uses an interesting genetic approach (Mendelian randomisation) to suggest obesity increases the risk of heart failure and adverse changes in liver enzymes. The combination of a very large sample, prospectively collected information, and a wide range of cardiometabolic measures lend credibility to the findings. The method the researchers used is also thought to reduce the chances of factors other than BMI influencing results, and the chance that the ‘outcome’ could be causing the ‘exposure’ (reverse causality). The main limitation of this kind of research is that assumptions need to be m...
Source: NHS News Feed - June 26, 2013 Category: Consumer Health News Tags: Obesity Lifestyle/exercise Source Type: news

If you could propose one idea to help improve health care delivery in the United States, what would it be?
Thumbnail: Tags: conversationsphrma conversationslarry hausnermyrl weinbergchris hansennancy brownContributors: 11621161115911631173Contributions: Read Larry Hausner's bio Despite the rapid development of innovative technologies in the health care field, we have yet to discover a panacea that will easily transform our health care system into one that provides high-quality and cost-effective care.  What we have discovered and come to agree on over the last decade is that our sick care system must be reconfigured to a health care system that emphasizes wellness and prevention.  For that reason, I offer ...
Source: PHRMA - June 24, 2013 Category: Pharmaceuticals Authors: rlowe Source Type: news

The role of nutrition, nutraceuticals, vitamins, antioxidants, and minerals in the prevention and treatment of hypertension.
Abstract Macronutrient and micronutrient deficiencies are very common in the general population and may be even more common in patients with hypertension and cardiovascular disease due to genetic or environmental causes and prescription drug use. These deficiencies will have an enormous impact on present and future cardiovascular health and outcomes, such as hypertension, myocardial infarction, stroke and renal disease, and on overall health costs. The diagnosis and treatment of these nutrient deficiencies can reduce blood pressure; improve vascular health, endothelial dysfunction, and vascular biology; and decrea...
Source: Alternative Therapies in Health and Medicine - September 20, 2013 Category: Complementary Medicine Authors: Houston MC Tags: Altern Ther Health Med Source Type: research

Guideline: ACP recommends weight loss and CPAP therapy for obstructive sleep apnea
People diagnosed with obstructive sleep apnea (OSA) should not consider surgery, according to new recommendations from the American College of Physicians (ACP). Instead, ACP recommends that patients lose weight and use continuous positive airway pressure (CPAP) as initial therapy. More than 18 million American adults have sleep apnea, which increases the risk of high blood pressure, heart attack, stroke, heart failure, and diabetes and increases the chance of driving or other accidents. Sleep apnea is a leading cause of excessive daytime sleepiness...
Source: Health News from Medical News Today - September 25, 2013 Category: Consumer Health News Tags: Sleep / Sleep Disorders / Insomnia Source Type: news

Menopause and Weight Gain
Many women approaching the menopause will experience a number of symptoms, including vaginal dryness, hot flushes and a lack of sex drive. However another symptom that may arise as a result of the menopause is weight gain. Most commonly occurring around the hips and abdomen, this menopausal symptom for the majority of women is considered to be the least desirable. Photo: Nikodem Nijaki: Wikipedia Although the exact factors that contribute to weight gain are not entirely understood, it is known that a decline in oestrogen levels, a loss of muscle tissue and lifestyle factors are part of the cause. Though it can be argued t...
Source: The Hysterectomy Association - November 7, 2013 Category: OBGYN Authors: Linda Parkinson-Hardman Tags: menopause hormone replacement therapy oestrogen weight gain Source Type: news

The extra‐pancreatic effects of GLP‐1 receptor agonists: a focus on the cardiovascular, gastrointestinal and central nervous systems
Abstract The glucagon‐like peptide‐1 receptor agonists (GLP‐1RAs) exenatide and liraglutide have been shown to improve glycaemic control and beta‐cell function with a low risk of hypoglycaemia in people with type 2 diabetes. GLP‐1 receptors are also expressed in extra‐pancreatic tissues and trial data suggest GLP‐1RAs also have effects beyond their glycaemic actions. Preclinical studies using native GLP‐1 or GLP‐1RAs provide substantial evidence for cardioprotective effects, while clinical trial data have demonstrated beneficial actions on hypertension and dyslipidaemia in people with type 2 diabetes. Sig...
Source: Diabetes, Obesity and Metabolism - December 24, 2013 Category: Endocrinology Authors: J Seufert, B Gallwitz Tags: Unsolicited Review Article Source Type: research

Modest weight loss does not decrease cardiovascular morbidity and mortality in adults with type 2 diabetes
Commentary on: Wing RR, Bolin P, Brancati FL, et al.. Look AHEAD Research Group. Cardiovascular effects of intensive lifestyle intervention in type 2 diabetes. N Engl J Med 2013;369:145–54. Context Diet, physical activity and weight loss are recommended in the management of type 2 diabetes. This recommendation is largely based on short-term intervention studies which show improvements in cardiovascular risk factors including glycaemic control, lipids, blood pressure and inflammation. The Look AHEAD (Action for Health in Diabetes) randomised controlled trial (RCT) studied the impact of long-term weight loss through an...
Source: Evidence-Based Medicine - March 19, 2014 Category: Internal Medicine Authors: Davis, N. J., Goswami, G. Tags: Clinical trials (epidemiology), Epidemiologic studies, Immunology (including allergy), Drugs: cardiovascular system, Stroke, Hypertension, Diet, Ischaemic heart disease, Diabetes Therapeutics Source Type: research

Cardiovascular effects of current and future anti-obesity drugs.
Abstract The prevalence of obesity increases and is associated with increases in co-morbidities e.g. type 2 diabetes, hyperlipidemia, hypertension, obstructive sleep apnea, heart disease, stroke, asthma, several forms of cancer, depression, and may result in reduction of expected remaining lifespan. We have reviewed the adverse effects on the cardiovascular system of anti-obesity drugs now retracted from the market as well as the cardiovascular profile of current drugs and potential pathways which are considered for treatment of obesity. Fenfluramine, and sibutramine were withdrawn due to increased cardiovascular ...
Source: Current Vascular Pharmacology - May 24, 2014 Category: Drugs & Pharmacology Authors: Comerma-Steffensen S, Grann M, Andersen CU, Rungby J, Simonsen U Tags: Curr Vasc Pharmacol Source Type: research

NICE: 'Obese should be prescribed slimming clubs'
“GPs told to prescribe £100 slimming courses for millions of obese patients,” the Daily Mail reports. The news is based on new guidelines from the National Institute for Health and Care Excellence (NICE) that aim to encourage sustainable weight loss in the obese; “lose a little, and keep it off”. The guidance is mainly aimed at commissioners (who plan and agree which services will be provided in the NHS and monitor them), health professionals and groups who provide lifestyle weight management programmes. The recommendations may also be of interest to members of the public, including people who are overweight or o...
Source: NHS News Feed - May 28, 2014 Category: Consumer Health News Tags: Lifestyle/exercise Food/diet Obesity QA articles Source Type: news

The effect of a single nucleotide polymorphism of the CYP4F2 gene on blood pressure and 20-hydroxyeicosatetraenoic acid excretion after weight loss
Background:Genetic background partly determines the efficacy of interventions to lower blood pressure (BP). The CYP4F2 and CYP4A11 enzymes are renal 20-hydroxyeicosatetraenoic acid (20-HETE) synthases that regulate BP. Gene variants of CYP4F2 and CYP4A11 associate with hypertension and stroke. We showed that a gene variant of CYP4F2 but not CYP4A11 was associated with increased 20-HETE excretion and BP. Aim:To compare BP and 20-HETE responses in carriers of the CYP4F2 1347G/A polymorphism and controls CYP4F2-GG (wildtype), during weight loss. Methods:Volunteers genotyped as CYP4F2GA/AA (n = 26) and controls genotyped a...
Source: Journal of Hypertension - June 6, 2014 Category: Cardiology Tags: ORIGINAL PAPERS: Obesity Source Type: research

Weight loss herbal intervention therapy (W-LHIT) a non-appetite suppressing natural product controls weight and lowers cholesterol and glucose levels in a murine model
Conclusions: W-LHIT significantly and safely reduced body weight, normalized glucose and cholesterol levels in obese mice, without suppression of appetite, and increased adipocyte PPARgamma and FABP4 gene expression.
Source: BMC Complementary and Alternative Medicine - July 23, 2014 Category: Complementary Medicine Authors: Nan YangDanna ChungChangda LiuBanghao LiangXiu-Min Li Source Type: research

How to tame stubbornly high blood pressure
High blood pressure is a leading cause of stroke and heart disease. Dozens of medications and other therapies are available to treat high blood pressure, also known as hypertension. Yet many people can't get their blood pressure under control even by taking multiple medications, reports the September 2014 Harvard Heart Letter. "When people have high blood pressure despite being on three different medications, including a thiazide diuretic, they have what's known as resistant hypertension," says Dr. Joshua Beckman, a cardiologist at Harvard-affiliated Brigham and Women's Hospital. Some people with resistant hypertension may...
Source: New Harvard Health Information - August 23, 2014 Category: Consumer Health News Source Type: news

The STRIDE Weight Loss and Lifestyle Intervention for Individuals Taking Antipsychotic Medications: A Randomized Trial.
Conclusions: Individuals taking antipsychotic medications can lose weight and improve fasting glucose levels. Increasing reach of the intervention is an important future step. PMID: 25219423 [PubMed - as supplied by publisher]
Source: The American Journal of Psychiatry - September 15, 2014 Category: Psychiatry Authors: Green CA, Yarborough BJ, Leo MC, Yarborough MT, Stumbo SP, Janoff SL, Perrin NA, Nichols GA, Stevens VJ Tags: Am J Psychiatry Source Type: research