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Differences in wake‐up and unknown onset stroke examined in a stroke registry
ConclusionWUS has lower rates of ICH but similar stroke severity and outcomes to AOS. UOS prevalence appears to be increasing, with higher stroke severity and worse prognosis.
Source: International Journal of Stroke - October 1, 2014 Category: Neurology Authors: John M. Reid, Dingwei Dai, Bharath Cheripelli, Christine Christian, Yvette Reidy, Gord J. Gubitz, Stephen J. Phillips Tags: Research Source Type: research

Codeine is associated with poor prognosis in acute stroke
ConclusionUse of codeine‐containing analgesics is associated with a poorer short‐term prognosis and an increased occurrence of complications in the acute phase after a stroke. The highly significant findings suggest that codeine has a negative effect on acute stroke patients. The study reflects exploratory analyses and prospective studies are necessary to determine the background of the association observed in our study. Use of codeine‐containing analgesics is associated with a poorer short‐term prognosis and an increased occurrence of complications in the acute phase after a stroke. The highly significant finding...
Source: Brain and Behavior - November 19, 2017 Category: Neurology Authors: Stian T. Ryste, Bernt A. Engelsen, Halvor Naess Tags: ORIGINAL RESEARCH Source Type: research

Thrombolysis in patients with prior stroke within the last 3 months
ConclusionsIn patients with prior stroke within the last 3 months, none of the sICHs and only one asymptomatic intracerebral hemorrhage occurred in the region of the former infarct. The high mortality was influenced by four patients, who died until discharge due to acute major index stroke. It is reasonable to include these patients in randomized clinical trials and registries to assess further their thrombolysis benefit−risk ratio.
Source: European Journal of Neurology - July 17, 2014 Category: Neurology Authors: M. R. Heldner, H. P. Mattle, S. Jung, U. Fischer, J. Gralla, C. Zubler, M. El‐Koussy, G. Schroth, M. Arnold, M.‐L. Mono Tags: Original Article Source Type: research

Early apixaban therapy after ischemic stroke in patients with atrial fibrillation
ConclusionsSymptomatic HT rates are likely to be low in randomized trials of DOAC initiation post-stroke. Recurrent ischemic stroke may be the major clinical outcome. These data may be used as expected event rates when calculating sample size requirements for future safety/efficacy trials of early versus late DOAC initiation after AF-related stroke.
Source: Journal of Neurology - January 3, 2021 Category: Neurology Source Type: research

Mild stroke: safety and outcome in patients receiving thrombolysis.
CONCLUSIONS: This study highlights the efficacy of rt-PA in patients with acute cerebral ischemia presenting with mild symptoms and confirms the low-risk profile of this treatment. PMID: 24588505 [PubMed - in process]
Source: Acta Neurologica Scandinavica. Supplementum - March 9, 2014 Category: Neurology Authors: Logallo N, Kvistad CE, Naess H, Waje-Andreassen U, Thomassen L Tags: Acta Neurol Scand Suppl Source Type: research

Thrombectomy assisted by carotid stenting in acute ischemic stroke management: benefits and harms
This study assesses the benefits and harms of thrombectomy assisted by carotid stenting and identifies factors associated with clinical outcome and procedural complications. Retrospective single-center analysis of 47 consecutive stroke patients with carotid occlusion or high-grade stenosis and concomitant intracranial embolus treated between September 2011 and December 2014. Benefits included early improvement of stroke severity (NIHSS ≥ 10) or complete remission within 72 h and favorable long-term outcome (mRS ≤ 2). Harms included complications during and following EVT. Mean age was 64.3 years (standard deviatio...
Source: Journal of Neurology - September 7, 2015 Category: Neurology Source Type: research

Prognosis associated with asymptomatic intracranial hemorrhage after acute ischemic stroke: a systematic review and meta-analysis
ConclusionsOur results indicate that compared with patients without ICH, those who developed aICH during the acute stage of ischemic stroke had an increasing risk of worse outcome, especially in patients with endovascular therapy.
Source: Journal of Neurology - March 8, 2022 Category: Neurology Source Type: research

Mild stroke: safety and outcome in patients receiving thrombolysis
ConclusionsThis study highlights the efficacy of rt‐PA in patients with acute cerebral ischemia presenting with mild symptoms and confirms the low‐risk profile of this treatment.
Source: Acta Neurologica Scandinavica - March 4, 2014 Category: Neurology Authors: N. Logallo, C. E. Kvistad, H. Naess, U. Waje‐Andreassen, L. Thomassen Tags: Original Article Source Type: research

A Clinical-Radiomics Nomogram for Functional Outcome Predictions in Ischemic Stroke
ConclusionThis novel noninvasive clinical-radiomics nomogram shows good performance in predicting ischemic stroke prognosis.
Source: Neurology and Therapy - June 25, 2021 Category: Neurology Source Type: research

Intravenous thrombolysis for patients with in ‐hospital stroke onset: propensity‐matched analysis from the SITS‐EAST registry
ConclusionsOur findings underline the safety and efficacy of IVT for IHS. They also underscore the potential of reducing in‐hospital delays for timely tPA delivery in patients with IHS.This article is protected by copyright. All rights reserved.
Source: European Journal of Neurology - September 9, 2017 Category: Neurology Authors: Georgios Tsivgoulis, Aristeidis H. Katsanos, Pavla Kadlecov á, Anna Czlonkowska, Adam Kobayashi, Miroslav Brozman, Viktor Švigelj, Laszlo Csiba, Klara Fekete, Janika Kõrv, Vida Demarin, Aleksandras Vilionskis, Dalius Jatuzis, Yakup Krespi, Theodore Kar Tags: Original Article Source Type: research

Mechanical Thrombectomy in Acute Ischemic Stroke Using a  Manually Expandable Stent Retriever (Tigertriever)
ConclusionThe Tigertriever offers a  safe and effective treatment option in ischemic stroke due to LVOs with reperfusion rates and a safety profile similar to alternative devices. The Tigertriever is a promising bail-out tool in complex cases. Its role as a first line device has to be evaluated in further prospective studies.
Source: Clinical Neuroradiology - June 10, 2020 Category: Neurology Source Type: research

Combined therapy of intensive statin plus intravenous rt-PA in acute ischemic stroke: the INSPIRE randomized clinical trial
ConclusionThe INSPIRE study indicated that intensive statin therapy may not improve clinical outcomes compared with the low dose of statin therapy in AIS patients undergoing intravenous thrombolysis, and the two groups had similar safety profile.Clinical trial registrationURL:http://www.chictr.org. Unique identifier: ChiCTR-IPR-16008642
Source: Journal of Neurology - February 8, 2021 Category: Neurology Source Type: research

Functional and technical outcomes in acute ischemic stroke patients with hyperdense middle cerebral artery sign treated with endovascular thrombectomy
ConclusionPatients with HMCAS treated with EVT do not have a worse outcome at 3  months compared with no-HMCAS patients. Patients with HMCAS required a greater number of thrombus passes and longer procedure times.
Source: Frontiers in Neurology - May 25, 2023 Category: Neurology Source Type: research

Stereotactic Catheter Ventriculocisternostomy for Clearance of Subarachnoid Hemorrhage Clinical Sciences
Conclusions—STX-VCS was feasible and safe in patients with severe aneurysmal subarachnoid hemorrhage. Initial results indicate that DCI and mortality can be reduced, and neurological outcome may be improved with this method.
Source: Stroke - September 25, 2017 Category: Neurology Authors: Roland Roelz, Volker A. Coenen, Christian Scheiwe, Wolf-Dirk Niesen, Karl Egger, Istvan Csok, Rainer Kraeutle, Ramazan Jabbarli, Horst Urbach, Peter C. Reinacher Tags: Cerebral Aneurysm, Cerebrovascular Disease/Stroke Original Contributions Source Type: research

Maximizing First-Pass Complete Reperfusion with SAVE
ConclusionSAVE is fast and appears to be very effective in terms of first-pass complete reperfusion in patients with LVO.
Source: Clinical Neuroradiology - February 12, 2017 Category: Neurology Source Type: research

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