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International Stroke Conference: Mixed Results in Trial of Minimally Invasive Surgery for Intracerebral Hemorrhage
No abstract available
Source: Neurology Today - March 7, 2019 Category: Neurology Tags: At the Meetings Source Type: research

Psychosis Polyrisk Score (PPS) for the Detection of Individuals At-Risk and the Prediction of Their Outcomes
Conclusions The combination of risk/protective factors encompassing genetic (PRS) and non-genetic information (PPS) holds promise for overcoming the epidemiological weakness of the CHR-P paradigm. The PPS conceptually and empirically developed here will facilitate future research in this field and hopefully advance our ability to detect individuals at-risk for psychosis and forecast their clinical outcomes. Ethics Statement This study was supported by the King's College London Confidence in Concept award from the Medical Research Council (MRC) (MC_PC_16048) to PF-P. This study also represents independent researc...
Source: Frontiers in Psychiatry - April 16, 2019 Category: Psychiatry Source Type: research

Challenge to the Intestinal Mucosa During Sepsis
Conclusion The impact of sepsis on the gut is manifold, e.g., sepsis mediated alteration of the gut-blood barrier and increase in the intestinal permeability, which may correlate with the phenomena of bacterial translocation and lymphatic activation (“toxic-lymph”). Systemic consequences of sepsis are widespread and concern to the coagulative system, the microbiome as well as enzymes, such as pancreatic proteases, MMPs and IAPs. Nevertheless, the therapeutic approaches for modulating the mucosal immune system are still rarely effective in daily routine. Recent published studies showing that treatment with ...
Source: Frontiers in Immunology - April 29, 2019 Category: Allergy & Immunology Source Type: research

Beta-Blockade in Aneurysmal Subarachnoid Hemorrhage: a Systematic Review and Meta-Analysis
ConclusionsIn adult patients with aSAH, beta-blocker therapy is associated with a mortality benefit. Studies are generally of a low quality with considerable clinical heterogeneity. Prospective large interventional trials with patient centered outcomes are required to validate this finding.
Source: Neurocritical Care - January 27, 2020 Category: Neurology Source Type: research

Comparison of hemostatic agents in patients with spontaneous intracerebral hemorrhage: A protocol for a network meta-analysis
Conclusion: This study will provide high quality evidence about effects of different hemostatic agents in patients with sICH. Registration number: CRD42020196039.
Source: Medicine - October 23, 2020 Category: Internal Medicine Tags: Research Article: Study Protocol Systematic Review Source Type: research

E-085 Interventional and diagnostic neuroradiology fellowship education in the COVID-19 era
ConclusionElective neurointerventional case numbers decreased as a result of the COVID-19 pandemic, particularly impacting the fourth quarter of the 2019-2020 academic year (April - June). Similarly, there was a sizable decrease in diagnostic neuroradiology case volume during this same time period. The decrease in procedural and diagnostic neuroradiology cases raised concerns regarding the educational experience for both diagnostic and neurointerventional radiology fellows. However, as a result of decreased case volume, fellowship education was rapidly augmented with a wide variety of online webinars, lectures, case confer...
Source: Journal of NeuroInterventional Surgery - July 26, 2021 Category: Neurosurgery Authors: Wilseck, Z., Bamezai, S., Novakovic, N., Copelan, A., Wilseck, J., Srinivasan, A., Pandey, A., Thompson, G., Gemmete, J., Chaudhary, N. Tags: Electronic poster abstracts Source Type: research

Multicentre observational study on practice of ventilation in brain injured patients: the VENTIBRAIN study protocol
Introduction Mechanical ventilatory is a crucial element of acute brain injured patients’ management. The ventilatory goals to ensure lung protection during acute respiratory failure may not be adequate in case of concomitant brain injury. Therefore, there are limited data from which physicians can draw conclusions regarding optimal ventilator management in this setting. Methods and analysis This is an international multicentre prospective observational cohort study. The aim of the ‘multicentre observational study on practice of ventilation in brain injured patients’—the VENTIBRAIN study—is t...
Source: BMJ Open - August 11, 2021 Category: General Medicine Authors: Robba, C., Citerio, G., Taccone, F. S., Galimberti, S., Rebora, P., Vargiolu, A., Pelosi, P., VENTIBRAIN Enlarged Steering committee members, VENTIBRAIN, Mandelli, Mancebo, Stevens, Meyfroidt, Badenes, Torre, Helbok, Suarez, Stocchetti, Abreu, Schultz, Ci Tags: Open access, Intensive care Source Type: research

Genome-Wide Association Study of Clinical Outcome After Aneurysmal Subarachnoid Haemorrhage: Protocol
AbstractAneurysmal subarachnoid haemorrhage (aSAH) results in persistent clinical deficits which prevent survivors from returning to normal daily functioning. Only a small fraction of the variation in clinical outcome following aSAH is explained by known clinical, demographic and imaging variables; meaning additional unknown factors must play a key role in clinical outcome. There is a growing body of evidence that genetic variation is important in determining outcome following aSAH. Understanding genetic determinants of outcome will help to improve prognostic modelling, stratify patients in clinical trials and target novel...
Source: Translational Stroke Research - January 6, 2022 Category: Neurology Source Type: research

A Meta-Analysis of Using Protamine for Reducing the Risk of Hemorrhage During Carotid Recanalization: Direct Comparisons of Post-operative Complications
Conclusion: Among included participants undergoing recanalization, the use of protamine is effective in reducing hematoma without increasing the risk of having other complications. Besides, more evidence-based performance is needed to supplement this opinion due to inherent limitations.
Source: Frontiers in Pharmacology - February 25, 2022 Category: Drugs & Pharmacology Source Type: research

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