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Condition: Ischemic Stroke
Therapy: Thrombolytic Therapy

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Total 959 results found since Jan 2013.

A deuterohemin peptide protects cerebral ischemia-reperfusion injury by preventing oxidative stress in vitro and in vivo
In conclusion, DhHP-3 has bioactivity of CIRI inhibition through suppression of the ROS-induced apoptosis.PMID:36442518 | DOI:10.1016/j.yexcr.2022.113432
Source: Experimental Cell Research - November 28, 2022 Category: Cytology Authors: Fanwei Meng Junfeng Ke Jinze Li Changhui Zhao Jiaqing Yan Liping Wang Source Type: research

Evaluation of the quantitative performance of non-enhanced dual-energy CT X-map in detecting acute ischemic brain stroke: A model observer study using computer simulation
Acute ischemic stroke (AIS) is a critical brain disease that is prevalent in developed countries [1]. Rapid and accurate diagnosis of AIS is highly desirable before implementing thrombolytic therapy or mechanical thrombectomy, which helps improve the prognosis of patients with ischemic stroke [2 –4].
Source: Physica Medica: European Journal of Medical Physics - November 10, 2022 Category: General Medicine Authors: Toshihide Itoh, Kyo Noguchi Tags: Original paper Source Type: research

The SON2A2 score: A novel grading scale for predicting hemorrhage and outcomes after thrombolysis
ConclusionThe SON2A2 score is a simple, efficient, quick, and easy-to-perform scale for predicting the risk of sICH and outcome after intravenous r-tPA thrombolysis within 4.5 h in patients with ischemic stroke, and risk assessment using this test has the potential for early and personalized management of this disease in high-risk patients.
Source: Frontiers in Neurology - October 31, 2022 Category: Neurology Source Type: research

A Novel Nomogram for Predicting Poor 6-Month Function in Patients With Acute Ischemic Stroke Receiving Thrombolysis
Background Patients with acute ischemic stroke (AIS) receiving thrombolysis with good function at discharge are usually ignored. Their functional deterioration after discharge not only compromises the effectiveness of thrombolytic therapy but also reduces their long-term quality of life, which is not conducive to the advancement of medical healthcare and continuing care. Objective The aims of this study were to explore the risk factors for poor 6-month function in patients with AIS receiving thrombolysis with good function at discharge and construct a novel nomogram model. Methods This case-control study ...
Source: Journal of Cardiovascular Nursing - October 17, 2022 Category: Nursing Tags: ARTICLES AVAILABLE ONLINE ONLY Source Type: research

The impact of leptomeningeal collaterals in acute ischemic stroke: a systematic review and meta-analysis
ConclusionsThe relative risk of favorable clinical outcome is more in patients with good pretreatment CBF. This could be explained due to better chances of recanalization combined with a lesser risk of intracerebral hemorrhage with good CBF status.
Source: Neurological Sciences - October 4, 2022 Category: Neurology Source Type: research

Neurophysiology tools to lower the stroke onset to treatment time during the golden hour: microwaves, bioelectrical impedance and near infrared spectroscopy
Ann Med. 2022 Dec;54(1):2658-2671. doi: 10.1080/07853890.2022.2124448.ABSTRACTReperfusion therapy administration timing in acute ischaemic stroke is the main determinant of patients' mortality and long-term disability. Indeed, the first hour from the stroke onset is defined the "golden hour", in which the treatment has the highest efficacy and lowest side effects. Delayed ambulance transport, inappropriate triage and difficulty in accessing CT scans lead to delayed onset to treatment time (OTT) in clinical practice. To date brain CT scan is needed to rule out intracranial haemorrhage, which is a major contraindication to t...
Source: Annals of Medicine - September 26, 2022 Category: Internal Medicine Authors: Lazzaro di Biase Adriano Bonura Maria Letizia Caminiti Pasquale Maria Pecoraro Vincenzo Di Lazzaro Source Type: research

Effect of drug use in the treatment of acute ischemic stroke: A scoping review
CONCLUSION: Evidence for thrombolytic and thrombectomy treatment in drug users remains limited. Controlled studies are needed to examine complication profile and outcomes following thrombolytic and thrombectomy treatment in this population.PMID:36128166 | PMC:PMC9479649 | DOI:10.25259/SNI_561_2022
Source: Surgical Neurology International - September 21, 2022 Category: Neurosurgery Authors: Nisha Dabhi Panagiotis Mastorakos Jennifer D Sokolowski Ryan T Kellogg Min S Park Source Type: research