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Condition: Ischemic Stroke
Procedure: Perfusion
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Total 2383 results found since Jan 2013.
Tmax volume can predict clinical type in patients with acute ischemic stroke
CONCLUSION: The Tmax volume derived from perfusion imaging predicts the clinical classification of AIS patients before EVT.PMID:37469274 | DOI:10.1002/brb3.3163
Source: Atherosclerosis - July 20, 2023 Category: Cardiology Authors: Fumihisa Kishi Ichiro Nakagawa Seigo Kimura Daiji Ogawa Ryokichi Yagi Keiichi Yamada Hirokatsu Taniguchi Source Type: research
White Matter Cerebrovascular Reactivity: Effects of Microangiopathy and Proximal Occlusions on the Dynamic BOLD Response
CONCLUSION: Our results suggest additive effects of microvascular and macrovascular disease upon white matter CVR, but with greater overall effects relating to macrovascular SOD than to apparent microangiopathy. Dynamic ACZ-BOLD presents a promising path towards a quantitative stroke risk imaging biomarker.BACKGROUND: Cerebral white matter (WM) microangiopathy manifests as sporadic or sometimes confluent high intensity lesions in MR imaging with T2-weighting, and bears known associations with stroke, cognitive disability, depression and other neurological disorders 1-5 . Deep white matter is particularly susceptible to isc...
Source: Atherosclerosis - July 3, 2023 Category: Cardiology Authors: J Michael Gee Xiuyuan Wang Siddhant Dogra Jelle Veraart Koto Ishida Seena Dehkharghani Source Type: research
The potential therapeutic effect of phosphodiesterase 5 inhibitors in the acute ischemic stroke (AIS)
In conclusion, PDE5 inhibitors may have potential roles in the management of AIS through modulation of CBF, cAMP/cGMP/NO pathway, neuroinflammation, and inflammatory signaling pathways. Preclinical and clinical studies are recommended in this regard.PMID:37395897 | DOI:10.1007/s11010-023-04793-1
Source: Molecular and Cellular Biochemistry - July 3, 2023 Category: Biochemistry Authors: Raed AlRuwaili Hayder M Al-Kuraishy Mubarak Alruwaili Amira Karam Khalifa Athanasios Alexiou Marios Papadakis Hebatallah M Saad Gaber El-Saber Batiha Source Type: research
Update on Large-Vessel Revascularization in Acute Ischemic Stroke
AbstractPurpose of reviewThis review presents the critical appraisal of current therapeutic strategies for patients with large-vessel occlusion (LVO) acute ischemic stroke (AIS). We provide the reader with most recent evidence supporting endovascular thrombectomy (EVT), different techniques used for thrombectomy, and highlight knowledge gaps regarding therapeutic efficacy of this intervention in respective subgroup of these patients based on site of occlusion, size of ischemic core, time from symptom onset, utility of concurrent intravenous thrombolysis (IVT), mild strokes, or tandem occlusions.Recent findingsEVT is the es...
Source: Current Treatment Options in Neurology - July 1, 2023 Category: Neurology Source Type: research
Clinical Significance and Influencing Factors of Microvascular Tissue Reperfusion After Macrovascular Recanalization
In this study, we aimed to investigate the impact of tissue optimal reperfusion (TOR) and its influencing factors. From December 1, 2020 to December 1, 2021, AIS patients with successful recanalization (modified Thrombolysis in Cerebral Infarction score [mTICI] ≥ 2b) after mechanical thrombectomy (MT) were retrospectively reviewed. Computed tomography perfusion was performed before and after MT. Successful reperfusion was assessed by TOR, defined as > 90% reduction of the Tmax > 6 s lesion volumes between baseline and early follow-up perfusion profiles. The impact of TOR on functional outcomes after...
Source: Translational Stroke Research - June 29, 2023 Category: Neurology Source Type: research
Assessment of Irreversible Tissue Injury in Extensive Ischemic Stroke —Potential of Quantitative Cerebral Perfusion
AbstractComputed tomography perfusion (CTP) is used as a tool to select ischemic stroke patients for endovascular treatment (EVT) and is currently investigated in the setting of extensive stroke with low Alberta Stroke Program Early CT scores (ASPECTS). The purpose of this study was to perform a comprehensive quantitative analysis of cerebral blood flow within the ischemic lesion compared to threshold-derived core lesion volumes. We hypothesized that the degree of cerebral blood volume (CBV) reduction within the ischemic lesion is predictive of irreversible tissue injury and functional outcome in patients with low ASPECTS....
Source: Translational Stroke Research - June 29, 2023 Category: Neurology Source Type: research
Association of admission plasma glucose level and cerebral computed tomographic perfusion deficit volumes
Hyperglycemia in acute ischemic stroke (AIS) is frequent and associated with worse outcome. Yet, strict glycemic control in AIS patients has failed to yield beneficial outcome. So far, the underlying pathophysiological mechanisms of admission hyperglycemia in AIS have remained not fully understood. We aimed to evaluate the yet equivocal association of hyperglycemia with computed tomographic perfusion (CTP) deficit volumes.
Source: Journal of the Neurological Sciences - June 26, 2023 Category: Neurology Authors: Laura Mannism äki, Nicolas Martinez-Majander, Gerli Sibolt, Olli Suomalainen, Katariina Bäcklund, Ahmed Elseoud Abou, Juha Järveläinen, Nina Forss, Sami Curtze Source Type: research
Pivotal role of multiphase computed tomography angiography for collateral assessment in patients with acute ischemic stroke
AbstractThe cerebral collateral circulation is the main compensatory mechanism that maintains the ischemic penumbra viable, the tissue at risk for infarction that can be saved if blood flow is restored by reperfusion therapies. In clinical practice, the extent of collateral vessels recruited after vessel occlusion can be easily assessed with computed tomography angiography (CTA) using two different techniques: single-phase CTA (sCTA) and multi-phase CTA (mCTA). Both these methodologies have demonstrated a high prognostic predictive value for prognosis due to the strong association between the presence of good collaterals a...
Source: La Radiologia Medica - June 23, 2023 Category: Radiology Source Type: research
Reduction of scan duration and radiation dose in cerebral CT perfusion imaging of acute stroke using a recurrent neural network
This study suggests that a recurrent VAE-GAN could potentially be used to predict a portion of CTP frames from truncated acquisitions, preserving the majority of clinical content in the images, and potentially reducing the scan duration and radiation dose simultaneously by 65% and 54.5%, respectively. 
.PMID:37327792 | DOI:10.1088/1361-6560/acdf3a
Source: Physics in Medicine and Biology - June 16, 2023 Category: Physics Authors: Mahdieh Dashtbani Moghari Amirhossein Sanaat Noel Young Krystal Moore Habib Zaidi Andrew Evans Roger R Fulton Andre Z Kyme Source Type: research
