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Specialty: Chemistry
Condition: Ischemic Stroke

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Total 308 results found since Jan 2013.

Risk of Ischemic Stroke in Primary Aldosteronism Patients.
CONCLUSIONS: Proteinuria, a medical history of coronary artery disease or left ventricular hypertrophy were associated with an increased risk of ischemic stroke in PA patients. Our results suggest that a public health initiative is necessary to enhance the follow up of proteinuria and to manage subsequent stroke among patients with aldosteronism. PMID: 25124866 [PubMed - as supplied by publisher]
Source: International Journal of Clinical Chemistry - August 11, 2014 Category: Chemistry Authors: Kao CC, Lin YH, Chang CC, Wu MS, Wu VC, TAIPAI Study Group Tags: Clin Chim Acta Source Type: research

Oxidative stress and post-stroke depression: possible therapeutic role of polyphenols?
Abstract Post-stroke depression is a common neuropsychiatric affective disorder that may develop after a stroke event. In addition to abnormalities in the biogenic amine neurotransmitters and cytokine expression induced by stroke we will focus on the role of oxidative stress and hypothesize that polyphenols may be useful as therapeutics targets for the treatment of post-stroke depression. In this paper, we discuss the hypothesis that increased oxidative stress in cerebral tissues during ischemia is implicated in the pathogenesis of depressive-like symptoms following stroke. There is substantive evidence regarding ...
Source: Current Medicinal Chemistry - November 12, 2014 Category: Chemistry Authors: Nabavi SF, Dean OM, Turner A, Sureda A, Daglia M, Nabavi SM Tags: Curr Med Chem Source Type: research

Serum lipoprotein(a) complexes with beta2-glycoprotein I levels in patients with ischemic stroke.
CONCLUSIONS: Serum β2-GPI-Lp(a) levels were increased in ischemic stroke patients. Elevated β2-GPI-Lp(a) levels were associated with the severity and clinical outcome of ischemic stroke. PMID: 24315780 [PubMed - as supplied by publisher]
Source: International Journal of Clinical Chemistry - December 4, 2013 Category: Chemistry Authors: Ma L, Wu J, Niu D, Yu R, Song J, Zhang C, Wang J Tags: Clin Chim Acta Source Type: research

Statins in stroke.
Conclusion: Treatment with statins prevents ischemic stroke, especially in patients with high cardiovascular risk and established atherosclerotic disease. It seems that both lipid lowering and pleiotropic effects contribute to these effects. PMID: 31218948 [PubMed - as supplied by publisher]
Source: Current Medicinal Chemistry - June 18, 2019 Category: Chemistry Authors: Aznaouridis K, Masoura C, Vlachopoulos C, Tousoulis D Tags: Curr Med Chem Source Type: research

Mesenchymal stem cells for ischemic stroke: progresses and possibilities.
Abstract Stroke is the most common reason of death and quality of life impairments due to neurological deficits in industrialized countries, currently afflicting 15 million people every year, and the numbers are expected to increase, mostly due to population aging. Although some acute phase therapies such as intravenous recombinant tissue plasminogen activator (rt-PA) and more recently endovascular treatment have been identified to improve stroke outcome, these therapies are available only for a small proportion of patients. The social and economic impact of stroke is immense because one of five stroke patient's d...
Source: Current Medicinal Chemistry - February 21, 2016 Category: Chemistry Authors: Ferri AL, Bersano A, Lisini D, Boncoraglio G, Frigerio S, Parati E Tags: Curr Med Chem Source Type: research

Elevated circulating homocysteine and high-sensitivity C-reactive protein jointly predicts post-stroke depression among Chinese patients with acute ischemic stroke.
CONCLUSIONS: Coexistence of both higher HCY and higher hs-CRP in the acute phase of ischemic stroke were associated with subsequent PSD, independently of established conventional risk factors. PMID: 29325799 [PubMed - as supplied by publisher]
Source: International Journal of Clinical Chemistry - January 8, 2018 Category: Chemistry Authors: Yin J, Zhong C, Zhu Z, Bu X, Xu T, Guo L, Wang X, Zhang J, Cui Y, Li D, Zhang J, Ju Z, Chen CS, Chen J, Zhang Y, He J Tags: Clin Chim Acta Source Type: research

Increased Growth Differentiation Factor 15 Is Associated with Unfavorable Clinical Outcomes of Acute Ischemic Stroke Proteomics and Protein Markers
CONCLUSIONS: High GDF-15 concentrations are independently associated with adverse clinical outcomes of acute ischemic stroke, suggesting that baseline serum GDF-15 could provide additional information to identify ischemic stroke patients at high risk of poor prognosis.
Source: Clinical Chemistry - March 27, 2019 Category: Chemistry Authors: Yin, J., Zhu, Z., Guo, D., Wang, A., Zeng, N., Zheng, X., Peng, Y., Zhong, C., Wang, G., Zhou, Y., Chen, C.-S., Chen, J., Zhang, Y., He, J. Tags: Proteomics and Protein Markers Source Type: research

Neuro-Clinical signatures of language impairments after acute stroke: a VBQ analysis of quantitative native CT scans.
CONCLUSION: In summary, the method applied to nCT scans performed in the acute stage of stroke provided robust and accurate information about brain lesions' location and size, as well as quantitative values. We found that nCT and VBQ analyses areeffective for identifying neural signatures of concomitant language impairments at the individual level, and neuroanatomical maps of aphasia at the population level. The signatures explicate the neurophysiological mechanisms underlying aetiology of the stroke. Ultimately, similar analyses with larger cohorts could lead to a more integrated multimodal model of behavior and brain ana...
Source: Current Topics in Medicinal Chemistry - February 9, 2020 Category: Chemistry Authors: Muller S, Dauyey K, Ruef A, Lorio S, Eskandari A, Schneider L, Beaud V, Roggenhofer E, Draganski B, Michel P, Kherif F Tags: Curr Top Med Chem Source Type: research

Ultrasound controlled anti-inflammatory polarization of platelet decorated microglia for targeted ischemic stroke therapy.
Abstract Stroke is a neurological disease with poor prognosis. Strong inflammatory and immune response exist after stroke, resulting in severe sequelae with high mortality. Microglia, the main immune cell in cerebrum, possess therapeutic potential for stroke as its specific anti-inflammatory phenotype can reduce inflammation and promote neuron regeneration. However, the on-demand anti-inflammatory polarization of microglia at stroke site is uncontrollable for therapeutic application. Here, we develop a platelet hybrid microglia platform which can specifically polarize to anti-inflammatory phenotype by ultrasound i...
Source: Angewandte Chemie - December 1, 2020 Category: Chemistry Authors: Li J, Li Y, Teng X, Yang C, Wang Y, Wang L, Dai Y, Sun H Tags: Angew Chem Int Ed Engl Source Type: research

Leukocyte-Mediated Tissue Injury in Ischemic Stroke.
Abstract Ischemic stroke remains a leading cause of death worldwide. While the underlying causes of stroke remain poorly defined, brain inflammation appears to be a characteristic response to the vascular insult and there is growing evidence suggesting a cause-effect relationship between the inflammatory response and stroke-induced brain dysfunction and tissue injury. In this review, we summarize evidence that implicates leukocytes in the pathophysiology of stroke and address some of the mediators that contribute to the recruitment and activation of leukocytes in the post-ischemic brain. The products of leukocyte ...
Source: Current Medicinal Chemistry - December 28, 2013 Category: Chemistry Authors: Rodriguesa SF, Grangerb DN Tags: Curr Med Chem Source Type: research

Prognostic Value of Inflammatory and Cardiovascular Biomarkers for Prediction of 90-Day All-Cause Mortality after Acute Ischemic Stroke--Results from the Linz Stroke Unit Study Proteomics and Protein Markers
CONCLUSIONS: In this large cohort of patients with acute ischemic stroke, IL-6 and NT-proBNP at admission were strong and independent prognostic markers for 90-day all-cause mortality, and provided complementary prognostic information to the routinely used stroke severity score NIHSS.
Source: Clinical Chemistry - May 26, 2017 Category: Chemistry Authors: Dieplinger, B., Bocksrucker, C., Egger, M., Eggers, C., Haltmayer, M., Mueller, T. Tags: Proteomics and Protein Markers Source Type: research

Multi-modal imaging of long term recovery post-stroke by PET and MALDI-MS.
CONCLUSIONS: The data demonstrates the ability to combine MALD-MS with in vivo PET to image different aspects of stroke recovery. PMID: 29484723 [PubMed - as supplied by publisher]
Source: Rapid Communications in Mass Spectrometry : RCM - February 27, 2018 Category: Chemistry Authors: Henderson F, Hart PJ, Pradillo JM, Kassiou M, Christie L, Williams KJ, Boutin H, McMahon A Tags: Rapid Commun Mass Spectrom Source Type: research

Novel potent antiplatelet thrombotic agent derived from biguanide for ischemic stroke.
Abstract Platelet thrombosis is the main pathogeny resulting in the low curability of ischemic stroke, a leading cause of mortality and disability worldwide. Metformin, a biguanide derivative that is the first-line oral medicine for type 2 diabetes, alleviates the severity of ischemic stroke in diabetic patients and suppresses platelet activation in experimental animal model. However, the clinical implementation of commercial biguanide analogs for stroke related to platelet thrombosis remains challenging due to its weak potency, poor pharmacokinetic characteristics and possible hypoglycemia. Here, twenty-three big...
Source: European Journal of Medicinal Chemistry - May 17, 2020 Category: Chemistry Authors: Xin G, Ming Y, Ji C, Wei Z, Li S, Morris-Natschke SL, Zhang X, Yu K, Li Y, Zhang B, Zhang J, Xing Z, He Y, Chen Z, Yang X, Niu H, Lee KH, Huang W Tags: Eur J Med Chem Source Type: research

Molecules, Vol. 26, Pages 5001: The Nrf2 Pathway in Ischemic Stroke: A Review
ano Saso Ischemic stroke, characterized by the sudden loss of blood flow in specific area(s) of the brain, is the leading cause of permanent disability and is among the leading causes of death worldwide. The only approved pharmacological treatment for acute ischemic stroke (intravenous thrombolysis with recombinant tissue plasminogen activator) has significant clinical limitations and does not consider the complex set of events taking place after the onset of ischemic stroke (ischemic cascade), which is characterized by significant pro-oxidative events. The transcription factor Nuclear factor erythroid 2-related factor...
Source: Molecules - August 18, 2021 Category: Chemistry Authors: Marcelo Farina Leonardo Eug ênio Vieira Brigitta Buttari Elisabetta Profumo Luciano Saso Tags: Review Source Type: research

The emerging role of microRNA in stroke.
Abstract MicroRNAs (miRNAs) are small non-coding RNAs approximately 22 nucleotides in length that play a pivotal role in post-transcriptional gene regulation by binding to complementary sites in the 3'-untranslated region of messenger RNAs. In the past decade, their role in several human diseases, from cancer to cardiovascular disease, has been established by a wealth of evidence. Stroke is responsible for 10% of deaths worldwide and is one of the leading causes of disability. MiRNAs are involved in stroke risk factors including hypertension, atherosclerosis, atrial fibrillation, diabetes and dyslipidemia. The rol...
Source: Current Topics in Medicinal Chemistry - May 31, 2013 Category: Chemistry Authors: Koutsis G, Siasos G, Spengos K Tags: Curr Top Med Chem Source Type: research