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Specialty: Neurology
Condition: Ischemic Stroke
Education: Study

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Total 11683 results found since Jan 2013.

The influence of COVID-19 on the treatment of patients with acute ischemic stroke: a  retrospective observational study
CONCLUSIONS: The pandemic situation of COVID-19 significantly reduced the number of patients with AIS and prolonged the travel time to the hospital whereas most of the stroke treatment services were maintained.PMID:37587891 | DOI:10.5114/fn.2023.124565
Source: Folia Neuropathologica - August 17, 2023 Category: Neurology Authors: Wei Chen Fangju Lin Wei Zhao Baoling Yang Weihua Jia Source Type: research

Lesion location and serum levels of homocysteine are associated with early ‐onset post‐stroke depression in acute ischemic stroke
ConclusionsOur study indicated that higher NIHSS score, elevated serum levels of HCY, and multiple-site lesions may be independent risk factors of early-onset PSD. The combination of HCY, NIHSS scores, multiple-site lesions, and lesion location may provide greater predictive value than HCY alone for early-onset PSD. Early intervention for elevated serum levels of HCY may be a potential target for the intervention and prevention of PSD.
Source: Brain and Behavior - August 17, 2023 Category: Neurology Authors: Hongxu Zhou, Chenlong Wang, Wei Wang, Hongyan Li, Qun Hu, Ni Huang, Yining Huang Tags: ORIGINAL ARTICLE Source Type: research

Regular pulse checks for patients with non-cardioembolic stroke in rehabilitation hospitals to improve recognition and detection of atrial fibrillation (the ESCORT study): protocol for a prospective multicenter observational study
ConclusionThe findings of this study will help identify patients with AF in rehabilitation hospitals and improve awareness among therapists.
Source: Frontiers in Neurology - August 16, 2023 Category: Neurology Source Type: research

Intravenous thrombolysis and endovascular therapy for acute ischemic stroke in COVID-19: a systematic review and meta-analysis
ConclusionCOVID-19 appears to have an adverse impact on acute ischemic stroke patients who undergo reperfusion therapy, leading to an elevated risk of any ICH, higher mortality and lower likelihood of favorable functional outcome.Systematic review registrationhttps://clinicaltrials.gov/, identifier CRD42022309785.
Source: Frontiers in Neurology - August 15, 2023 Category: Neurology Source Type: research

miR-188-5p silencing improves cerebral ischemia/reperfusion injury by targeting Lin28a
This report aimed to explore whether miR-188-5p regulated the pathological regulatory network of cerebral ischemia/reperfusion (I/R) injury. We simulated the cerebral I/R injury model with MACO/R and OGD/R treatments. Neuronal viability and apoptosis were assessed. The contents of miR-188-5p and Lin 28a were evaluated. The abundances of apoptosis-related proteins (Bax, Bcl-2, and cleaved caspase-3) and pro-inflammatory cytokines (TNF- α, IL-1β, and IL-6) were measured. The interaction of miR-188-5p and Lin28a was confirmed. Lin28a silencing was supplemented to determine the delicate regulation of miR-188-5p. We revealed ...
Source: Metabolic Brain Disease - August 12, 2023 Category: Neurology Source Type: research

Skin capillary amylin deposition resembles brain amylin vasculopathy in rats
Human amylin is a 37 amino-acid pancreatic peptide that forms neuro-toxic aggregates that deposit in the endothelium of brain capillaries of patients with diabetes, potentially contributing to cerebral small vessel ischemic injury. Pathogenic amylin also deposits in the capillary endothelium in other organs, including the skin. The aim of this study was to test the hypothesis that skin capillary amylin deposition correlates with cerebral small vessel amylin deposition, potentially providing a clinically useful marker of cerebral amylin deposition.
Source: Journal of Stroke and Cerebrovascular Diseases - August 11, 2023 Category: Neurology Authors: Saurav Das, Nirmal Verma, Larry B. Goldstein, Florin Despa Source Type: research

Ticagrelor versus clopidogrel after intracranial stent angioplasty: a real-world study
ConclusionIn our study involving patients with acute ischemic stroke who had undergone intracranial stenting, aspirin-ticagrelor was not found to be superior to aspirin-clopidogrel in reducing the rate of ischemic vascular events. The risk of bleeding did not differ between the two groups. Aspirin-ticagrelor does not lower total restenosis and symptomatic restenosis risk at follow-up.
Source: Frontiers in Neurology - August 11, 2023 Category: Neurology Source Type: research

Ipsilateral and contralateral carotid stenosis contribute to the outcome of reperfusion treatment for ischemic stroke
DiscussionAccording to our findings, ICS and CCS negatively influence AIS patients' outcome treated by interventional therapies. ICS might exert an unfavorable effect both by cerebral hypoperfusion and by continuous microembolization toward ischemic area, while CCS is probable involved in reducing the collateral circles effectiveness. The importance of early carotid stenosis detection and treatment should then be reevaluated not only to manage the prevention approaches but also to obtain insights about post-stroke treatment strategies efficacy.
Source: Frontiers in Neurology - August 10, 2023 Category: Neurology Source Type: research

Endovascular Treatment for Acute Ischemic Stroke in China: a study protocol for a prospective, national, multi-center, registry study
This study plans to enroll a total of 3,000 consecutive patients who received EVT for LVO. All eligible patients are adults aged 18 years or older with acute LVO who received EVT and standard medical treatment according to the Chinese stroke guidelines and local practice.OutcomeThe primary outcome is functional independence (modified Rankin Scale score, mRS ≤ 2) at 90 days. The secondary outcomes include (1) the proportion of patients with mRS scores of 0–1 at 90 days, (2) distribution of mRS at 90 days, (3) changes in National Institutes of Health stroke scale (NIHSS) at 24 h, 48 h, and 12 days or discharge (whichever...
Source: Frontiers in Neurology - August 10, 2023 Category: Neurology Source Type: research

Application of Nanozymes and its Progress in the Treatment of Ischemic Stroke
AbstractNanozymes are a new kind of material which has been applied since the beginning of this century, and its birth has promoted the development of chemistry, materials science, and biology. Nanozymes can be used as a substitute for natural enzyme and has a wide range of applications; therefore, it has attracted extensive attention from all sectors of the community, and the number of studies has constantly increasing. In this paper, we introduced the outstanding achievements in the field of nanozymes in recent years from the main function, the construction of nanozyme-based biosensors, and the treatment of ischemic stro...
Source: Translational Stroke Research - August 9, 2023 Category: Neurology Source Type: research