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Clinical outcomes of secondary prevention strategies for young patients with cryptogenic stroke and patent foramen ovale.
Conclusions The diagnosis of stroke in patients with PFO could be confirmed in 50% of cases only, underlining the importance of a multidisciplinary evaluation of these patients. A very low ischaemic recurrence rate was observed in the medical therapy group, suggesting that a personalized treatment based on a prespecified diagnostic algorithm yields good clinical results irrespective of the treatment modality. Given the low number of recurrences, larger cohorts may be needed to prove significant differences. PMID: 28705105 [PubMed - as supplied by publisher]
Source: Acta Cardiologica - July 15, 2017 Category: Cardiology Tags: Acta Cardiol Source Type: research

The dispersion of myocardial repolarization in ischemic stroke and intracranial hemorrhage
Markers of dispersion of myocardial repolarization have been proposed to identify the patients at higher risk of malignant arrhythmic events. The aim of the present study is to assess a possible association of the electrocardiografic (ECG) markers of the dispersion of repolarization with the type of stroke, involvement of insula, neurological severity (National Institutes of Health Stroke Scale, NIHSS score), and disability (modified Rankin Scale, mRS score) in patients with a cerebrovascular event.
Source: Journal of Electrocardiology - May 17, 2018 Category: Cardiology Authors: Alessandra Danese, Manuel Cappellari, Elia Pancheri, Giacomo Mugnai, Nicola Micheletti, Giampaolo Tomelleri, Monica Carletti, Giulia Turri, Vincenzo Marafioti, Salvatore Monaco, Bruno Bonetti, Paolo Bovi Source Type: research

P155/200 Usefulness of quadri-axial system in mechanical thrombectomy in acute ischemic stroke: redefining the boundaries of trans-femoral access
ConclusionQAS via TFA for MT in AIS is a safe and effective technique, even in challenging cases, allowing faster and more successful procedures without increasing complications. QAS could redefine and widen the boundaries of TFA in AIS.Disclosure of InterestNothing to disclose.
Source: Journal of NeuroInterventional Surgery - August 21, 2023 Category: Neurosurgery Authors: Politi, M. A., Kuncha, G., Conte, M., Cavallaro, T., Corsale, G., Borzi, S. R., Monaco, E., Travali, M., Concetto, C. Tags: 2.3 ISCHEMIC - Treatment Source Type: research

The benefit of radiosurgery for ARUBA-eligible arteriovenous malformations: a practical analysis over an appropriate follow-up period.
CONCLUSIONS After a sensible follow-up period exceeding the latency period, there is a lower rate of stroke/death for patients with treated, unruptured AVMs with SRS than for patients with untreated AVMs. PMID: 28665253 [PubMed - as supplied by publisher]
Source: Journal of Neurosurgery - June 30, 2017 Category: Neurosurgery Authors: Tonetti DA, Gross BA, Atcheson KM, Jankowitz BT, Kano H, Monaco EA, Niranjan A, Flickinger JC, Lunsford LD Tags: J Neurosurg Source Type: research

Prolonged QTc interval and Insula in patients with ischemic stroke: Inductive or abductive reasoning?
While a great emphasis has been placed on pathophysiological mechanisms underlying the long QT syndromes (LQTS), both congenital and acquired forms, little attention has been focused on the mechanisms whereby a brain damage could induce changes in the QTc interval. Until now, there has been no precise explanation for the frequently observed relationship between acute cerebrovascular events and QTc interval prolongation. Many excellent studies with inductive reasoning proposed QTc effects of insular cortex stimulation [1,2] Few and controversial studies with abductive reasoning investigated an association between prolonged ...
Source: International Journal of Cardiology - August 4, 2014 Category: Cardiology Authors: Vincenzo Marafioti, Giulia Turri, Andrea Rossi, Vincenzo Carbone, Salvatore Monaco, Corrado Vassanelli Source Type: research

Prolonged QTc interval and insula in patients with ischemic stroke: Inductive or abductive reasoning?
While a great emphasis has been placed on pathophysiological mechanisms underlying the long QT syndromes (LQTS), both congenital and acquired forms, little attention has been focused on the mechanisms whereby a brain damage could induce changes in the QTc interval. Until now, there has been no precise explanation for the frequently observed relationship between acute cerebrovascular events and QTc interval prolongation. Many excellent studies with inductive reasoning proposed QTc effects of insular cortex stimulation [1,2] Few and controversial studies with abductive reasoning investigated an association between prolonged ...
Source: International Journal of Cardiology - August 4, 2014 Category: Cardiology Authors: Vincenzo Marafioti, Giulia Turri, Andrea Rossi, Salvatore Monaco, Vincenzo Carbone Tags: Letter to the Editor Source Type: research

Prevalence, incidence and mortality from cardiovascular disease in patients with pooled and specific severe mental illness: a large-scale meta-analysis of 3,211,768 patients and 113,383,368 controls.
Abstract People with severe mental illness (SMI) - schizophrenia, bipolar disorder and major depressive disorder - appear at risk for cardiovascular disease (CVD), but a comprehensive meta-analysis is lacking. We conducted a large-scale meta-analysis assessing the prevalence and incidence of CVD; coronary heart disease; stroke, transient ischemic attack or cerebrovascular disease; congestive heart failure; peripheral vascular disease; and CVD-related death in SMI patients (N=3,211,768) versus controls (N=113,383,368) (92 studies). The pooled CVD prevalence in SMI patients (mean age 50 years) was 9.9% (95% CI: 7.4-...
Source: World Psychiatry - May 13, 2017 Category: Psychiatry Authors: Correll CU, Solmi M, Veronese N, Bortolato B, Rosson S, Santonastaso P, Thapa-Chhetri N, Fornaro M, Gallicchio D, Collantoni E, Pigato G, Favaro A, Monaco F, Kohler C, Vancampfort D, Ward PB, Gaughran F, Carvalho AF, Stubbs B Tags: World Psychiatry Source Type: research

Inflammation and Atrial Electrical Remodeling in Patients With Embolic Strokes of Undetermined Source
About one third of ischaemic strokes are classified as embolic strokes of undetermined source (ESUS). A silent atrial fibrillation (AF) may play a pathogenic role in these strokes and P wave dispersion (PWD), representing an electrocardiograph (ECG) predictor for paroxysmal AF, thereby a potential marker of covert cardioembolism, was found to be increased in cryptogenic stroke. Furthermore, current evidence links AF to inflammation: inflammatory markers, such as high-sensitive C-reactive protein (hsCRP), have been related to the development and persistence of AF, possibly by promoting atrial remodelling.
Source: Heart, Lung and Circulation - May 8, 2018 Category: Cardiology Authors: Maurizio Acampa, Pietro Enea Lazzerini, Francesca Guideri, Rossana Tassi, Andrea Lo Monaco, Giuseppe Martini Tags: Original Article Source Type: research

Inflammation and Atrial Electrical Remodelling in Patients With Embolic Strokes of Undetermined Source
About one third of ischaemic strokes are classified as embolic strokes of undetermined source (ESUS). A silent atrial fibrillation (AF) may play a pathogenic role in these strokes and P wave dispersion (PWD), representing an electrocardiographic (ECG) predictor for paroxysmal AF, thereby a potential marker of covert cardioembolism, was found to be increased in cryptogenic stroke. Furthermore, current evidence links AF to inflammation: inflammatory markers, such as high-sensitive C-reactive protein (hsCRP), have been related to the development and persistence of AF, possibly by promoting atrial remodelling.
Source: Heart, Lung and Circulation - May 7, 2018 Category: Cardiology Authors: Maurizio Acampa, Pietro Enea Lazzerini, Francesca Guideri, Rossana Tassi, Andrea Lo Monaco, Giuseppe Martini Tags: Original Article Source Type: research

The changing landscape of the vulnerable plaque: A call for fine-tuning of preclinical models
Vascul Pharmacol. 2021 Oct 1:106924. doi: 10.1016/j.vph.2021.106924. Online ahead of print.ABSTRACTFor decades, the pathological definition of the vulnerable plaque led to invaluable insights into the mechanisms that underlie myocardial infarction and stroke. Beyond plaque rupture, other mechanisms, such as erosion, may elicit thrombotic events underlining the complexity and diversity of the atherosclerotic disease. Novel insights, based on single-cell transcriptomics and other "omics" methods, provide tremendous opportunities in the ongoing search for cell-specific determinants that will fine-tune the description of the t...
Source: Vascular Pharmacology - October 4, 2021 Category: Drugs & Pharmacology Authors: Michele F Buono Lotte Slenders Marian Wesseling Robin J G Hartman Claudia Monaco Hester M den Ruijter Gerard Pasterkamp Michal Mokry Source Type: research