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Condition: Ischemic Stroke

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Total 193 results found since Jan 2013.

DL-3-n-butylphthalide prevents oxidative stress and atherosclerosis by targeting Keap-1 and inhibiting Keap-1/Nrf-2 interaction
Eur J Pharm Sci. 2022 Mar 5:106164. doi: 10.1016/j.ejps.2022.106164. Online ahead of print.ABSTRACTAtherosclerosis is the common pathophysiological foundation of ischaemic stroke and myocardial ischaemia. Oxidative stress is intricately related to the progress of atherosclerosis. DL-3-n-butylphthalide (NBP) is a synthesized raceme of L-3-n-butylphthalide that is first isolated from celery. As a neuroprotective agent, NBP also exhibits potent antioxidative activity. Our research aimed to evaluate the effect of NBP on atherosclerosis and to explore the underlying antioxidative mechanisms and targets. Firstly, we detected the...
Source: European Journal of Pharmaceutical Sciences - March 8, 2022 Category: Drugs & Pharmacology Authors: Jibo Han Xiaowen Shi Jiajun Xu Wante Lin Yanghao Chen Bingjiang Han Yi Wang Jianjiang Xu Source Type: research

Long non-coding RNA H19 promotes leukocyte inflammation in ischemic stroke by targeting the miR-29b/C1QTNF6 axis
CONCLUSIONS: Our findings confirm that H19 promotes leukocyte inflammation by targeting the miR-29b/C1QTNF6 axis in cerebral ischemic injury.PMID:35322553 | DOI:10.1111/cns.13829
Source: CNS Neuroscience and Therapeutics - March 24, 2022 Category: Neuroscience Authors: Guangwen Li Xiaoqing Ma Haiping Zhao Junfen Fan Tianwei Liu Yumin Luo Yunliang Guo Source Type: research

Acute Administration of Metformin Protects Against Neuronal Apoptosis Induced by Cerebral Ischemia-Reperfusion Injury via Regulation of the AMPK/CREB/BDNF Pathway
Metformin is a first-line anti-diabetic agent with a powerful hypoglycemic effect. Several studies have reported that metformin can improve the prognosis of stroke patients and that this effect is independent of its hypoglycemic effect; however, the specific mechanism remains unclear. In this research, we explored the effect and specific mechanism of metformin in cerebral ischemia-reperfusion (I/R) injury by constructing a transient middle cerebral artery occlusion model in vivo and a glucose and oxygen deprivation/reoxygenation (OGD/R) model in vitro. The results of the in vivo experiments showed that acute treatment with...
Source: Frontiers in Pharmacology - April 1, 2022 Category: Drugs & Pharmacology Source Type: research

Non-mitogenic fibroblast growth factor 1 protects against ischemic stroke by regulating microglia/macrophage polarization through Nrf2 and NF- κB pathways
Neuropharmacology. 2022 Apr 19:109064. doi: 10.1016/j.neuropharm.2022.109064. Online ahead of print.ABSTRACTMicroglia are immune cells in the central nervous system (CNS) that participate in response to pathological process after ischemic injury. Non-mitogenic fibroblast growth factor 1 (nmFGF1) is an effective neuroprotective factor that is also known as a metabolic regulator. The present study aimed to investigate the effects and mechanism of the neuroprotective ability of nmFGF1 on microglia in mice after photothrombosis (PT) stroke model, to determine whether it could ameliorate ischemic injury in stroke experiment. We...
Source: Neuropharmacology - April 22, 2022 Category: Drugs & Pharmacology Authors: Confidence Dordoe Xue Wang Ping Lin Zhengyi Wang Jian Hu Dongxue Wang Yani Fang Fei Liang Shasha Ye Jun Chen Yeli Zhao Ye Xiong Yunjun Yang Li Lin Xianfeng Li Source Type: research

Cyclo-(Phe-Tyr) as a novel cyclic dipeptide compound alleviated ischemic stroke reperfusion brain injury via JUNB/JNK/NF- κB and SOX5/PI3K/AKT pathways
Pharmacol Res. 2022 Apr 25:106230. doi: 10.1016/j.phrs.2022.106230. Online ahead of print.ABSTRACTIschemic stroke reperfusion (IR) can cause adverse reactions including apoptosis, oxidative stress, and inflammation, but the existing therapeutic strategies have been limited. Moreover, the regulation of microglia plays an important role in brain injury after reperfusion. Hence, it is imperative to find new and effective drugs for modulating microglia to treat IR brain injury. Cyclic peptide compound cyclo-(Phe-Tyr) (Sparganin C, SC) is a compound isolated from Sparganii Rhizoma. However, the protective effects of SC on the c...
Source: Cell Research - April 28, 2022 Category: Cytology Authors: Jiale Cai Jiayin Liang Yutong Zhang Lin Shen Huiting Lin Tao Hu Sikai Zhan Meixia Xie Shengwang Liang Minghua Xian Shumei Wang Source Type: research

LncRNA PEG11as silencing sponges miR-874-3p to alleviate cerebral ischemia stroke via regulating autophagy < em > in vivo < /em > and < em > in vitro < /em >
Aging (Albany NY). 2022 Jun 24;14(undefined). doi: 10.18632/aging.204140. Online ahead of print.ABSTRACTLong non-coding RNAs (lncRNAs) are reportedly involved in the regulation of physiological and pathophysiological processes. However, the potential role of lncRNAs in stroke remains largely undefined. Here, RNA-Seq analysis of lncRNAs found that the lncRNA PEG11as (PEG11as) levels were significantly increased in ischemic brain tissue in a transient middle cerebral artery occlusion/reperfusion (tMCAO/R) mouse model of stroke. To explore the role of PEG11as in stroke, the lentivirus containing PEG11as silencing construct(si...
Source: Aging - June 24, 2022 Category: Biomedical Science Authors: Xiamin Hu Fuyun Ma Zhongliang Cheng Suyou Zeng Ruling Shen Xuan Li Junqi Hu Zhigang Jin Jinping Cheng Source Type: research

Retinoic Acid Prevents the Neuronal Damage Through the Regulation of Parvalbumin in an Ischemic Stroke Model
In conclusion, retinoic acid contributes to the preservation of neurons from ischemic stroke by controlling parvalbumin expression and apoptosis-related proteins.PMID:36245066 | DOI:10.1007/s11064-022-03769-9
Source: Neurochemical Research - October 16, 2022 Category: Neuroscience Authors: Ju-Bin Kang Dong-Ju Park Phil-Ok Koh Source Type: research

Cycloastragenol suppresses M1 and promotes M2 polarization in LPS-stimulated BV-2 cells and ischemic stroke mice
This study investigated the effect of CAG on the phenotype polarization of microglia in lipopolysaccharide (LPS)-stimulated BV-2 mouse microglial cells and ischemic stroke mice. In LPS-treated BV-2 cells, we found that CAG significantly reduced the expression of M1 markers, including pro-inflammatory cytokines and enzymes. In contrast, CAG promoted the expression of M2 markers, including anti-inflammatory cytokines and growth factor. In addition, CAG inhibited the activation of nuclear factor-κB (NF-κB) and enhanced the activation of nuclear factor E2-related factor 2 (Nrf2) and the expression of its downstream heme oxyg...
Source: International Immunopharmacology - October 17, 2022 Category: Allergy & Immunology Authors: Ting Chen Ziqing Li Shichun Li Yingxiang Zou Xinyi Gao Shi Shu Zhifei Wang Source Type: research

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