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Precision medicine in allergic disease —food allergy, drug allergy, and anaphylaxis—PRACTALL document of the European Academy of Allergy and Clinical Immunology and the American Academy of Allergy, Asthma and Immunology
Abstract This consensus document summarizes the current knowledge on the potential for precision medicine in food allergy, drug allergy, and anaphylaxis under the auspices of the PRACTALL collaboration platform. PRACTALL is a joint effort of the European Academy of Allergy and Clinical Immunology and the American Academy of Allergy, Asthma and Immunology, which aims to synchronize the European and American approaches to allergy care. Precision medicine is an emerging approach for disease treatment based on disease endotypes, which are phenotypic subclasses associated with specific mechanisms underlying the disease. Althoug...
Source: Allergy - April 12, 2017 Category: Allergy & Immunology Authors: A. Muraro, R. F. Lemanske, M. Castells, M. J. Torres, D. Khan, H. ‐U. Simon, C. Bindslev‐Jensen, W. Burks, L. K. Poulsen, H. A. Sampson, M. Worm, K. C. Nadeau Tags: Review Article Source Type: research

Radiocontrast media hypersensitivity: skin testing differentiates allergy from non-allergic reactions and identifies a safe alternative as proven by intravenous provocation
ConclusionsThe diagnostic sensitivity of intradermal RCM testing to identify allergic patients is high in both, immediate-type and delayed-type RCM allergy. Intravenous provocation with a skin test-negative RCM is safe and enables identification of a tolerated alternative RCM. Additional skin testing of iodine solution is required to identify patients with iodine allergy.
Source: The Journal of Allergy and Clinical Immunology: In Practice - April 12, 2019 Category: Allergy & Immunology Source Type: research

Radiocontrast Media Hypersensitivity: Skin Testing Differentiates Allergy From Nonallergic Reactions and Identifies a Safe Alternative as Proven by Intravenous Provocation
ConclusionsThe diagnostic sensitivity of intradermal RCM testing to identify allergic patients is high in both immediate-type and delayed-type RCM allergy. Intravenous provocation with a skin test–negative RCM is safe and enables identification of a tolerated alternative RCM. Additional skin testing of iodine solution is required to identify patients with iodine allergy.
Source: The Journal of Allergy and Clinical Immunology: In Practice - May 9, 2019 Category: Allergy & Immunology Source Type: research

Food allergy knowledge of parents – is ignorance bliss?
ConclusionsFood allergy knowledge among parents of food allergic children from the Netherlands is suboptimal when compared with their counterparts from the USA, although these parents tend to be more optimistic toward food allergy than parents from the USA.
Source: Pediatric Allergy and Immunology - June 1, 2013 Category: Allergy & Immunology Authors: Nicole J. Goossens, Bertine M. J. Flokstra‐de Blok, Gerbrich N. Meulen, Erna Botjes, Hans G. M. Burgerhof, Ruchi S. Gupta, Elizabeth E. Springston, Bridget Smith, Eric J. Duiverman, Anthony E. J. Dubois Tags: Original Article Source Type: research

Systematic review on cashew nut allergy
Abstract Recent studies on cashew nut allergy suggest that the prevalence of cashew nut allergy is increasing. Cashew nut consumption by allergic patients can cause severe reactions, including anaphylaxis. This review summarizes current knowledge on cashew nut allergy to facilitate timely clinical recognition and to promote awareness of this emerging food allergy amongst clinicians. The goal of this study is to present a systematic review focused on the clinical aspects of allergy to cashew nut including the characteristics of cashew nut, the prevalence, allergenic components, cross‐reactivity, diagnosis and management o...
Source: Allergy - April 15, 2014 Category: Allergy & Immunology Authors: J. P. M. Valk, A. E. J. Dubois, R. Gerth van Wijk, H. J. Wichers, N. W. Jong Tags: Review Article Source Type: research

Shellfish and House Dust Mite Allergies: Is the Link Tropomyosin?
Authors: Wong L, Huang CH, Lee BW Abstract Crustacean shellfish allergy is an important cause of food allergy and anaphylaxis in Asia. The major allergen in shellfish allergy is tropomyosin, a pan-allergen that is also found in house dust mites and cockroaches. Tropomyosins from house dust mites (HDMs) have a high sequence homology to shellfish tropomyosins, and cross-reactivity between HDM and shrimp tropomyosins has been demonstrated. Exposure to inhaled tropomyosins from house dust mites has been postulated to be the primary sensitizer for shellfish allergy, in a reaction analogous to the oral allergy (inhalant-...
Source: Allergy, Asthma and Immunology Research - January 16, 2016 Category: Allergy & Immunology Tags: Allergy Asthma Immunol Res Source Type: research

Comparison of the Performance of Skin Prick, ImmunoCAP, and ISAC Tests in the Diagnosis of Patients with Allergy
Conclusions: In this difficult diagnostic group, the ImmunoCAP test should be the preferred single test for possible allergy to nuts, wheat, other specific foods, and anaphylaxis of any cause. In these conditions, SPT and ISAC tests give comparable results. The most useful single test for oral allergy syndrome is ISAC, and SPT should be the preferred test for latex allergy.Int Arch Allergy Immunol 2017;172:215-223
Source: International Archives of Allergy and Immunology - April 28, 2017 Category: Allergy & Immunology Source Type: research

National clinical practice guidelines for food allergy and anaphylaxis: an international assessment
ConclusionsThis study concludes that the overwhelming majority of countries do not have any national clinical practice guidelines for food allergy or anaphylaxis.
Source: Clinical and Translational Allergy - July 25, 2017 Category: Allergy & Immunology Source Type: research

The Cost of Penicillin Allergy Evaluation
Conclusions Using TDABC, penicillin allergy evaluation costs $220; even with varied assumptions adjusting for operational challenges, clinical setting, and expanded testing, penicillin allergy evaluation still costs only about $540. This modest investment may be offset for patients treated with costly alternative antibiotics that also may result in adverse consequences.
Source: The Journal of Allergy and Clinical Immunology: In Practice - September 22, 2017 Category: Allergy & Immunology Source Type: research

Asthma, Family History of Drug Allergy, and Age Predict Amoxicillin Allergy in Children
Conclusions Skin prick test did not contribute to the diagnosis of amoxicillin allergy. The presence of asthma, family history of drug allergy, and older age at reaction can be used as predictive factors for true amoxicillin allergy in children.
Source: The Journal of Allergy and Clinical Immunology: In Practice - December 16, 2017 Category: Allergy & Immunology Source Type: research

Risk Factors for Food Allergy in Early Adolescence: The SchoolNuts Study
Conclusions Early-onset eczema, Asian background, and family history of allergic disease were associated with an increased risk of food allergy, whereas dog exposure in early life reduced the risk in 10- to14-year-old adolescents. Factors predicting food allergy risk in an adolescent population-based cohort appear remarkably similar to those predicting early-onset food allergy in infancy.
Source: The Journal of Allergy and Clinical Immunology: In Practice - February 2, 2018 Category: Allergy & Immunology Source Type: research

Asthma, Family History of Drug Allergy, and Age Predict Amoxicillin Allergy in Children
ConclusionsSkin prick test did not contribute to the diagnosis of amoxicillin allergy. The presence of asthma, family history of drug allergy, and older age at reaction can be used as predictive factors for true amoxicillin allergy in children.
Source: The Journal of Allergy and Clinical Immunology: In Practice - July 5, 2018 Category: Allergy & Immunology Source Type: research

Food Allergy and Asthma: Is There a Link?
AbstractPurpose of reviewTo describe and understand the links and interactions between food allergy and asthmaRecent findingsFood allergy and asthma are characterized by an increasing prevalence. Moreover, food allergy and asthma often coexist. Both conditions are associated with each other in different ways. It has been shown that food allergy is a risk factor of developing asthma. Atopic dermatitis appears to be the common denominator in this interaction. Loss-of-function variants of the filaggrin mutation result in an impaired epidermal barrier function and have been shown to be a risk factor for the development of atop...
Source: Current Treatment Options in Allergy - October 1, 2018 Category: Allergy & Immunology Source Type: research