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Condition: SARS
Therapy: Immunotherapy
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Total 390 results found since Jan 2013.
How does the Immunological System Change during the SARS-COV-2 Attack? A Clue for the New Immunotherapy Discovery
Curr Med Chem. 2023 Sep 18. doi: 10.2174/0929867331666230918092749. Online ahead of print.ABSTRACTThe COVID-19 pandemic caused by the Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-COV-2) is one of the biggest unsolved global problems of the 21st century for which there has been no definitive cure yet. Like other respiratory viruses, SARS-COV-2 triggers the host immunity dramatically, causing dysfunction in the immune system, both innate and adaptive, which is a common feature of COVID-19 patients. Evidence shows that in the early stages of COVID-19, the immune system is suppressed while it is overactive in severe p...
Source: Current Medicinal Chemistry - September 19, 2023 Category: Chemistry Authors: Mohammad Mahdi Hajihasani Najmeh Kaffash Farkhad Ali Mahmoudi Amirhossein Sahebkar Source Type: research
Stimuli-Responsive Hydrogel Microcapsules Harnessing the COVID-19 Immune Response for Cancer Therapeutics
We present the development of stimuli-responsive microcapsules, loaded with a viral immunogenetic agent, harnessing the immune response against the Coronavirus Disease 2019, COVID-19, to selectively attack liver cancer cells (hepatoma) or recognize breast cancer or hepatoma, by expression of green fluorescence protein, GFP. The pH-responsive microcapsules, modified with DNA-tetrahedra nanostructures, increased hepatoma permeation by 50%. Incorporation of a GFP-encoding lentivirus vector inside the tumor-targeting pH-stimulated miRNA-triggered and Alpha-fetoprotein-dictated microcapsules enables the demonstration of neoplas...
Source: Angewandte Chemie - September 7, 2023 Category: Chemistry Authors: Amit Fischer Avner Ehrlich Yevgeni Plotkin Yu Ouyang Klil Asulin Ioannidis Konstantinos Chunhai Fan Yaakov Nahmias Itamar Willner Source Type: research
Bioinformatics analysis of carotid vulnerable plaques associated with the SARS-CoV-2 Pattern
Gene. 2023 Aug 31:147754. doi: 10.1016/j.gene.2023.147754. Online ahead of print.ABSTRACTThe rupture of carotid artery vulnerable plaque plays a critical role in ischemic stroke, and the widely spread new coronavirus in recent years plays a certain role in the development of human carotid artery vulnerable plaque, we screened out 27 differential expression genes (DEGs) of stable plaque and vulnerable plaque associated with the new coronavirus. Through the construction of the protein-protein interaction (PPI) network, the Cathepsin B (CTSB) and Niemann-Pick Disease Type 2 (NPC2) were identified as crucial expression genes, ...
Source: Gene - September 2, 2023 Category: Genetics & Stem Cells Authors: Tao Jiang Jiaming Huang Shupeng Li Qiushi Xu Tianding Zhang Xianwei Wang Dong Chen Source Type: research
The Important Role of Interleukin-2 in COVID-19
J Immunol Res. 2023 Aug 22;2023:7097329. doi: 10.1155/2023/7097329. eCollection 2023.ABSTRACTThere is controversial literature about the effects of the interleukin-2 (IL-2) cytokine family in COVID-19 pathogenesis and immunity. So we aimed to identify the potential in the role of the IL-2 family in COVID-19. A narrative review search was done through online databases, including PubMed, Scopus, and Web of Science. The search deadline was up to December 2022. We applied no time limits for the searching strategy. After retrieving articles from the databases, the authors summarized the data into two data extraction tables. The...
Source: Journal of Immunology Research - August 31, 2023 Category: Allergy & Immunology Authors: Leila Ghanbari Naeini Laleh Abbasi Farzaneh Karimi Pajman Kokabian Fahimeh Abdi Abyaneh Delaram Naderi Source Type: research
Plant Viruses as Adjuvants for Next-Generation Vaccines and Immunotherapy
Vaccines (Basel). 2023 Aug 16;11(8):1372. doi: 10.3390/vaccines11081372.ABSTRACTVaccines are the cornerstone of infectious disease control and prevention. The outbreak of SARS-CoV-2 has confirmed the urgent need for a new approach to the design of novel vaccines. Plant viruses and their derivatives are being used increasingly for the development of new medical and biotechnological applications, and this is reflected in a number of preclinical and clinical studies. Plant viruses have a unique combination of features (biosafety, low reactogenicity, inexpensiveness and ease of production, etc.), which determine their potentia...
Source: Cancer Control - August 26, 2023 Category: Cancer & Oncology Authors: Nikolai Nikitin Yuri Vasiliev Angelina Kovalenko Ekaterina Ryabchevskaya Olga Kondakova Ekaterina Evtushenko Olga Karpova Source Type: research
mRNA vaccine in cancer therapy: Current advance and future outlook
Clin Transl Med. 2023 Aug;13(8):e1384. doi: 10.1002/ctm2.1384.ABSTRACTMessenger ribonucleic acid (mRNA) vaccines are a relatively new class of vaccines that have shown great promise in the immunotherapy of a wide variety of infectious diseases and cancer. In the past 2 years, SARS-CoV-2 mRNA vaccines have contributed tremendously against SARS-CoV2, which has prompted the arrival of the mRNA vaccine research boom, especially in the research of cancer vaccines. Compared with conventional cancer vaccines, mRNA vaccines have significant advantages, including efficient production of protective immune responses, relatively low s...
Source: Clinical Breast Cancer - August 24, 2023 Category: Cancer & Oncology Authors: Youhuai Li Mina Wang Xueqiang Peng Yingying Yang Qishuang Chen Jiaxing Liu Qing She Jichao Tan Chuyuan Lou Zehuan Liao Xuexin Li Source Type: research
Case-control study assessing the impact of COVID19 in advanced kidney cancer patients treated with antiangiogenics or immunotherapy: the COVID-REN study
CONCLUSIONS: Kidney cancer patients who developed COVID19 while on systemic therapy required more treatment interruptions and hospitalizations than those non-infected. However, no significant impact on cancer outcome was observed. Also, no difference was seen between cases on antiangiogenics or immunotherapy.PMID:37556096 | DOI:10.1007/s12094-023-03295-2
Source: Cancer Control - August 9, 2023 Category: Cancer & Oncology Authors: Jes ús García-Donas Guillermo de Velasco Rodrigo Madurga Jes ús Chamorro Diana Rosero Olatz Etxaniz Jose Luis P érez-Gracia Álvaro Pinto Diego Cacho Mar ía Barba Pablo Borrega Mart ín Lázaro Laura Rodriguez Laura Villalobos Lourdes Garc ía Andr Source Type: research
Viral escape from NK cell-mediated immunosurveillance: A lesson for cancer immunotherapy?
This article is protected by copyright. All rights reserved.PMID:37526136 | DOI:10.1002/eji.202350465
Source: European Journal of Immunology - August 1, 2023 Category: Allergy & Immunology Authors: Pouria Momayyezi Eleni Bilev Hans-Gustaf Ljunggren Quirin Hammer Source Type: research
