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Condition: Diabetes
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Total 118527 results found since Jan 2013.
Microbiome-targeted interventions for the control of oral-gut dysbiosis and chronic systemic inflammation
Trends Mol Med. 2023 Sep 18:S1471-4914(23)00191-0. doi: 10.1016/j.molmed.2023.08.006. Online ahead of print.ABSTRACTRecent research has confirmed the strong connection between imbalances in the oral and gut microbiome (oral-gut dysbiosis), periodontitis, and inflammatory conditions such as diabetes, Alzheimer's disease, and cardiovascular diseases. Microbiome modulation is crucial for preventing and treating several autoimmune and inflammatory diseases, including periodontitis. However, the causal relationships between the microbiome and its derived metabolites that mediate periodontitis and chronic inflammation constitute...
Source: Molecular Medicine - September 20, 2023 Category: Molecular Biology Authors: Juan Pacheco-Yanes Eric Reynolds Jian Li Eliana Mari ño Source Type: research
Mechanisms of action of incretin receptor based dual- and tri-agonists in pancreatic islets
Am J Physiol Endocrinol Metab. 2023 Sep 20. doi: 10.1152/ajpendo.00236.2023. Online ahead of print.ABSTRACTSimultaneous activation of the incretin G protein coupled receptors via unimolecular dual-receptor agonists (UDRA) has emerged as a new therapeutic approach for type 2 diabetes. Recent studies also advocate triple agonism with molecules also capable of binding the glucagon receptor. In this scoping review we discuss the cellular mechanisms of action (MOA) underlying the actions of these novel and therapeutically important classes of peptide receptor agonists. Clinical efficacy studies of several UDRAs have demonstrate...
Source: American Journal of Physiology. Endocrinology and Metabolism - September 20, 2023 Category: Physiology Authors: Franco Folli Giovanna Finzi Roberto Manfrini Alessandra Galli Francesca Casiraghi Lucia Centofanti Cesare Berra Paolo Fiorina Alberto Davalli Stefano La Rosa Carla Perego Paul B Higgins Source Type: research
Endoplasmic Reticulum Stress in Pancreatic β-Cells Induces Incretin Desensitization and β-Cell Dysfunction via ATF4-Mediated PDE4D Expression
Am J Physiol Endocrinol Metab. 2023 Sep 20. doi: 10.1152/ajpendo.00156.2023. Online ahead of print.ABSTRACTPancreatic β-cell dysfunction and eventual loss are key steps in the progression of type 2 diabetes (T2D). Endoplasmic reticulum (ER) stress responses, especially those mediated by the PERK-ATF4 pathway, have been implicated in promoting these β-cell pathologies. However, the exact molecular events surrounding the role of the PERK-ATF4 pathway in β-cell dysfunction remain unknown. Here, we report our discovery that ATF4 promotes the expression of PDE4D, which disrupts β-cell function via a downregulation of cAMP s...
Source: American Journal of Physiology. Endocrinology and Metabolism - September 20, 2023 Category: Physiology Authors: Ji-Hye Lee Hanguk Ryu Hyejin Lee Hye Ram Yu Yurong Gao Kyeong-Min Lee Young-Joon Kim Jaemin Lee Source Type: research
Health of people with selected citizenships in Germany: prevalence of non-communicable diseases and associated social as well as migration-related factors
DISCUSSION: Given the importance of subjective sense of belonging to the society in Germany and self-reported experience of discrimination for the health outcomes studied, the results point to health inequalities among people with selected citizenships that may indicate mechanisms of social exclusion.PMID:37728772 | DOI:10.1007/s00103-023-03767-4
Source: Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz - September 20, 2023 Category: International Medicine & Public Health Authors: Susanne Bartig Marleen Bug Carmen Koschollek Katja Kajikhina Miriam Blume Manuel Siegert Christin Heidemann Lena Walther Hannelore Neuhauser Claudia H övener Source Type: research
Hyperpolarized 1- < sup > 13 < /sup > Cpyruvate Magnetic Resonance Spectroscopy Shows That Agmatine Increased Lactate Production in the Brain of Type 2 Diabetic Mice
CONCLUSION: Agmatine influences the NADH/NAD+ redox state in the brains of T2DM mice, which may be connected with enhanced cognitive performance and increased conversion of HP [1-13C]pyruvate to HP [1-13C]lactate.PMID:37727922 | DOI:10.3349/ymj.2022.0554
Source: Yonsei Medical Journal - September 20, 2023 Category: Universities & Medical Training Authors: Young-Suk Choi Jae Eun Song Eosu Kim Chul Hoon Kim Jong Eun Lee Ho-Taek Song Source Type: research
Subclinical hypothyroidism in children and adolescents as mild dysfunction of the thyroid gland: a single-center study
Pediatr Endocrinol Diabetes Metab. 2023;29(2):97-103. doi: 10.5114/pedm.2023.124266.ABSTRACTINTRODUCTION: Subclinical hypothyroidism (SH) is a biochemical diagnosis made when a serum thyroid-stimulating hormone (TSH) is ele-vated with circulating thyroid hormone levels within their reference ranges.AIM OF THE STUDY: Aim of our prospective non-randomized study was to evaluate the course of SH.MATERIAL AND METHODS: All patients with suspicion of SH referred to the Endocrinology Outpatient Clinic between 2014 and 2018 were recruited to prospective study.RESULTS: A total of 130 patients with SH were recruited for this study. T...
Source: Pediatric Endocrinology, Diabetes, and Metabolism - September 20, 2023 Category: Endocrinology Authors: Kamila Szeliga Aleksandra Antosz Karolina Skrzynska Barbara Kalina-Faska Aneta Gawlik Source Type: research
Lipid metabolism and renal function markers in obese adolescents
CONCLUSIONS: Renal function of the obese adolescents included in the study was normal and the associations with lipid metabolism were poorly expressed.PMID:37728460 | DOI:10.5114/pedm.2023.125612
Source: Pediatric Endocrinology, Diabetes, and Metabolism - September 20, 2023 Category: Endocrinology Authors: Aleksandra Radosz Anna Obuchowicz Source Type: research
Profile of plasma free amino acids, carnitine and acylcarnitines, and JAK2 < sup > v617f < /sup > mutation as potential metabolic markers in children with type 1 diabetic nephropathy
Biomed Chromatogr. 2023 Sep 20:e5747. doi: 10.1002/bmc.5747. Online ahead of print.ABSTRACTFifty diabetic nephropathy (DN) children with type 1 diabetes mellitus (T1DM) and 50 healthy matched controls were included. Chromatographic assays of 14 amino acids, free carnitine and 27 carnitine esters using high-performance liquid chromatography/electrospray ionization-mass spectroscopy, and genetic testing for JAK2v617f mutation using real-time PCR were performed. Patients had significantly lower levels of tyrosine, branched-chain amino acids (BCAAs), and BCAA/AAA (aromatic chain amino acids) ratios, glycine, arginine, ornithin...
Source: Biomedical Chromatography : BMC - September 20, 2023 Category: Biomedical Science Authors: Mohammed H Hassan Omyma Galal Hala M Sakhr Eman B Kamaleldeen Nadia Farouk Zekry Ekram Fateen Rana Toghan Source Type: research
The positive impact of lifestyle intervention on selected mio- and chemokines levels in prepubertal children with obesity
CONCLUSIONS: Personalized diet modification and regular, daily exercises may positively influence on the levels of irisin and chemerin.PMID:37728459 | DOI:10.5114/pedm.2023.127273
Source: Pediatric Endocrinology, Diabetes, and Metabolism - September 20, 2023 Category: Endocrinology Authors: Agnieszka Kozio ł-Kozakowska Ma łgorzata Wójcik Dominika Janu ś Jerzy Starzyk Source Type: research
Are menstrual disorders in adolescent girls related to metabolic disorders?
CONCLUSIONS: Adolescent girls with menstrual disorders are insulin resistant, regardless of PCOS diagnosis. The severity of menstrual disorders may be related to the incidence of lipid disorders in adolescent girls.PMID:37728458 | DOI:10.5114/pedm.2023.125364
Source: Pediatric Endocrinology, Diabetes, and Metabolism - September 20, 2023 Category: Endocrinology Authors: El żbieta Foryś Adrianna Baran Aleksandra Dziurdzia Ewelina Jarosz-W ójcik Pawe ł Matusik Aneta Gawlik Ryszard Tomaszewski Agnieszka Zachurzok Source Type: research
Assessment of fibroblast growth factor 21 in children with type 1 diabetes mellitus in relation to microvascular complications
CONCLUSIONS: FGF21 is significantly higher among children with DM1 than in controls. However, its role in diabetic microvascular complica-tions needs further assessment.PMID:37728457 | DOI:10.5114/pedm.2022.121372
Source: Pediatric Endocrinology, Diabetes, and Metabolism - September 20, 2023 Category: Endocrinology Authors: Nermien Tantawy Eman Sherif Randa M Matter Nouran Salah Nour Eldin Abozeid Heba Atif Source Type: research
Cerium oxide nanoparticles in diabetic foot ulcer management: Advances, limitations, and future directions
Colloids Surf B Biointerfaces. 2023 Sep 9;231:113535. doi: 10.1016/j.colsurfb.2023.113535. Online ahead of print.ABSTRACTDiabetic foot ulcer (DFU) is one of the most serious complications of diabetes, potentially resulting in wound infection and amputation under severe circumstances. Oxidative stress and dysbiosis are the primary factors that delay wound healing, posing challenges to effective treatment. Unfortunately, conventional approaches in these aspects have proven satisfactory in achieving curative outcomes. Recent research has increasingly focused on using nanoparticles, leveraging their potential in wound dressing...
Source: Colloids and Surfaces - September 20, 2023 Category: Biotechnology Authors: Haotian Xu Shiqi Li Xiaoxuan Ma Tingting Xue Fang Shen Yi Ru Jingsi Jiang Le Kuai Bin Li Hang Zhao Xin Ma Source Type: research
Potential bacteriophages to overcome bacterial infection of Alcaligenes faecalis in diabetic ulcer
CONCLUSIONS: The 6 isolates that were isolated had the ability to infect by forming a prophage that could inhibit the growth of Alcaligenes faecalis and other pathogenic bacteria in diabetic ulcers.PMID:37728456 | DOI:10.5114/pedm.2023.125363
Source: Pediatric Endocrinology, Diabetes, and Metabolism - September 20, 2023 Category: Endocrinology Authors: Erlia Narulita Vivi Indah Nur Cahyati Riska A Febrianti Mochammad Iqbal Source Type: research
The role of miR-433-3p in vascular calcification in type 2 diabetic patients: targeting WNT/ β-Catenin and RANKL/RANK/OPG signaling pathways
CONCLUSION: Collectively, the study documented that down-regulation of miR-433-3p may contribute to the development of VC through activating WNT/β-Catenin and RANKL/RANK/OPG signaling pathways.PMID:37728820 | DOI:10.1007/s11033-023-08792-9
Source: Molecular Biology Reports - September 20, 2023 Category: Molecular Biology Authors: Amira M Elshamy Yasser Mostafa Hafez Mohamed A E Safa Hoda A Ibrahim Mohamed Khalfallah Fatma H Rizk Eman F Eltabaa Muhammad T Abdel Ghafar Marwa Mohamed Atef Source Type: research
